{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:07:28Z","timestamp":1755036448416},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":397,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec id=\"S0195941700034421_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To identify risk factors for pediatric<jats:italic>Candida<\/jats:italic>central line-associated bloodstream infections (CLABSIs).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034421_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective case-control study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034421_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Freestanding tertiary care children's hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034421_abs4\"><jats:title>Patients.<\/jats:title><jats:p>Patients with<jats:italic>Candida<\/jats:italic>CLABSI from January 31, 2000, through December 31, 2010, compared with age- and year-matched controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034421_abs5\"><jats:title>Methods.<\/jats:title><jats:p>Demographics, comorbidities, presence of indwelling foreign bodies, exposure to antibiotics or corticosteroids, total parenteral nutrition (TPN) or blood transfusions, complications, and outcome were evaluated. Bivariate and then logistic regression were used to compare temporal trends and risk factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034421_abs6\"><jats:title>Results.<\/jats:title><jats:p>A total of 160<jats:italic>Candida<\/jats:italic>CLABSI patients (median age, 1.96 years) were compared with 457 controls. Those with<jats:italic>Candida<\/jats:italic>CLABSIs were more likely to have intestinal failure (adjusted odds ratio [aOR], 6.777 [95% confidence interval (CI), 2.315\u201319.839];<jats:italic>P<\/jats:italic>&lt; .001), to have a gastrostomy tube in place (aOR, 4.156 [95% CI, 2.317\u20137.456];<jats:italic>P<\/jats:italic>&lt; .001), and to receive TPN (aOR, 3.897 [95% CI, 2.403\u20136.319];<jats:italic>P<\/jats:italic>&lt; .001) or blood transfusions (aOR, 2.990 [95% CI, 1.841\u20134.856];<jats:italic>P<\/jats:italic>&lt; .001), and they had a 3-fold increase in mortality (aOR, 3.543 [95% CI, 1.501\u20138.364];<jats:italic>P<\/jats:italic>= .004).<jats:italic>Candida albicans<\/jats:italic>was most common, but<jats:italic>non-albicans<\/jats:italic>strains resistant to amphotericin (<jats:italic>C. lusitaniae<\/jats:italic>) and fluconazole (<jats:italic>C. glabrata<\/jats:italic>and<jats:italic>C. krusei<\/jats:italic>) were also found.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700034421_abs7\"><jats:title>Conclusions.<\/jats:title><jats:p>Those patients with intestinal failure, gastrostomy tube presence, and\/or receipt of TPN and blood transfusions are at increased risk for development of<jats:italic>Candida<\/jats:italic>CLABSI.<\/jats:p><\/jats:sec>","DOI":"10.1086\/673988","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T20:27:52Z","timestamp":1382992072000},"page":"1266-1271","source":"Crossref","is-referenced-by-count":8,"title":["Incidence, Classification, and Risk Stratification for<i>Candida<\/i>Central Line\u2013Associated Bloodstream Infections in Pediatric Patients at a Tertiary Care Children's Hospital, 2000\u20132010"],"prefix":"10.1017","volume":"34","author":[{"given":"J. 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