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This will enable pre-hospital care, better patient compliance, and minimize its clinically significant side effect of electrolyte imbalance. The present paper highlights the practical feasibility and challenges of establishing an oral route for delivering Ca-DTPA and Zn-DTPA with the research around it. Also, the paper highlights the importance of establishing an oral dose and the dosing schedule for Ca-DTPA and Zn-DTPA before plunging into its formulation development. These advancements underline the potential of orally administered chelating agents and alternative delivery methods in addressing the limitations of current intravenous formulations and improving accessibility and patient outcomes.<\/jats:p>","DOI":"10.1088\/1361-6498\/adc013","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T22:49:01Z","timestamp":1741906141000},"page":"011002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Optimizing Ca-DTPA\/Zn-DTPA therapy for internal decorporation: transitioning from intravenous to oral route with insights on safety and toxicity"],"prefix":"10.1088","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6997-8758","authenticated-orcid":true,"given":"Nidhi","family":"Sandal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Mahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"jrpadc013bib1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1177\/0960327118781929","article-title":"Decorporation potential of lansoprazole against radiothallium (201 Tl) in internally contaminated BALB\/c mice and New Zealand White rabbits","volume":"38","author":"Nishad","year":"2019","journal-title":"Hum. 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