{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:48:16Z","timestamp":1787161696276,"version":"build-2736575974"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"unspecified","delay-in-days":740,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec id=\"S0899823X00191706_abs1\">\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>To analyze trends in the incidence and pathogen distribution of healthcare-associated bloodstream infections (HABSIs) over a 20-year period (1992\u20132011).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00191706_abs2\">\n                    <jats:title>Design.<\/jats:title>\n                    <jats:p>Historical cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00191706_abs3\">\n                    <jats:title>Setting.<\/jats:title>\n                    <jats:p>Thirty-two-bed neonatal intensive care unit (NICU) in a tertiary referral hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00191706_abs4\">\n                    <jats:title>Patients.<\/jats:title>\n                    <jats:p>Neonates with HABSIs defined according to the criteria of the National Institute of Child Health and Development (NICHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00191706_abs5\">\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A hospital-based ongoing surveillance program was used to identify HABSI cases in neonates. A distinction between definite or possible HABSI was made according to the NICHD criteria. Incidence, incidence densities (HABSIs per 1,000 hospital-days and HABSIs per 1,000 total parenteral nutrition\u2013days), and case fatality rate were calculated. Logistic regression analysis was used to find time trends. Four periods of 5 years were considered when executing variance analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00191706_abs6\">\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      In total, 682 episodes of HABSIs occurred on 9,934 admissions (6.9%). The median total incidence density rate was 3.1 (interquartile range, 2.2\u20133.9). A significant increasing time trend in incidence density was observed for the period 1995\u20132011 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .003). A significant decrease in the case fatality rate was found in the last 5-year period (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). No neonate died following possible HABSIs, whereas the case fatality rate among neonates with definite HABSIs was 9.7%. Most HABSIs were caused by coagulase-negative staphylococci (\n                      <jats:italic>n<\/jats:italic>\n                      = 414 [60.7%]). A significant increase in\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      HABSI was observed in the last 10-year period (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00191706_abs7\">\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>\n                      An increase in incidence density rate occurred, while the case fatality rate dropped. Better perinatal care could be responsible for the latter. A decrease in days before infection and a high incidence of coagulase-negative\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      HABSIs indicate the need for vigorous application of evidence-based prevention initiatives, in particular for catheter care.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1086\/675836","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T17:06:47Z","timestamp":1395076007000},"page":"511-518","source":"Crossref","is-referenced-by-count":56,"title":["Healthcare-Associated Bloodstream Infections in a Neonatal Intensive Care Unit over a 20-Year Period (1992\u20132011): Trends in Incidence, Pathogens, and Mortality"],"prefix":"10.1017","volume":"35","author":[{"given":"Evelien","family":"Verstraete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerina","family":"Boelens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris De","family":"Coen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Claeys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Vogelaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Vanhaesebrouck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Blot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"S0899823X00191706_ref014","doi-asserted-by":"publisher","DOI":"10.1086\/650448"},{"key":"S0899823X00191706_ref010","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015665810739"},{"key":"S0899823X00191706_ref030","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211410"},{"key":"S0899823X00191706_ref024","first-page":"130","article-title":"Hospital acquired bloodstream infections in neonatal intensive care unit","volume":"46","author":"Bolat","year":"2011","journal-title":"Turk Arch Ped"},{"key":"S0899823X00191706_ref016","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.126458"},{"key":"S0899823X00191706_ref006","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2000.0852"},{"key":"S0899823X00191706_ref003","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"S0899823X00191706_ref023","doi-asserted-by":"publisher","DOI":"10.3201\/eid1111.050524"},{"key":"S0899823X00191706_ref032","doi-asserted-by":"publisher","DOI":"10.1086\/660361"},{"key":"S0899823X00191706_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/S1553-7250(10)36085-5"},{"key":"S0899823X00191706_ref012","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199011000-00009"},{"key":"S0899823X00191706_ref011","first-page":"293","volume":"27","author":"Stoll","year":"2003","journal-title":"studies from the NICHD Neonatal Research Network"},{"key":"S0899823X00191706_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"S0899823X00191706_ref007","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0552"},{"key":"S0899823X00191706_ref013","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1785"},{"key":"S0899823X00191706_ref019","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a02d8f"},{"key":"S0899823X00191706_ref018","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.119442"},{"key":"S0899823X00191706_ref022","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31819988bf"},{"key":"S0899823X00191706_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.12.020"},{"key":"S0899823X00191706_ref009","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.19.2357"},{"key":"S0899823X00191706_ref025","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200001000-00012"},{"key":"S0899823X00191706_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2007.08.019"},{"key":"S0899823X00191706_ref020","unstructured":"Lemaitre D . Vergelijkend onderzoek naar het effect op het aantal cathetergerelateerde septicemie\u00ebn bij kinderen met een zeer laag geboortegewicht door gebruik van transparante poly-uretha-neverbanden met verhoogde dampdoorlaatbaarheid [master's thesis]. Ghent University, 1995."},{"key":"S0899823X00191706_ref015","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2002.129427"},{"key":"S0899823X00191706_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2010.07.014"},{"key":"S0899823X00191706_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1489-7"},{"key":"S0899823X00191706_ref021","doi-asserted-by":"publisher","DOI":"10.1086\/657634"},{"key":"S0899823X00191706_ref008","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199807000-00004"},{"key":"S0899823X00191706_ref028","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182a72ee0"},{"key":"S0899823X00191706_ref027","doi-asserted-by":"publisher","DOI":"10.1086\/501755"},{"key":"S0899823X00191706_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2006.01.002"},{"key":"S0899823X00191706_ref026","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02079.x"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X00191706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T17:17:32Z","timestamp":1555953452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X00191706\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0899823X00191706"],"URL":"https:\/\/doi.org\/10.1086\/675836","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}