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With the rapid development of nanotechnology, a new way to overcome antibiotic resistance has opened up. Based on the many and diverse properties of MoS\n                    <jats:sub>2<\/jats:sub>\n                    nanosheets that have attracted wide attention, in particular their antibacterial potential, herein, a novel antimicrobial agent to combat resistant gram-positive\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and gram-negative\n                    <jats:italic>Salmonella<\/jats:italic>\n                    was prepared using chitosan functionalized MoS\n                    <jats:sub>2<\/jats:sub>\n                    nanosheets loading tetracycline hydrochloride drugs (abbreviated to CM-TH). The antibacterial and anti-biofilm activities of the CM-TH nanocomposites showed the synergetic effect that the combination of nanomaterials and antibiotics was more efficient than either working alone. In particularly, the minimum inhibitory concentration values generally decreased by a factor of dozens, suggesting that CM-TH may become a possible alternative to traditional antibiotics in disrupting biofilms and overcoming antibiotic resistance in treating medical diseases.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/aa6c9b","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T11:19:18Z","timestamp":1491909558000},"page":"225101","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":37,"title":["Antibiotic-loaded MoS\n                    <sub>2<\/sub>\n                    nanosheets to combat bacterial resistance via biofilm inhibition"],"prefix":"10.1088","volume":"28","author":[{"given":"Xu","family":"Zhang","sequence":"first","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunjie","family":"Huang","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baowei","family":"Yang","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daohong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Wang","sequence":"additional","affiliation":[{"name":"Northwest A&F University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"nanoaa6c9bbib1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-3-319-40746-3_2","type":"book","article-title":"Development of resistance to antibiotics","author":"Bhattacharjee","year":"2016"},{"key":"nanoaa6c9bbib2","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1097\/QCO.0b013e328358afe5","type":"journal-article","article-title":"\u2018Old\u2019 antibiotics for emerging multidrug-resistant bacteria","volume":"25","author":"Bergen","year":"2012","journal-title":"Current Opinion in Infectious Diseases"},{"key":"nanoaa6c9bbib3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1517\/13543784.2014.848853","type":"journal-article","article-title":"Combating multidrug-resistant Gram-negative bacterial infections","volume":"23","author":"Xu","year":"2014","journal-title":"Expert Opinion on Investigational Drugs"},{"key":"nanoaa6c9bbib4","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1016\/j.addr.2005.04.005","type":"journal-article","article-title":"Clinical impact and relevance of antibiotic resistance","volume":"57","author":"French","year":"2005","journal-title":"Adv. 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