{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:44:48Z","timestamp":1782999888546,"version":"3.54.5"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":427,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec id=\"S0195941700034184_abs1\"><jats:title>Objective.<\/jats:title><jats:p>Describe the epidemiology of central line-associated bloodstream infections (CLABSIs) in neonatal intensive care units (NICUs) participating in a standardized and mandatory CLABSI surveillance program.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034184_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective cohort.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034184_abs3\"><jats:title>Setting.<\/jats:title><jats:p>We included patients admitted (April 2007-March 2011) to 7 level II\/III NICUs who developed a CLABSI (as defined by the National Healthcare Safety Network).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034184_abs4\"><jats:title>Methods<\/jats:title><jats:p>. CLABSIs\/1,000 central line\u2013days and device utilization ratio were calculated;<jats:italic>x<\/jats:italic><jats:sup>2<\/jats:sup>test, Student<jats:italic>t<\/jats:italic>test, Kruskal-Wallis, and Poisson regression were used.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034184_abs5\"><jats:title>Results.<\/jats:title><jats:p>Overall, 191 patients had 202 CLABSI episodes for a pooled mean rate of 4.0 CLABSIs\/1,000 central line-days and a device utilization ratio of 0.20. Annual pooled mean CLABSI rates increased from 3.6 in 2007-2008 to 5.1 CLABSIs\/1,000 central line-days in 2010-2011 (<jats:italic>P<\/jats:italic>= .01). The all-cause 30-day case fatality proportion was 8.9% (n = 17) and occurred a median of 8 days after CLABSI. Coagulase-negative<jats:italic>Staphylococcus<\/jats:italic>was identified in 112 (50.5%) cases.<jats:italic>Staphylococcus aureus<\/jats:italic>was identified in 22 cases, and 3 (13.6%) were resistant to methicillin. An underlying intra-abdominal pathology was found in 20% (40\/202) of CLABSI cases, 50% of which were reported in the last year of study. When adjusted for mean birth weight, annual CLABSI incidence rates were independently associated with the proportion of intra-abdominal pathology (<jats:italic>P<\/jats:italic>= .007) and the proportion of pulmonary pathology (<jats:italic>P<\/jats:italic>= .016) reported.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034184_abs6\"><jats:title>Conclusion.<\/jats:title><jats:p>The increase in CLABSI rates in Quebec NICUs seems to be associated with an increased proportion of cases with underlying intra-abdominal and pulmonary pathologies, which needs further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1086\/673464","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T01:07:12Z","timestamp":1379984832000},"page":"1167-1173","source":"Crossref","is-referenced-by-count":35,"title":["Central Line\u2013Associated Bloodstream Infection in Neonatal Intensive Care Units"],"prefix":"10.1017","volume":"34","author":[{"given":"Ana C.","family":"Blanchard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Rocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Frenette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Quach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700034184_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2004.10.001"},{"key":"S0195941700034184_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.05.006"},{"key":"S0195941700034184_ref002","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2873"},{"key":"S0195941700034184_ref022","doi-asserted-by":"publisher","DOI":"10.1086\/650448"},{"key":"S0195941700034184_ref001","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200001000-00012"},{"key":"S0195941700034184_ref033","doi-asserted-by":"publisher","DOI":"10.1086\/669074"},{"key":"S0195941700034184_ref005","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2002.1341"},{"key":"S0195941700034184_ref032","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000193300.25141.c5"},{"key":"S0195941700034184_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2007.01.006"},{"key":"S0195941700034184_ref004","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.18"},{"key":"S0195941700034184_ref012","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702009000300005"},{"key":"S0195941700034184_ref006","doi-asserted-by":"publisher","DOI":"10.1086\/655461"},{"key":"S0195941700034184_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2006.01.002"},{"key":"S0195941700034184_ref008","doi-asserted-by":"publisher","DOI":"10.1086\/651303"},{"key":"S0195941700034184_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2010.07.007"},{"key":"S0195941700034184_ref030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03174.x"},{"key":"S0195941700034184_ref011","doi-asserted-by":"publisher","DOI":"10.1086\/665323"},{"key":"S0195941700034184_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"S0195941700034184_ref014","doi-asserted-by":"publisher","DOI":"10.1086\/662588"},{"key":"S0195941700034184_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(97)90031-6"},{"key":"S0195941700034184_ref017","unstructured":"Centers for Disease Control and Prevention (CDC). 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