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Our aim was to determine hospital mortality, length of hospitalization, and hospital charges pertaining to PH\u2010related hospitalizations and also the effects of codiagnoses and comorbidities. A retrospective review of the Kids\u2019 Inpatient Database during the years 2000, 2003, 2006, and 2009 was analyzed for patients \u226420 years of age with a diagnosis of PH by <jats:italic>ICD\u20109<\/jats:italic> (<jats:italic>International Classification of Diseases, Ninth Revision<\/jats:italic>) codes, along with associated diagnoses and comorbidities. Descriptive statistics, including Rao\u2010Scott \u03c7<jats:sup>2<\/jats:sup>, ANOVA, and logistic regression models, were utilized on weighted values with survey analysis procedures. The number of PH\u2010related hospital admissions is rising, from an estimated 7,331 (95% confidence interval [CI]: 5,556\u20139,106) in 2000 to 10,792 (95% CI: 8,568\u201313,016) in 2009. While infant age and congenital heart disease were most commonly associated with PH\u2010related hospitalizations, they were not associated with mortality. Overall mortality for PH\u2010related hospitalizations was greater than that for hospitalizations not associated with PH, 5.7% versus 0.4% (odds ratio: 16.22 [95% CI: 14.78%\u201317.8%], <jats:italic>P<\/jats:italic> &lt; 0.001), but mortality is decreasing over time. Sepsis, respiratory failure, acute renal failure, hepatic insufficiency, arrhythmias, and the use of extracorporeal membrane oxygenation are associated with mortality. The number of PH\u2010related hospitalizations is increasing in the United States. The demographics of PH in this study are evolving. Despite the increasing prevalence, mortality is improving.<\/jats:p>","DOI":"10.1086\/681226","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T18:45:03Z","timestamp":1429901103000},"page":"339-348","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Trends in Pediatric Pulmonary Hypertension\u2013Related Hospitalizations in the United States from 2000\u20132009"],"prefix":"10.1002","volume":"5","author":[{"given":"David B.","family":"Frank","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Children's Hospital of Philadelphia Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Crystal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics New York Presbyterian Morgan Stanley Children's Hospital\u2013Columbia University Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L. 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