{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:38:03Z","timestamp":1769125083912,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Vasoreactivity testing with inhaled NO is recommended for pulmonary arterial hypertension (PAH) because of its therapeutic and prognostic value. Sildenafil has acute pulmonary vasodilating properties, but its diagnostic and prognostic impact in PAH is unknown. Our objective was to compare acute vasodilating responses to sildenafil and those to NO during right heart catheterization and also their prognostic values in patients with PAH. Ninety\u2010nine patients with idiopathic PAH and 99 with associated PAH underwent vasoreactivity testing with NO and sildenafil. Only mild adverse effects of sildenafil, in the form of hypotension, were observed, at a rate of 4.5%. The acute responder rate was 8.1% for NO and 11.6% for sildenafil. The NO\u2010induced response in mean pulmonary arterial pressure and cardiac output correlated with the response to sildenafil. Thirteen patients were long\u2010term responders to calcium channel blockers (CCBs), and 3 of them were correctly identified by acute vasoreactivity test with both drugs. The specificity of the vasoreactivity test for identifying long\u2010term CCB responders was 88.9% for NO and 85.1% for sildenafil testing. A trend toward better survival was found in sildenafil and NO responders, compared with nonresponders. Use of sildenafil for vasoreactivity testing is safe. Sildenafil may be useful as alternative vasoreactivity\u2010testing agent, identifying the same number of long\u2010term CCB responders as NO. However, NO seems to be a more ideal testing drug because of its pharmacologic properties. Moreover, sildenafil vasoreactivity testing might contribute to an improved estimate of prognosis among patients with PAH.<\/jats:p>","DOI":"10.1086\/680355","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T17:00:43Z","timestamp":1427994043000},"page":"305-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Sildenafil versus Nitric Oxide for Acute Vasodilator Testing in Pulmonary Arterial Hypertension"],"prefix":"10.1002","volume":"5","author":[{"given":"Katrin","family":"Milger","sequence":"first","affiliation":[{"name":"University of Giessen and Marburg Lung Center Giessen, Germany, member of the German Center for Lung Research (DZL) Germany"},{"name":"Department of Internal Medicine V University of Munich Munich Germany"},{"name":"Comprehensive Pneumology Center Munich, Germany, member of the German Center for Lung Research (DZL) the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine F.","family":"Felix","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Voswinckel","sequence":"additional","affiliation":[{"name":"University of Giessen and Marburg Lung Center Giessen, Germany, member of the German Center for Lung Research (DZL) Germany"},{"name":"Department of Internal Medicine Health Center Wetterau Friedberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natascha","family":"Sommer","sequence":"additional","affiliation":[{"name":"University of Giessen and Marburg Lung Center Giessen, Germany, member of the German Center for Lung Research (DZL) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar H.","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of 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