{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:14:34Z","timestamp":1790900074152,"version":"4.1.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"unspecified","delay-in-days":679,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec id=\"S0899823X00192256_secab1\"><jats:title>Background<\/jats:title><jats:p>Treatment of<jats:italic>Staphylococcus aureus<\/jats:italic>colonization before surgery reduces risk of surgical site infection (SSI). The regimen of nasal mupirocin ointment and topical chlorhexidine gluconate is effective, but cost and patient compliance may be a barrier. Nasal povidone-iodine solution may provide an alternative to mupirocin.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00192256_secab2\"><jats:title>Methods<\/jats:title><jats:p>We conducted an investigator-initiated, open-label, randomized trial comparing SSI after arthroplasty or spine fusion in patients receiving topical chlorhexidine wipes in combination with either twice daily application of nasal mupirocin ointment during the 5 days before surgery or 2 applications of povidone-iodine solution into each nostril within 2 hours of surgical incision. The primary study end point was deep SSI within the 3 months after surgery.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00192256_secab3\"><jats:title>Results<\/jats:title><jats:p>In the modified intent-to-treat analysis, a deep SSI developed after 14 of 855 surgical procedures in the mupirocin group and 6 of 842 surgical procedures in the povidone-iodine group (<jats:italic>P<\/jats:italic>= .1);<jats:italic>S. aureus<\/jats:italic>deep SSI developed after 5 surgical procedures in the mupirocin group and 1 surgical procedure in the povidone-iodine group (<jats:italic>P<\/jats:italic>= .2). In the per protocol analysis,<jats:italic>S. aureus<\/jats:italic>deep SSI developed in 5 of 763 surgical procedures in the mupirocin group and 0 of 776 surgical procedures in the povidone-iodine group (<jats:italic>P<\/jats:italic>= .03).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00192256_secab4\"><jats:title>Conclusions<\/jats:title><jats:p>Nasal povidone-iodine may be considered as an alternative to mupirocin in a multifaceted approach to reduce SSI.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00192256_secab5\"><jats:title>Trial registration<\/jats:title><jats:p>ClinicalTrials.gov identifier:<jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:type=\"simple\" xlink:href=\"http:\/\/clinicaltrials.gov\/show\/NCT01313182\">NCT01313182<\/jats:uri>.<\/jats:p><\/jats:sec>","DOI":"10.1086\/676872","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T20:04:28Z","timestamp":1400702668000},"page":"826-832","source":"Crossref","is-referenced-by-count":140,"title":["Preventing Surgical Site Infections: A Randomized, Open-Label Trial of Nasal Mupirocin Ointment and Nasal Povidone-Iodine Solution"],"prefix":"10.1017","volume":"35","author":[{"given":"Michael","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shopsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germaine","family":"Cuff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith","family":"Skeete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alycia","family":"Foti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandy","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Inglima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Press","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Bosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"S0899823X00192256_ref229","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(97)90162-6"},{"key":"S0899823X00192256_ref232","doi-asserted-by":"publisher","DOI":"10.1086\/509837"},{"key":"S0899823X00192256_ref218","first-page":"312","article-title":"Surgical 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