{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:15:11Z","timestamp":1783170911971,"version":"3.54.6"},"reference-count":56,"publisher":"IOP Publishing","issue":"24","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["ZA 191\/33-1"],"award-info":[{"award-number":["ZA 191\/33-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2017,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Novel tin oxide field-effect-transistors (SnO\n                    <jats:sub>2<\/jats:sub>\n                    NW-FET) for pH and protein detection applicable in the healthcare sector are reported. With a SnO\n                    <jats:sub>2<\/jats:sub>\n                    NW-FET the proof-of-concept of a bio-sensing device is demonstrated using the carrier transport control of the FET channel by a (bio-) liquid modulated gate. Ultra-thin Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    fabricated by a low temperature atomic layer deposition (ALD) process represents a sensitive layer to H\n                    <jats:sup>+<\/jats:sup>\n                    ions safeguarding the nanowire at the same time. Successful pH sensitivity is demonstrated for pH ranging from 3 to 10. For protein detection, the SnO\n                    <jats:sub>2<\/jats:sub>\n                    NW-FET is functionalized with a receptor molecule which specifically interacts with the protein of interest to be detected. The feasibility of this approach is demonstrated via the detection of a biotinylated protein using a NW-FET functionalized with streptavidin. An immediate label-free electronic read-out of the signal is shown. The well-established Enzyme-Linked Immunosorbent Assay (ELISA) method is used to determine the optimal experimental procedure which would enable molecular binding events to occur while being compatible with a final label-free electronic read-out on a NW-FET. Integration of the bottom-up fabricated SnO\n                    <jats:sub>2<\/jats:sub>\n                    NW-FET pH- and biosensor into a microfluidic system (lab-on-a-chip) allows the automated analysis of small volumes in the 400\n                    <jats:italic>\u03bc<\/jats:italic>\n                    l range as would be desired in portable on-site point-of-care (POC) devices for medical diagnosis.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/aa7015","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T07:15:16Z","timestamp":1493363716000},"page":"245503","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Label-free SnO\n                    <sub>2<\/sub>\n                    nanowire FET biosensor for protein detection"],"prefix":"10.1088","volume":"28","author":[{"given":"Markus H","family":"Jakob","sequence":"first","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Dong","sequence":"additional","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Gutsch","sequence":"additional","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Chatelle","sequence":"additional","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abinaya","family":"Krishnaraja","sequence":"additional","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Weber","sequence":"additional","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Zacharias","sequence":"additional","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"nanoaa7015bib1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.nantod.2011.02.001","type":"journal-article","volume":"6","author":"Chen","year":"2011","journal-title":"Nano Today"},{"key":"nanoaa7015bib2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.bios.2014.03.057","type":"journal-article","volume":"60","author":"Shen","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"nanoaa7015bib3","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1109\/TED.2008.2005168","type":"journal-article","volume":"55","author":"Stern","year":"2008","journal-title":"IEEE Trans. Electron Devices"},{"key":"nanoaa7015bib4","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1016\/j.bios.2008.12.035","type":"journal-article","volume":"24","author":"Zhang","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"nanoaa7015bib5","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.snb.2010.02.021","type":"journal-article","volume":"146","author":"Zhang","year":"2010","journal-title":"Sensors Actuators B"},{"key":"nanoaa7015bib6","doi-asserted-by":"publisher","first-page":"114017","DOI":"10.1073\/pnas.0406159101","type":"journal-article","volume":"101","author":"Patolsky","year":"2004","journal-title":"PNAS"},{"key":"nanoaa7015bib7","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.1073\/pnas.0406368102","type":"journal-article","volume":"102","author":"Wang","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"nanoaa7015bib8","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1109\/TNANO.2008.2006165","type":"journal-article","volume":"7","author":"Curreli","year":"2008","journal-title":"IEEE Trans. Nanotechnology"},{"key":"nanoaa7015bib9","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1109\/ECTC.2007.374071","type":"other","author":"Liu","year":"2007"},{"key":"nanoaa7015bib10","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.snb.2010.04.049","type":"journal-article","volume":"148","author":"Choi","year":"2010","journal-title":"Sensors Actuators B"},{"key":"nanoaa7015bib11","doi-asserted-by":"publisher","first-page":"6645","DOI":"10.3390\/s110706645","type":"journal-article","volume":"11","author":"Hagen","year":"2011","journal-title":"Sensors (Basel, Switzerland)"},{"key":"nanoaa7015bib12","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1109\/ECTC.2008.4550146","type":"other","author":"Liu","year":"2008"},{"key":"nanoaa7015bib13","doi-asserted-by":"publisher","DOI":"10.1109\/ESSDERC.2012.6343352","type":"conference-proceedings","article-title":"Top-down fabricated ZnO nanowire transistors for application in biosensors","author":"Sultan","year":"2012"},{"key":"nanoaa7015bib14","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/9\/095508","type":"journal-article","volume":"19","author":"Choi","year":"2008","journal-title":"Nanotechnology"},{"key":"nanoaa7015bib15","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/adma.200304889","type":"journal-article","volume":"15","author":"Kolmakov","year":"2003","journal-title":"Adv. Mater."},{"key":"nanoaa7015bib16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nnano.2008.400","type":"journal-article","volume":"4","author":"Bj\u00f6rk","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"nanoaa7015bib17","doi-asserted-by":"publisher","first-page":"6070","DOI":"10.1021\/ja070788m","type":"journal-article","volume":"129","author":"Kuang","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"nanoaa7015bib18","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1515\/amm-2015-0089","type":"journal-article","volume":"60","author":"Yu","year":"2015","journal-title":"Arch. Metall. Mater."},{"key":"nanoaa7015bib19","doi-asserted-by":"publisher","author":"Rani","year":"2004","DOI":"10.1109\/TENCON.2004.1415019","type":"other"},{"key":"nanoaa7015bib20","doi-asserted-by":"publisher","author":"Go","year":"2010","DOI":"10.1109\/IEDM.2010.5703325","type":"other"},{"key":"nanoaa7015bib21","first-page":"567","type":"journal-article","volume":"25","author":"Bedner","year":"2013","journal-title":"Sensors Mater."},{"key":"nanoaa7015bib22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0265-928X(86)85010-6","type":"journal-article","volume":"2","author":"Bergveld","year":"1986","journal-title":"Biosensors"},{"key":"nanoaa7015bib23","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1109\/T-ED.1983.21284","type":"journal-article","volume":"30","author":"Bousse","year":"1983","journal-title":"IEEE Trans. Electron Devices"},{"key":"nanoaa7015bib24","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1109\/NANO.2010.5697862","type":"other","author":"Wang","year":"2010"},{"key":"nanoaa7015bib25","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nnano.2012.82","type":"journal-article","volume":"7","author":"Duan","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"nanoaa7015bib26","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1021\/nn100936h","type":"journal-article","volume":"4","author":"Khamaisi","year":"2010","journal-title":"ACS Nano"},{"key":"nanoaa7015bib27","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.bios.2013.02.009","type":"journal-article","volume":"45","author":"Li","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"nanoaa7015bib28","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1109\/TED.2012.2200105","type":"journal-article","volume":"59","author":"Ahn","year":"2012","journal-title":"IEEE Trans. Electron Devices"},{"key":"nanoaa7015bib29","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1126\/science.1208455","type":"journal-article","volume":"333","author":"Tsivion","year":"2011","journal-title":"Science (New York, NY)"},{"key":"nanoaa7015bib30","doi-asserted-by":"publisher","first-page":"6433","DOI":"10.1021\/nn3020695","type":"journal-article","volume":"6","author":"Tsivion","year":"2012","journal-title":"ACS Nano"},{"key":"nanoaa7015bib31","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.3390\/s100301679","type":"journal-article","volume":"10","author":"Shinwari","year":"2010","journal-title":"Sensors (Basel, Switzerland)"},{"key":"nanoaa7015bib32","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1021\/nl034139u","type":"journal-article","volume":"3","author":"Besteman","year":"2003","journal-title":"Nano Lett."},{"key":"nanoaa7015bib33","doi-asserted-by":"publisher","DOI":"10.1063\/1.2775090","type":"journal-article","volume":"91","author":"Minot","year":"2007","journal-title":"Appl. Phys. Lett."},{"key":"nanoaa7015bib34","article-title":"Large scale functional nanostructures and nanodevices","author":"Menzel","year":"2013","type":"other"},{"key":"nanoaa7015bib35","doi-asserted-by":"publisher","first-page":"4342","DOI":"10.1002\/adfm.201101549","type":"journal-article","volume":"21","author":"Menzel","year":"2011","journal-title":"Adv. Funct. Mater."},{"key":"nanoaa7015bib36","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.bios.2015.12.086","type":"journal-article","volume":"79","author":"Tarasov","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"nanoaa7015bib37","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1021\/nl0712217","type":"journal-article","volume":"7","author":"Dattoli","year":"2007","journal-title":"Nano Lett."},{"key":"nanoaa7015bib38","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1021\/jp0271054","type":"journal-article","volume":"107","author":"Arnold","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"nanoaa7015bib39","doi-asserted-by":"publisher","first-page":"5479","DOI":"10.1039\/c3nr06690h","type":"journal-article","volume":"6","author":"Van","year":"2014","journal-title":"Nanoscale"},{"key":"nanoaa7015bib40","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0925-4005(92)80077-B","type":"journal-article","volume":"6","author":"Meixner","year":"1992","journal-title":"Sensors Actuators B"},{"key":"nanoaa7015bib41","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/21\/42\/425505","type":"journal-article","volume":"21","author":"Lu","year":"2010","journal-title":"Nanotechnology"},{"key":"nanoaa7015bib42","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0925-4005(99)00443-8","type":"journal-article","volume":"66","author":"Ito","year":"2000","journal-title":"Sensors Actuators B"},{"key":"nanoaa7015bib43","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0925-4005(98)00040-9","type":"journal-article","volume":"49","author":"Jamasb","year":"1998","journal-title":"Sensors Actuators B"},{"key":"nanoaa7015bib44","doi-asserted-by":"publisher","first-page":"420","DOI":"10.2741\/1538","type":"journal-article","volume":"10","author":"Xu","year":"2005","journal-title":"Frontiers Biosci"},{"key":"nanoaa7015bib45","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1117\/12.213163","type":"journal-article","volume":"2634","author":"Pijanowska","year":"1995","journal-title":"Optoelectron. Electron. Sensors"},{"key":"nanoaa7015bib46","doi-asserted-by":"publisher","first-page":"9291","DOI":"10.1021\/nn303795r","type":"journal-article","volume":"6","author":"Tarasov","year":"2012","journal-title":"ACS Nano"},{"key":"nanoaa7015bib47","doi-asserted-by":"publisher","first-page":"3400","DOI":"10.1109\/TED.2007.909059","type":"journal-article","volume":"54","author":"Nair","year":"2007","journal-title":"IEEE Trans. Electron Devices"},{"key":"nanoaa7015bib48","doi-asserted-by":"publisher","first-page":"15584","DOI":"10.1021\/ja066506k","type":"journal-article","volume":"128","author":"Choi","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"nanoaa7015bib49","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.jcis.2003.12.022","type":"journal-article","volume":"271","author":"Peng","year":"2004","journal-title":"J. Colloid Interface Sci."},{"key":"nanoaa7015bib50","doi-asserted-by":"publisher","first-page":"152e","DOI":"10.1093\/nar\/gng152","type":"journal-article","volume":"31","author":"Mortlock","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"nanoaa7015bib51","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1021\/nl203666a","type":"journal-article","volume":"12","author":"Kulkarni","year":"2012","journal-title":"Nano Lett."},{"key":"nanoaa7015bib52","first-page":"1","type":"journal-article","volume":"49","author":"Kim","year":"2006","journal-title":"J. Korean Phys. Soc."},{"key":"nanoaa7015bib53","doi-asserted-by":"publisher","first-page":"5245","DOI":"10.1021\/nl302434w","type":"journal-article","volume":"12","author":"Elnathan","year":"2012","journal-title":"Nano Lett."},{"key":"nanoaa7015bib54","doi-asserted-by":"publisher","first-page":"6266","DOI":"10.1021\/ac901157x","type":"journal-article","volume":"81","author":"Chua","year":"2009","journal-title":"Anal. Chem."},{"key":"nanoaa7015bib55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2012.08.035","type":"journal-article","volume":"749","author":"Zhang","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"nanoaa7015bib56","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature05498","type":"journal-article","volume":"445","author":"Stern","year":"2007","journal-title":"Nature"}],"container-title":["Nanotechnology"],"original-title":[],"link":[{"URL":"http:\/\/stacks.iop.org\/0957-4484\/28\/i=24\/a=245503?key=crossref.e049229fba51e93924b58ddbb5fde234","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"http:\/\/stacks.iop.org\/0957-4484\/28\/i=24\/a=245503\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0957-4484\/28\/i=24\/a=245503\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0957-4484\/28\/i=24\/a=245503?key=crossref.e049229fba51e93924b58ddbb5fde234","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:16:34Z","timestamp":1783167394000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aa7015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,25]]},"references-count":56,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2017,5,25]]},"published-print":{"date-parts":[[2017,6,16]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6528\/aa7015","relation":{},"ISSN":["0957-4484","1361-6528"],"issn-type":[{"value":"0957-4484","type":"print"},{"value":"1361-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,25]]},"assertion":[{"value":"Label-free SnO\n                      2\n                      nanowire FET biosensor for protein detection","name":"article_title","label":"Article Title"},{"value":"Nanotechnology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2017 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-02-07","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-04-28","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-05-25","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}