{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:42:38Z","timestamp":1791837758837,"version":"4.3.4"},"reference-count":56,"publisher":"IOP Publishing","issue":"46","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2018,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nanoparticles (NPs) enter the environment mainly through waste water effluents, accidental spillage, and industrial runoffs. This is worrying because NPs can enter the human body owing to their large aspect-to-size ratio and reactive surfaces that facilitate their penetration through biological barriers and thus can induce oxidative stress in host cells. Therefore, there is a growing concern about the toxicity of NPs, which needs to be addressed. Thus, this study investigated the ameliorative effects of\n                    <jats:italic>Moringa<\/jats:italic>\n                    <jats:italic>oleifera<\/jats:italic>\n                    seed extract (MOSE) in\n                    <jats:italic>Cyprinus<\/jats:italic>\n                    <jats:italic>carpio<\/jats:italic>\n                    exposed to copper nanoparticles (Cu-NPs). For the\n                    <jats:italic>in vivo<\/jats:italic>\n                    assessment of the shielding effects of MOSE, 240 samples of\n                    <jats:italic>C. carpio<\/jats:italic>\n                    (40\u201345 g) were randomly allocated to 24 experimental tanks (10 fish\/tank of 40 L) 24 h prior to the start of this experiment. The experimental fish were faced with the water-born exposure of a pre-determined dose of 1.5 mg Cu-NPs\/l along with pre- and post-treatment with different doses (100 or 200 or 300 mg l\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) of MOSE for 28 days. The MOSE showed significant ameliorative effect on the antioxidant defense, in response to the elevated levels of Cu-NP-induced oxidative stress. It also played a protective role as indicated by the suppression of the histological alterations in the gills and liver of fish exposed to the Cu-NPs. It was concluded that the Cu-NP-induced toxicity in\n                    <jats:italic>C. carpio<\/jats:italic>\n                    was ameliorated by the use of MOSE in this study. Moreover, the post-Cu-NP treatment stage showed more protective effects of MOSE than the pre-Cu-NP treatment phase. Further studies are suggested to determine the optimum dose and delivery method of MOSE for similar or different NP exposed fish.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/aade23","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T16:27:46Z","timestamp":1537547266000},"page":"464003","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Retracted: Ameliorative effects of\n                    <i>Moringa oleifera<\/i>\n                    on copper nanoparticle induced toxicity in\n                    <i>Cyprinus carpio<\/i>\n                    assessed by histology and oxidative stress markers"],"prefix":"10.1088","volume":"29","author":[{"given":"Aasma","family":"Noureen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhat","family":"Jabeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-056X","authenticated-orcid":false,"given":"Tanveer A","family":"Tabish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Kashif","family":"Zahoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehana","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajid","family":"Yaqub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Shakoor","family":"Chaudhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"nanoaade23bib1","first-page":"1209","type":"journal-article","volume":"6","author":"Yousefian","year":"2012","journal-title":"Adv. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-06-27","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-08-31","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-09-21","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}