{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:50:08Z","timestamp":1785873008177,"version":"3.56.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":519,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec id=\"S0195941700033464_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To describe the epidemiology of carbapenem-resistant Enterobacteriaceae (CRE) carriage and acquisition among hospitalized patients in an area of CRE endemicity.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033464_abs2\"><jats:title>Design.<\/jats:title><jats:p>Cohort study with a nested case-control study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033464_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Two acute care, academic hospitals in New York City.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033464_abs4\"><jats:title>Participants.<\/jats:title><jats:p>All patients admitted to 7 study units, including intensive care, medical-surgical, and acute rehabilitation units.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033464_abs5\"><jats:title>Method.<\/jats:title><jats:p>Perianal samples were collected from patients at admission and weekly thereafter to detect asymptomatic gastrointestinal carriage of CRE. A nested case-control study was performed to identify factors associated with CRE acquisition. Case patients were those who acquired CRE during a single hospitalization. Control subjects had no microbiologic evidence of CRE and at least 1 negative surveillance sample. Clinical data were abstracted from the medical record.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033464_abs6\"><jats:title>Results.<\/jats:title><jats:p>The prevalence of CRE in the study population was 5.4% (306 of 5,676 patients), and 104 patients met the case definition of acquisition during a single hospital stay. Mechanical ventilation (odds ratio [OR], 11.5), pulmonary disease (OR, 5.2), days of antibiotic therapy (OR, 1.04), and CRE colonization pressure (OR, 1.15) were independently associated with CRE acquisition. Pulsed-field gel electrophoresis analysis identified 87% of tested <jats:italic>Klebsiella pneumoniae<\/jats:italic> isolates as sharing related patterns (greater than 78% similarity), which suggests clonal transmission within and between the study hospitals.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033464_abs7\"><jats:title>Conclusions.<\/jats:title><jats:p>Critical illness and underlying medical conditions, CRE colonization pressure, and antimicrobial exposure are important risk factors for CRE acquisition. Adherence to infection control practices and antimicrobial stewardship appear to be critical components of a CRE control program.<\/jats:p><\/jats:sec>","DOI":"10.1086\/671270","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T21:57:48Z","timestamp":1370987868000},"page":"809-817","source":"Crossref","is-referenced-by-count":153,"title":["Prevalence and Risk Factors for Acquisition of Carbapenem-Resistant Enterobacteriaceae in the Setting of Endemicity"],"prefix":"10.1017","volume":"34","author":[{"given":"Mahesh","family":"Swaminathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saarika","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Poliansky","family":"Blash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopi","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Banach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"LaBombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen F.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Kitchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Calfee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700033464_ref016","doi-asserted-by":"publisher","DOI":"10.1086\/501721"},{"key":"S0195941700033464_ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03420.x"},{"key":"S0195941700033464_ref017","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.10.1127"},{"key":"S0195941700033464_ref003","doi-asserted-by":"publisher","DOI":"10.1086\/590661"},{"key":"S0195941700033464_ref012","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5639-5641.2005"},{"key":"S0195941700033464_ref004","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.12.1430"},{"key":"S0195941700033464_ref010","doi-asserted-by":"publisher","DOI":"10.1086\/648451"},{"key":"S0195941700033464_ref005","doi-asserted-by":"publisher","DOI":"10.1086\/652528"},{"key":"S0195941700033464_ref011","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks063"},{"key":"S0195941700033464_ref021","doi-asserted-by":"publisher","DOI":"10.1086\/656243"},{"key":"S0195941700033464_ref020","unstructured":"Siegel JD , Rhinehart E , Jackson M , Chiarello L ; Healthcare Infection Control Practices Advisory Committee. Management of multidrug-resistant organisms in healthcare settings, 2006. Centers for Disease Control and Prevention, 2006. http:\/\/www.cdc.gov\/ncidod\/dhqp\/pdf\/ar\/MDROGuideline2006.pdf. Accessed February 22, 2013."},{"key":"S0195941700033464_ref009","doi-asserted-by":"publisher","DOI":"10.1086\/666642"},{"key":"S0195941700033464_ref015","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00126-09"},{"key":"S0195941700033464_ref014","doi-asserted-by":"publisher","DOI":"10.1086\/511640"},{"key":"S0195941700033464_ref002","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01020-07"},{"key":"S0195941700033464_ref026","doi-asserted-by":"publisher","DOI":"10.1086\/651304"},{"key":"S0195941700033464_ref006","doi-asserted-by":"publisher","DOI":"10.1086\/661279"},{"key":"S0195941700033464_ref007","doi-asserted-by":"publisher","DOI":"10.1086\/667738"},{"key":"S0195941700033464_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.07.022"},{"key":"S0195941700033464_ref025","doi-asserted-by":"publisher","DOI":"10.1086\/669089"},{"key":"S0195941700033464_ref013","first-page":"2041","volume-title":"Clinical Microbiology Procedures Handbook","author":"Kitchel","year":"2010"},{"key":"S0195941700033464_ref018","doi-asserted-by":"publisher","DOI":"10.1086\/511793"},{"key":"S0195941700033464_ref008","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir025"},{"key":"S0195941700033464_ref019","volume-title":"Guidance for control of carbapenem-resistant Enterobacteriaceae (CRE)"},{"key":"S0195941700033464_ref023","first-page":"148","article-title":"Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing","volume":"4","author":"Snitkin","year":"2012","journal-title":"Sci Transi Med"},{"key":"S0195941700033464_ref024","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.8.972"},{"key":"S0195941700033464_ref001","doi-asserted-by":"publisher","DOI":"10.1086\/592412"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700033464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T20:36:10Z","timestamp":1556051770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700033464\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0195941700033464"],"URL":"https:\/\/doi.org\/10.1086\/671270","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}