{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:33:40Z","timestamp":1791203620860,"version":"4.2.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"unspecified","delay-in-days":587,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec id=\"S0899823X00193092_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To evaluate whether an ecologic inverse association exists between methicillin-susceptible <jats:italic>Staphylococcus aureus<\/jats:italic> (MSSA) prevalence and methicillin-resistant <jats:italic>S. aureus<\/jats:italic> (MRSA) prevalence in nursing homes.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193092_abs2\"><jats:title>Methods.<\/jats:title><jats:p>We conducted a secondary analysis of a prospective cross-sectional study of <jats:italic>S. aureus<\/jats:italic> prevalence in 26 nursing homes across Orange County, California, from 2008\u20132011. Admission prevalence was assessed using bilateral nares swabs collected from all new residents within 3 days of admission until 100 swabs were obtained. Point prevalence was assessed from a representative sample of 100 residents. Swab samples were plated on 5% sheep blood agar and Spectra MRSA chromogenic agar. If MRSA was detected, no further tests were performed. If MRSA was not detected, blood agar was evaluated for MSSA growth. We evaluated the association between MRSA and MSSA admission and point prevalence using correlation and linear regression testing.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193092_abs3\"><jats:title>Results.<\/jats:title><jats:p>We collected 3,806 total swabs. MRSA and MSSA admission prevalence were not correlated (<jats:italic>r<\/jats:italic> = \u22120.40, <jats:italic>P<\/jats:italic> = .09). However, MRSA and MSSA point prevalence were negatively correlated regardless of whether MSSA prevalence was measured among all residents sampled (<jats:italic>r<\/jats:italic> = \u22120.67, <jats:italic>P<\/jats:italic> = .0002) or among those who did not harbor MRSA (<jats:italic>r<\/jats:italic> = \u22120.41, <jats:italic>P<\/jats:italic> = .04). This effect persisted in regression models adjusted for the percentage of residents with diabetes (\u03b2 = \u22120.73, <jats:italic>P<\/jats:italic> = .04), skin lesions (\u03b2 = \u22121.17, <jats:italic>P<\/jats:italic> = .002), or invasive devices (\u03b2 = \u22121.4, <jats:italic>P<\/jats:italic> = .0006).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193092_abs4\"><jats:title>Conclusions.<\/jats:title><jats:p>The inverse association between MRSA and MSSA point prevalence and minimal association on admission prevalence suggest MSSA carriage may protect against MRSA acquisition in nursing homes. The minimal association on admission prevalence further suggests competition may occur during nursing home stays.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic> 2014;35(10):1257\u20131262<\/jats:p><\/jats:sec>","DOI":"10.1086\/678062","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T14:26:09Z","timestamp":1409754369000},"page":"1257-1262","source":"Crossref","is-referenced-by-count":3,"title":["Protective Effect of Methicillin-Susceptible <i>Staphylococcus aureus<\/i> Carriage against Methicillin-Resistant <i>S. aureus<\/i> Acquisition in Nursing Homes: A Prospective Cross-Sectional Study"],"prefix":"10.1017","volume":"35","author":[{"given":"Rupak","family":"Datta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellena M.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildy","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"S0899823X00193092_ref222","doi-asserted-by":"publisher","DOI":"10.1086\/367653"},{"key":"S0899823X00193092_ref220","doi-asserted-by":"publisher","DOI":"10.1086\/345476"},{"key":"S0899823X00193092_ref218","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.07.034"},{"key":"S0899823X00193092_ref212","doi-asserted-by":"publisher","DOI":"10.1086\/654001"},{"key":"S0899823X00193092_ref191","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.01.003"},{"key":"S0899823X00193092_ref224","unstructured":"Office of Statewide Health Planning and Development. http:\/\/www.oshpd.ca.gov\/HID\/DataFlow\/LTCMain.html. 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