{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:03:39Z","timestamp":1791237819210,"version":"4.1.0"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":488,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec id=\"S0195941700033750_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To identify predictors of community-onset extended-spectrum \u03b2-lactamase (ESBL)-producing <jats:italic>Escherichia coli<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033750_abs2\"><jats:title>Design.<\/jats:title><jats:p>Prospective case-control study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033750_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Acute care hospitals and ambulatory clinics in the Chicago, Illinois, region.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033750_abs4\"><jats:title>Patients.<\/jats:title><jats:p>Adults with <jats:italic>E. coli<\/jats:italic> clinical isolates cultured in ambulatory settings or within 48 hours of hospital admission.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033750_abs5\"><jats:title>Methods.<\/jats:title><jats:p>Cases were patients with ESBL-producing <jats:italic>E. coli<\/jats:italic> clinical isolates cultured in ambulatory settings or within 48 hours of admission, and controls were patients with non-ESBL-producing <jats:italic>E. coli<\/jats:italic> isolates, matched to cases by specimen, location, and date. Clinical variables were ascertained through interviews and medical record review. Molecular methods were used to identify ESBL types, sequence type ST131, and <jats:italic>aac(6\u2032)-Ib-cr<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033750_abs6\"><jats:title>Results.<\/jats:title><jats:p>We enrolled 94 cases and 158 controls. Multivariate risk factors for ESBL-producing <jats:italic>E. coli<\/jats:italic> infection included travel to India in the past year (odds ratio [OR], 14.40 [95% confidence interval (CI), 2.92-70.95]), ciprofloxacin use (OR, 3.92 [95% CI, 1.90-8.1]), and age (OR, 1.04 [95% CI, 1.02-1.06]). Case isolates exhibited high prevalence of CTX-M-15 (78%), ST131 (50%), and <jats:italic>aac(6\u2032)-Ib-cr<\/jats:italic> (66% of isolates with CTX-M-15).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700033750_abs7\"><jats:title>Conclusions.<\/jats:title><jats:p>Providers should be aware of the increased risk of ESBL-producing <jats:italic>E. coli<\/jats:italic> infection among returned travelers, especially those from India.<\/jats:p><\/jats:sec>","DOI":"10.1086\/671725","type":"journal-article","created":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T17:59:33Z","timestamp":1374083973000},"page":"947-953","source":"Crossref","is-referenced-by-count":56,"title":["Predictors and Molecular Epidemiology of Community-Onset Extended-Spectrum \u03b2-Lactamase\u2013Producing <i>Escherichia coli<\/i> Infection in a Midwestern Community"],"prefix":"10.1017","volume":"34","author":[{"given":"Ritu","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Strahilevitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payai P.","family":"Nagwekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Schora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilene","family":"Shevrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance 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