{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:07:52Z","timestamp":1762866472909},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"unspecified","delay-in-days":587,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec id=\"S0899823X00193110_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To determine the durability of methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA)\u2013free status after patients are removed from contact precautions and the association of specific clearance policy variables with survival<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193110_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective cohort study from October 2007 to April 2013.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193110_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Veteran Affairs Boston Healthcare System.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193110_abs4\"><jats:title>Participants.<\/jats:title><jats:p>Patients with a prior history of MRSA who were removed from contact precautions after deemed cleared of their MRSA status by infection prevention.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193110_abs5\"><jats:title>Methods.<\/jats:title><jats:p>Active nasal screening results and clinical data from acute, long-term, and outpatient care facilities were evaluated to determine survival of MRSA-free status in a time-to-event analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193110_abs6\"><jats:title>Results.<\/jats:title><jats:p>A total of 351 unique patients were followed for 107,112 patient-days. The median age was 68 years. Overall, 249 (71%) of patients remained MRSA-free, and 102 (29%) reverted to MRSA positive. The median MRSA-free survival was 880 days. Comorbidities, presence of indwelling devices, and the use of systemic antibiotics at the time of clearance screening were not associated with MRSA-free survival. More than 21,000 days of inpatient isolation days were avoided during the study period.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193110_abs7\"><jats:title>Conclusions.<\/jats:title><jats:p>The majority of patients removed from contact precautions remained MRSA-free for more than 2 years. Antibiotic use at the time of clearance was not associated with reductions in MRSA-free survival. These findings can be used to simplify clearance criteria, promote clearance policies, and reduce patient isolation days.<\/jats:p><\/jats:sec>","DOI":"10.1086\/678065","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T21:40:18Z","timestamp":1409694018000},"page":"1271-1276","source":"Crossref","is-referenced-by-count":3,"title":["Survival Time of Methicillin-Resistant <i>Staphylococcus aureus<\/i>\u2013Free Status after Institutional Clearance"],"prefix":"10.1017","volume":"35","author":[{"given":"Paula A.","family":"Valencia-Rey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Strymish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Robillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalpana","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"S0899823X00193110_ref260","doi-asserted-by":"publisher","DOI":"10.1086\/649222"},{"key":"S0899823X00193110_ref259","doi-asserted-by":"publisher","DOI":"10.1086\/338234"},{"key":"S0899823X00193110_ref257","doi-asserted-by":"publisher","DOI":"10.1086\/652455"},{"key":"S0899823X00193110_ref255","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit206"},{"key":"S0899823X00193110_ref254","doi-asserted-by":"publisher","DOI":"10.1086\/668427"},{"key":"S0899823X00193110_ref253","doi-asserted-by":"publisher","DOI":"10.1086\/591061"},{"key":"S0899823X00193110_ref256","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04196-3"},{"key":"S0899823X00193110_ref252","doi-asserted-by":"publisher","DOI":"10.1086\/652530"},{"key":"S0899823X00193110_ref261","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03724.x"},{"key":"S0899823X00193110_ref258","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2008.05.019"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X00193110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T23:46:55Z","timestamp":1555890415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X00193110\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0899823X00193110"],"URL":"https:\/\/doi.org\/10.1086\/678065","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}