{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:45:00Z","timestamp":1770486300572,"version":"3.49.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"unspecified","delay-in-days":526,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec id=\"S0899823X00193572_abs1\"><jats:title>Objective.<\/jats:title><jats:p>Characterize the clinical and molecular epidemiology of new methicillin-resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(MRSA) acquisitions at nasal and extranasal sites among high-risk nursing home (NH) residents.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193572_abs2\"><jats:title>Design.<\/jats:title><jats:p>Multicenter prospective observational study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193572_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Six NHs in southeast Michigan.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193572_abs4\"><jats:title>Participants.<\/jats:title><jats:p>A total of 120 NH residents with an indwelling device (feeding tube and\/or urinary catheter).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193572_abs5\"><jats:title>Methods.<\/jats:title><jats:p>Active surveillance cultures from the nares, oropharynx, groin, perianal area, wounds (if present), and device insertion site(s) were collected upon enrollment, at day 14, and monthly thereafter. Pulsed-field gel electrophoresis and polymerase chain reaction for SCC<jats:italic>mec, agr<\/jats:italic>, and Panton-Valentine leukocidin were performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193572_abs6\"><jats:title>Results.<\/jats:title><jats:p>Of 120 participants observed for 16,290 device-days, 50 acquired MRSA (78% transiently, 22% persistently). New MRSA acquisitions were common in extranasal sites, particularly at device insertion, groin, and perianal areas (27%, 23%, and 17.6% of all acquisitions, respectively). Screening extranasal sites greatly increases the detection of MRSA colonization (100% of persistent carriers and 97.4% of transient carriers detected with nares, groin, perianal, and device site sampling vs 54.5% and 25.6%, respectively, for nares samples alone). Colonization at suprapubic urinary catheter sites generally persisted. Healthcare-associated MRSA (USA100 and USA100 variants) were the dominant strains (79.3% of all new acquisition isolates). Strain diversity was more common in transient carriers, including acquisition of USA500 and USA300 strains.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00193572_abs7\"><jats:title>Conclusion.<\/jats:title><jats:p>Indwelling device insertion sites as well as the groin and perianal area are important sites of new MRSA acquisitions in NH residents and play a role in the persistency of MRSA carriage. Clonal types differ among persistent and transient colonizers.<\/jats:p><\/jats:sec>","DOI":"10.1086\/678599","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T19:28:53Z","timestamp":1415215733000},"page":"1458-1465","source":"Crossref","is-referenced-by-count":26,"title":["Methicillin-Resistant<i>Staphylococcus aureus:<\/i>Site of Acquisition and Strain Variation in High-Risk Nursing Home Residents with Indwelling Devices"],"prefix":"10.1017","volume":"35","author":[{"given":"Kristen E.","family":"Gibson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara E.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cassone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary 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