{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:09:10Z","timestamp":1793394550149,"version":"4.5.0"},"reference-count":48,"publisher":"IOP Publishing","issue":"43","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"UNAM-PAPIIT","award":["IN220416"],"award-info":[{"award-number":["IN220416"]}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["330328"],"award-info":[{"award-number":["330328"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EU FP7 EU-Mexico Collaborative project BisNano","award":["NMP4-EU-Mexico-2013-263878"],"award-info":[{"award-number":["NMP4-EU-Mexico-2013-263878"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2017,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In recent years, nanomaterials have been used in the medical-dental field as new alternative antimicrobial agents. Bismuth subsalicylate (BSS) has been used as an antimicrobial agent, but the effect of BSS in the form of nanoparticles (BSS-nano) as a potential antimicrobial agent has not been tested, in specific against bacteria responsible for periodontal disease. The aim of this study was to evaluate the antibacterial effect of BSS-nano against oral anaerobic bacteria and to assess the safety of BSS-nano by evaluating their cytotoxicity in human gingival fibroblast (HGF-1) cells. BSS-nano were synthesized by laser ablation and were previously physico-chemically characterized using\n                    <jats:italic>in vitro<\/jats:italic>\n                    assays. The antibacterial activity was measured using the tetrazolium-based XTT assay, and cytotoxicity was determined using lactate dehydrogenase (LDH) and MTS assays in HGF-1 cells. Transmission electron microscopy of HGF-1 exposed to BSS-nano was also performed. BSS-nano was shown to have a primary size of 4\u201322 nm and a polygonal shape. Among the tested bacterial strains, those with a greater sensitivity to BSS-nano (highest concentration of 21.7\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) were\n                    <jats:italic>A. actinomycetemcomitans, C. gingivalis,<\/jats:italic>\n                    and\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    . BSS-nano at a concentration of 60\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    showed low cytotoxicity (6%) in HFG-1 cells and was mainly localized intracellularly in acidic vesicles. Our results indicate that the concentration of BSS-nano used as an effective antibacterial agent does not induce cytotoxicity in mammalian cells; thus, BSS-nano can be applied as an antibacterial agent in dental materials or antiseptic solutions.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/aa8838","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T08:45:11Z","timestamp":1503564311000},"page":"435101","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Bismuth subsalicylate nanoparticles with anaerobic antibacterial activity for dental applications"],"prefix":"10.1088","volume":"28","author":[{"given":"A L","family":"Vega-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Almaguer-Flores","sequence":"additional","affiliation":[{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Flores-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaciones Nucleares, Departamento de F\u00edsica, Carretera M\u00e9xico-Toluca s\/n, La Marquesa Ocoyoacac,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Camps","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaciones Nucleares, Departamento de F\u00edsica, Carretera M\u00e9xico-Toluca s\/n, La Marquesa Ocoyoacac,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Uribe-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Toxicologia, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, CDMX,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O G","family":"Aztatzi-Aguilar","sequence":"additional","affiliation":[{"name":"Departamento de Toxicologia, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, CDMX,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"De Vizcaya-Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Toxicologia, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, CDMX,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"nanoaa8838bib1","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.cden.2010.03.002","type":"journal-article","article-title":"Microbiology of dental plaque biofilms and their role in oral health and caries","volume":"54","author":"Marsh","year":"2010","journal-title":"Dental Clinics North Am."},{"key":"nanoaa8838bib2","first-page":"373","type":"book","article-title":"Oral infections","author":"Allaker","year":"1998","edition":"9th edn"},{"key":"nanoaa8838bib3","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1128\/AAC.44.2.456-457.2000","type":"journal-article","article-title":"Resistance to mercury and antimicrobial agents in Streptococcus mutans isolates from human subjects in relation to exposure to dental amalgam fillings","volume":"44","author":"Leistevuo","year":"2000","journal-title":"Antimicrobial Agents Chemother."},{"key":"nanoaa8838bib4","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1111\/j.1365-2672.2012.05253.x","type":"journal-article","article-title":"Silver nanoparticles: the powerful nanoweapon against multidrug-resistant bacteria","volume":"112","author":"Rai","year":"2012","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-06-20","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-08-24","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-09-26","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}