{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:25:14Z","timestamp":1741238714987,"version":"3.38.0"},"reference-count":23,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":4,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Radiol. Prot."],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The radium dial painters (RDPs) are a well-described group of predominantly young women who incidentally ingested <jats:sup>226<\/jats:sup>Ra and <jats:sup>228<\/jats:sup>Ra as they painted luminescent watch dials in the first part of the twentieth century. In 1974 pathologist Dr William D. Sharpe published complete clinical and autopsy results for 42 former RDPs evaluated in the New Jersey Radium Research Project. This was an important paper due to the completeness of the observations. Surprisingly, in this study, clinicians noted a 35.5% incidence of hearing loss, both conductive and mixed etiologies. Since the 1974 publication, there has developed a considerable literature on radiation-induced hearing loss in patients undergoing radiotherapy for head and neck cancers. It is expected that hearing loss would also be associated with systemic inflammation. Recently, the neutrophil to lymphocyte ratio (NLR) has been shown in many cancer and non-cancer studies to be a nonspecific marker of inflammation. In prior collaborative efforts with the United States Transuranium and Uranium Registries and with the NCRP Million Person Study, it has been possible to evaluate NLR from medical records of a cohort of 166 former RDPs previously evaluated at Argonne National Laboratory. In addition, NLR was available in historic medical records of the sarcoma and nasopharyngeal cancer patients described in Rowland\u2019s summary of the Argonne studies. Using elevation of the NLR as a non-specific marker of inflammation, chronic inflammation has been observed in all cohorts with significant dose. The RDP cohort has had a unique exposure to radium, but the incidence of radiation-induced hearing loss here is uncertain. Due to cosmic radiation dose to astronauts in space flight, there is a significant interest in high LET radiation dose to the brain, including the auditory system. This paper should be considered as hypothesis generating\u2014that high LET radiation dose to the brain and auditory system may induce hearing loss.<\/jats:p>","DOI":"10.1088\/1361-6498\/adac69","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T22:48:01Z","timestamp":1737499681000},"page":"013502","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic inflammation in a radium dial painter cohort: elevated neutrophil to lymphocyte ratio and radiation-induced hearing loss"],"prefix":"10.1088","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9861-0266","authenticated-orcid":true,"given":"R E","family":"Goans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5629-8462","authenticated-orcid":false,"given":"L T","family":"Dauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-3760","authenticated-orcid":true,"given":"C J","family":"Iddins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-8710","authenticated-orcid":false,"given":"M","family":"Mumma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"McComish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-106X","authenticated-orcid":true,"given":"S Y","family":"Tolmachev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"jrpadac69bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/14017431.2014.932922","article-title":"Neutrophil\/lymphocyte ratio is related to the severity of idiopathic dilated cardiomyopathy","volume":"10","author":"Avci","year":"2014","journal-title":"Scand. Cardiovasc. J."},{"key":"jrpadac69bib2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ijrobp.2006.09.017","article-title":"Ototoxicity after radiotherapy for head and neck tumors","volume":"67","author":"Bhandare","year":"2007","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"jrpadac69bib3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/HP.0b013e3181b0306d","article-title":"Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications","volume":"98","author":"Blakely","year":"2010","journal-title":"Health Phys."},{"key":"jrpadac69bib4","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/rpd\/ncu127","article-title":"Further biodosimetry investigations using murine partial-body irradiation model","volume":"159","author":"Blakely","year":"2014","journal-title":"Radiat. Prot. Dosim."},{"key":"jrpadac69bib5","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.radmeas.2011.05.006","article-title":"Murine partial-body radiation exposure model for biodosimetry studies\u2014preliminary report","volume":"46","author":"Blakely","year":"2011","journal-title":"Radiat. Meas."},{"key":"jrpadac69bib6","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.3390\/ijms23073636","article-title":"Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases","volume":"23","author":"Buonacera","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"jrpadac69bib7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1097\/HP.0000000000000618","article-title":"The pseudo-Pelger Hu\u00ebt cell\u2014a new permanent radiation biomarker","volume":"112","author":"Goans","year":"2017","journal-title":"Health Phys."},{"key":"jrpadac69bib8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/HP.0000000000000831","article-title":"The pseudo Pelger-Hu\u00ebt cell as a retrospective dosimeter: analysis of a radium dial painter cohort","volume":"117","author":"Goans","year":"2019","journal-title":"Health Phys."},{"key":"jrpadac69bib9","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.critrevonc.2013.03.010","article-title":"The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer","volume":"88","author":"Guthrie","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"jrpadac69bib10","doi-asserted-by":"publisher","first-page":"4765","DOI":"10.1096\/fj.12-215228","article-title":"Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects","volume":"26","author":"Hayashi","year":"2012","journal-title":"FASEB J."},{"key":"jrpadac69bib11","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bjc.2014.317","article-title":"The prognostic impact of the neutrophil to lymphocyte ratio in patients with small-cell lung cancer","volume":"111","author":"Kang","year":"2014","journal-title":"Br. J. Cancer"},{"key":"jrpadac69bib12","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6498\/ac7e02","article-title":"Methods of improving brain dose estimates for internally deposited radionuclides","volume":"42","author":"Leggett","year":"2022a","journal-title":"J. Radiol. Prot."},{"key":"jrpadac69bib13","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1080\/09553002.2018.1554923","article-title":"Potential improvements in brain dose estimates for internal emitters","volume":"98","author":"Leggett","year":"2022b","journal-title":"Int. J. Radiat. Biol."},{"key":"jrpadac69bib14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09553002.2021.1917785","article-title":"Radium dial workers: back to the future","volume":"26","author":"Martinez","year":"2021","journal-title":"Int. J. Radiat. Biol."},{"key":"jrpadac69bib15","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1002\/hed.23201","article-title":"Characteristics of radiation-induced sensorineural hearing loss in head and neck cancer: a systematic review","volume":"35","author":"Mujica-Mota","year":"2013","journal-title":"Head Neck"},{"author":"National Insitute on Deafness and other Communication Disorders, NIDCD","key":"jrpadac69bib16"},{"key":"jrpadac69bib17","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1080\/09553000903154799","article-title":"Multiple blood-proteins approach for early-response assessment using a in vivo murine radiation model","volume":"85","author":"Ossetrova","year":"2009","journal-title":"Int. J. Radiat. Biol."},{"key":"jrpadac69bib18","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/HP.0b013e3181abaabf","article-title":"Combined approach of hematological biomarkers and plasma protein SAA for improvement of radiation dose assessment in triage biodosimetry applications","volume":"98","author":"Ossetrova","year":"2010","journal-title":"Health Phys."},{"year":"1994","author":"Rowland","key":"jrpadac69bib19"},{"key":"jrpadac69bib20","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1080\/14992027.2017.1353710","article-title":"Chemoradiation-induced hearing loss remains a major concern for head and neck cancer patients","volume":"57","author":"Schmitt","year":"2018","journal-title":"Int. J. Audiol."},{"key":"jrpadac69bib21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0013-9351(74)90043-7","article-title":"Chronic radium intoxication: clinical and autopsy findings in long-term New Jersey survivors","volume":"8","author":"Sharpe","year":"1974","journal-title":"Environ. Res."},{"key":"jrpadac69bib22","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2014rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec","year":"2001","journal-title":"Bratislavske lekarske listy"},{"key":"jrpadac69bib23","first-page":"p 17","article-title":"Changes of ratio of peripheral neutrophils and lymphocytes after radiation exposure may serve as a prognostic indicator of accident severity","author":"Zhang","year":"2004"}],"container-title":["Journal of Radiological Protection"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T16:33:15Z","timestamp":1741192395000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6498\/adac69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3,5]]},"published-print":{"date-parts":[[2025,3,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6498\/adac69","relation":{},"ISSN":["0952-4746","1361-6498"],"issn-type":[{"type":"print","value":"0952-4746"},{"type":"electronic","value":"1361-6498"}],"subject":[],"published":{"date-parts":[[2025,3,1]]},"assertion":[{"value":"Chronic inflammation in a radium dial painter cohort: elevated neutrophil to lymphocyte ratio and radiation-induced hearing loss","name":"article_title","label":"Article Title"},{"value":"Journal of Radiological Protection","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2025 Society for Radiological Protection. Published on behalf of SRP by IOP Publishing Limited. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-08-21","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-01-21","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-03-05","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}