{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:54:54Z","timestamp":1789750494183,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007143","name":"Society for Marine Mammalogy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004837","name":"State of New Jersey Economic Development Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PPG\u20105P01HL108800\u201304"],"award-info":[{"award-number":["PPG\u20105P01HL108800\u201304"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Rapid access to lung\u2010derived cells from stable subjects is a major challenge in the pulmonary hypertension field, given the relative contraindication of lung biopsy. In these studies, we sought to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the potential to translate these findings to vascular beds in other nonlung tissues, in this instance perivascular skin mesenchymal cells (MCs). We utilized posttransplant or autopsy lung explant\u2013derived cells (ABCG2\u2010expressing mesenchymal progenitor cells [MPCs], fibroblasts) and skin\u2010derived MCs to test the hypothesis that perivascular ABCG2\u00a0MPCs derived from pulmonary arterial hypertension (PAH) patient lung and skin would express a gene profile reflective of ongoing vascular dysfunction. By analyzing the genetic signatures and pathways associated with abnormal ABCG2 lung MPC phenotypes during PAH and evaluating them in lung\u2010 and skin\u2010derived MCs, we have identified potential predictor genes for detection of PAH as well as a targetable mechanism to restore MPCs and microvascular function. These studies are the first to explore the utility of expanding the study of ABCG2\u00a0MPC regulation of the pulmonary microvasculature to the epidermis, in order to identify potential markers for adult lung vascular disease, such as PAH.<\/jats:p>","DOI":"10.1086\/688314","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T14:56:52Z","timestamp":1467298612000},"page":"483-497","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Shared Gene Expression Patterns in Mesenchymal Progenitors Derived from Lung and Epidermis in Pulmonary Arterial Hypertension: Identifying Key Pathways in Pulmonary Vascular Disease"],"prefix":"10.1002","volume":"6","author":[{"given":"Christa","family":"Gaskill","sequence":"first","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shennea","family":"Marriott","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidd","family":"Pratap","sequence":"additional","affiliation":[{"name":"Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapna","family":"Menon","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Research Institute Kochi"},{"name":"AnalyzeDat Consulting Services Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lora K.","family":"Hedges","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua P.","family":"Fessel","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Kropski","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeWayne","family":"Ames","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Loyd","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Hemnes","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis R.","family":"Roop","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gates Center for Regenerative Medicine and Stem Cell Biology University of Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight J.","family":"Klemm","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine; and Gates Center for Regenerative Medicine and Stem Cell Biology University of Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Majka","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Nashville Tennessee USA"},{"name":"Vanderbilt Center for Stem Cell Biology Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201312-443LD"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"issue":"3","key":"e_1_2_7_4_1","first-page":"8","article-title":"Severe pulmonary hypertension associated with COPD","volume":"5","author":"Stevens D","year":"2000","journal-title":"Ann Transplant"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1088"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13167-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200208-861OC"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303404"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000012754.72951.3D"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00057.2014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.961888"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/674770"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045-8932.109912"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.604"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00114.2014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000132476.87231.6F"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"194","article-title":"Familial primary pulmonary hypertension: Clinical patterns","volume":"129","author":"Loyd JE","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.037"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200602-165OC"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-02-0187"},{"issue":"4","key":"e_1_2_7_23_1","first-page":"772","article-title":"WNT1\u2010inducible signaling protein\u20101\u00a0mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis","volume":"119","author":"K\u00f6nigshoff M","year":"2009","journal-title":"J Clin Investig"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-320788"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38079"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20090978"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077108"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-11-10"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488598"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01889-07"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810364389"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.205"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/823875"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel378"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200111000-00008"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-009-0015-3"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001452"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0485TR"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells1040874"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014793"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025450"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207892"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090806"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.02.038"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210054"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203194"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.86"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16577"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2291OC"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800014200"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110431108"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.07.003"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3040"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds333"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.004"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2752-08.2008"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400331200"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9390-5"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42556"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.09.023"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02975"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00536.2007"},{"issue":"8","key":"e_1_2_7_63_1","first-page":"904","article-title":"Unrecognized glucose intolerance is common in pulmonary arterial hypertension","volume":"30","author":"Pugh ME","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163040"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/950658"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201103167"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-014-9515-2"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.406007"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt277"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200806049"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.09.013"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70233-4"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1086\/688314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1086\/688314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1086\/688314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:37:45Z","timestamp":1693204665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1086\/688314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1086\/688314"],"URL":"https:\/\/doi.org\/10.1086\/688314","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}