{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:58:26Z","timestamp":1775638706875,"version":"3.50.1"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":2253,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2008,11]]},"abstract":"\n Objective.<\/jats:title>\n To describe the frequency of selected antimicrobial resistance patterns among pathogens causing device-associated and procedure-associated healthcare-associated infections (HAIs) reported by hospitals in the National Healthcare Safety Network (NHSN).<\/jats:p>\n <\/jats:sec>\n \n Methods.<\/jats:title>\n Data are included on HAIs (ie, central line-associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, and surgical site infections) reported to the Patient Safety Component of the NHSN between January 2006 and October 2007. The results of antimicrobial susceptibility testing of up to 3 pathogenic isolates per HAI by a hospital were evaluated to define antimicrobial-resistance in the pathogenic isolates. The pooled mean proportions of pathogenic isolates interpreted as resistant to selected antimicrobial agents were calculated by type of HAI and overall. The incidence rates of specific device-associated infections were calculated for selected antimicrobial-resistant pathogens according to type of patient care area; the variability in the reported rates is described.<\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n \n Overall, 463 hospitals reported 1 or more HAIs: 412 (89%) were general acute care hospitals, and 309 (67%) had 200-1,000 beds. There were 28,502 HAIs reported among 25,384 patients. The 10 most common pathogens (accounting for 84% of any HAIs) were coagulase-negative staphylococci (15%),\n Staphylococcus aureus<\/jats:italic>\n (15%),\n Enterococcus<\/jats:italic>\n species (12%),\n Candida<\/jats:italic>\n species (11%),\n Escherichia coli<\/jats:italic>\n (10%),\n Pseudomonas aeruginosa<\/jats:italic>\n (8%),\n Klebsiella pneumoniae<\/jats:italic>\n (6%),\n Enterobacter<\/jats:italic>\n species (5%),\n Acinetobacter baumannii<\/jats:italic>\n (3%), and\n Klebsiella oxytoca<\/jats:italic>\n (2%). The pooled mean proportion of pathogenic isolates resistant to antimicrobial agents varied significantly across types of HAI for some pathogen-antimicrobial combinations. As many as 16% of all HAIs were associated with the following multidrug-resistant pathogens: methicillin-resistant\n S. aureus<\/jats:italic>\n (8% of HAIs), vancomycin-resistant\n Enterococcus faecium<\/jats:italic>\n (4%), carbapenem-resistant\n P. aeruginosa<\/jats:italic>\n (2%), extended-spectrum cephalosporin-resistant\n K. pneumoniae<\/jats:italic>\n (1%), extended-spectrum cephalosporin-resistant\n E. coli<\/jats:italic>\n (0.5%), and carbapenem-resistant\n A. baumannii, K. pneumoniae, K. oxytoca,<\/jats:italic>\n and\n E. coli<\/jats:italic>\n (0.5%). Nationwide, the majority of units reported no HAIs due to these antimicrobial-resistant pathogens.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1086\/591861","type":"journal-article","created":{"date-parts":[[2008,10,23]],"date-time":"2008-10-23T13:27:03Z","timestamp":1224768423000},"page":"996-1011","source":"Crossref","is-referenced-by-count":1672,"title":["Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006\u20132007"],"prefix":"10.1017","volume":"29","author":[{"given":"Alicia I.","family":"Hidron","sequence":"first","affiliation":[]},{"given":"Jonathan R.","family":"Edwards","sequence":"additional","affiliation":[]},{"given":"Jean","family":"Patel","sequence":"additional","affiliation":[]},{"given":"Teresa C.","family":"Horan","sequence":"additional","affiliation":[]},{"given":"Dawn M.","family":"Sievert","sequence":"additional","affiliation":[]},{"given":"Daniel A.","family":"Pollock","sequence":"additional","affiliation":[]},{"given":"Scott K.","family":"Fridkin","sequence":"additional","affiliation":[]},{"name":"National Healthcare Safety Network Team and Participating National Healthcare Safety Network Facilities","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S019594170002703X_ref003","doi-asserted-by":"publisher","DOI":"10.1086\/507636"},{"key":"S019594170002703X_ref013","unstructured":"CLSI. Analysis and presentation of cumulative antimicrobial susceptibility test data: approved guideline. 2nd ed. Wayne, PA: CLSI, 2006:M39-A2."},{"key":"S019594170002703X_ref023","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530080055041"},{"key":"S019594170002703X_ref009","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01284-07"},{"key":"S019594170002703X_ref017","doi-asserted-by":"publisher","DOI":"10.1086\/499367"},{"key":"S019594170002703X_ref008","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00756-06"},{"key":"S019594170002703X_ref007","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00576-07"},{"key":"S019594170002703X_ref016","unstructured":"CDC. National Nosocomial Infections Surveillance (NNIS) system report, data summary from October 1986-April 1998, issued June 1998. Available at: http:\/\/www.cdc.gov\/ncidod\/dhqp\/pdf\/nnis\/sar98net.PDE Accessed at December 12, 2007."},{"key":"S019594170002703X_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(99)00131-4"},{"key":"S019594170002703X_ref028","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2001.118408"},{"key":"S019594170002703X_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.12.022"},{"key":"S019594170002703X_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.04.001"},{"key":"S019594170002703X_ref014","doi-asserted-by":"publisher","DOI":"10.1086\/421495"},{"key":"S019594170002703X_ref022","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-001-8078-8"},{"key":"S019594170002703X_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2004.10.001"},{"key":"S019594170002703X_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70689-2"},{"key":"S019594170002703X_ref025","doi-asserted-by":"publisher","DOI":"10.3201\/eid0807.010427"},{"key":"S019594170002703X_ref005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe058023"},{"key":"S019594170002703X_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(99)70031-3"},{"key":"S019594170002703X_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.12.019"},{"key":"S019594170002703X_ref021","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-3-14"},{"key":"S019594170002703X_ref026","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1086\/598640","article-title":"Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997","volume":"29","author":"Diekema","year":"1999","journal-title":"Clin Infect Dis"},{"key":"S019594170002703X_ref011","unstructured":"CDC. The National Healthcare Safety Network (NHSN) Manual. Patient Safety Component Protocol. Division of Healthcare Quality Promotion. Available at: http:\/\/www.cdc.gov\/ncidod\/dhqp\/pdf\/nhsn\/NHSN_Manual_PatientSafetyProtocol_CURRENT.pdf. Accessed December 12, 2007."},{"key":"S019594170002703X_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.10.017"},{"key":"S019594170002703X_ref024","doi-asserted-by":"publisher","DOI":"10.1086\/520193"},{"key":"S019594170002703X_ref012","unstructured":"CLSI. Performance standards for antimicrobial susceptibility testing: 16th informational supplement. CLSI document. Wayne, PA: CLSI, 2008: M100-S18."},{"key":"S019594170002703X_ref020","unstructured":"Stephen JM , Jones RN . Assessment of pathogens and resistance (R) patterns among intensive care unit (ICU) patients in North America (NA): initial report from the SENTRY Antimicrobial Surveillance Program (2001). In: Programs and Abstracts of the 42nd Interscience Congress of Antimicrobial Agents and Chemotherapy American Society for Microbiology; September 27-30, 2002; San Diego, CA. Abstract C2-297."},{"key":"S019594170002703X_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm318"}],"container-title":["Infection Control & Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S019594170002703X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T18:03:00Z","timestamp":1556647380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S019594170002703X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S019594170002703X"],"URL":"https:\/\/doi.org\/10.1086\/591861","relation":{"is-referenced-by":[{"id-type":"doi","id":"10.1186\/s12866-025-04222-x","asserted-by":"object"}]},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}