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A key immune regulator is vascular endothelial growth factor (VEGF), which is produced by Th2\u00a0inflammation and can itself contribute to Th2 pulmonary responses. In this study, we interrogated the role of VEGF signaling in a murine model of schistosomiasis\u2010induced PH with a phenotype of significant intrapulmonary Th2\u00a0inflammation, vascular remodeling, and elevated right ventricular pressures. We found that VEGF receptor blockade partially suppressed the levels of the Th2\u00a0inflammatory cytokines interleukin (IL)\u20104 and IL\u201013\u00a0in both the lung and the liver after <jats:italic>Schistosoma mansoni<\/jats:italic> exposure and suppressed pulmonary vascular remodeling. 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