{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T20:02:09Z","timestamp":1751400129139},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>In a subgroup of patients with systemic sclerosis (SSc), vasospasm affecting the pulmonary circulation may contribute to worsening respiratory symptoms, including dyspnea. Noninvasive assessment of pulmonary blood flow (PBF), utilizing inert\u2010gas rebreathing (IGR) and dual\u2010energy computed\u2010tomography pulmonary angiography (DE\u2010CTPA), may be useful for identifying pulmonary vasospasm. Thirty\u2010one participants (22 SSc patients and 9 healthy volunteers) underwent PBF assessment with IGR and DE\u2010CTPA at baseline and after provocation with a cold\u2010air inhalation challenge (CACh). Before the study investigations, participants were assigned to subgroups: group A included SSc patients who reported increased breathlessness after exposure to cold air (<jats:italic>n<\/jats:italic> = 11), group B included SSc patients without cold\u2010air sensitivity (<jats:italic>n<\/jats:italic> = 11), and group C patients included the healthy volunteers. Median change in PBF from baseline was compared between groups A, B, and C after CACh. Compared with groups B and C, in group A there was a significant decline in median PBF from baseline at 10\u00a0minutes (\u221210%; range: \u221252.2% to 4.0%; <jats:italic>P<\/jats:italic> &lt; 0.01), 20\u00a0minutes (\u221217.4%; \u221227.9% to 0.0%; <jats:italic>P<\/jats:italic> &lt; 0.01), and 30\u00a0minutes (\u22128.5%; \u221234.4% to 2.0%; <jats:italic>P<\/jats:italic> &lt; 0.01) after CACh. There was no significant difference in median PBF change between groups B or C at any time point and no change in pulmonary perfusion on DE\u2010CTPA. Reduction in pulmonary blood flow following CACh suggests that pulmonary vasospasm may be present in a subgroup of patients with SSc and may contribute to worsening dyspnea on exposure to cold.<\/jats:p>","DOI":"10.1086\/682221","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T18:38:05Z","timestamp":1436812685000},"page":"498-505","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Pulmonary Vasospasm in Systemic Sclerosis: Noninvasive Techniques for Detection"],"prefix":"10.1002","volume":"5","author":[{"given":"Gregory J.","family":"Keir","sequence":"first","affiliation":[{"name":"Royal Brompton Hospital London United Kingdom"},{"name":"Princess Alexandra Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Nair","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamatia","family":"Giannarou","sequence":"additional","affiliation":[{"name":"Imperial College London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Zhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Imperial College London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Oldershaw","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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