{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:16:43Z","timestamp":1783977403739,"version":"3.55.0"},"reference-count":41,"publisher":"IOP Publishing","issue":"8","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81673214"],"award-info":[{"award-number":["81673214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2019,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To increase the efficacy of small molecule chemotherapeutic drug (SMCD) and reduce its toxic and side effects, we selected two model drugs doxorubicin (DOX) and chloroquine (CQ). DOX is a SMCD and CQis a chemosensitizer with autophagy inhibition. Poly(lactic-co-glycolic acid) (PLGA) and alpha-tocopherol polyethylene glycol 1000 succinate were chosen as delivery carriers to design and prepare a novel type of drug co-delivery single-nanoparticles by emulsification-solvent volatilisation, named NP\n                    <jats:sub>DOX+CQ<\/jats:sub>\n                    . The physicochemical properties of NP\n                    <jats:sub>DOX+CQ<\/jats:sub>\n                    were characterised. Then A549 cells and A549\/Taxol cells were used for the\n                    <jats:italic>in vitro<\/jats:italic>\n                    anti-cancer effect study. At the same time, cellular uptake, intracellular migration and anti-cancer mechanism of nanoparticles were studied. The NPs showed a uniform spherical shape with good dispersibility, and both drugs had good encapsulation efficiency and loading capacity. In all formulations, NP\n                    <jats:sub>DOX+CQ<\/jats:sub>\n                    showed the highest\n                    <jats:italic>in vitro<\/jats:italic>\n                    cytotoxicity. The results showed that NPs could protect drugs from being recognised and excluded by P-glycoprotein (P-gp). Moreover, the results of the mechanistic study demonstrated that NPs were transported by autophagy process after being taken up by the cells. Therefore, during the migration of NP\n                    <jats:sub>DOX+CQ<\/jats:sub>\n                    , CQ could exert its efficacy and block autophagy so that DOX would not be hit by autophagy. Western Blot results showed that NP\n                    <jats:sub>DOX+CQ<\/jats:sub>\n                    had the best inhibition effect of autophagy. It can be concluded that the system can prevent the drug from being recognised and excluded by P-gp, and CQ blocks the process of autophagy so that the DOX is protected and more distributed to the nucleus of multidrug resistance (MDR) cell. The NP\n                    <jats:sub>DOX+CQ<\/jats:sub>\n                    constructed in this study provides a feasible strategy for reversing MDR in tumour cells.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/aaf51b","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T17:15:34Z","timestamp":1543598134000},"page":"085101","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Co-delivery nanoparticles of doxorubicin and chloroquine for improving the anti-cancer effect\n                    <i>in vitro<\/i>"],"prefix":"10.1088","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-6127","authenticated-orcid":false,"given":"Jia-Hui","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-7802","authenticated-orcid":false,"given":"Chong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-He","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2300-0076","authenticated-orcid":false,"given":"Ling-Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Jie","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6078-8459","authenticated-orcid":false,"given":"Hao-Han","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-8490","authenticated-orcid":false,"given":"Su-Yun","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-4651","authenticated-orcid":false,"given":"Shu-Qin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"nanoaaf51bbib1","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1158\/1078-0432.CCR-06-9000","type":"journal-article","article-title":"A concise history of the cancer and leukemia group B","volume":"12","author":"Schilsky","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"nanoaaf51bbib2","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1080\/10717544.2017.1410256","type":"journal-article","article-title":"Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy","volume":"24","author":"Qi","year":"2017","journal-title":"Drug Deliv."},{"key":"nanoaaf51bbib3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0378-5173(01)00950-4","type":"journal-article","article-title":"Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly (lactide-co-glycolide) microsphere formulations for potential combination therapy in cancer","volume":"234","author":"Hussain","year":"2002","journal-title":"Int. J. Pharm."},{"key":"nanoaaf51bbib4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.4155\/tde.10.13","type":"journal-article","article-title":"Nanoparticle-assisted combination therapies for effective cancer treatment","volume":"1","author":"Hu","year":"2010","journal-title":"Ther. Deliv."},{"key":"nanoaaf51bbib5","doi-asserted-by":"publisher","first-page":"4996","DOI":"10.1021\/nn5010815","type":"journal-article","article-title":"Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation","volume":"8","author":"Guo","year":"2014","journal-title":"ACS Nano"},{"key":"nanoaaf51bbib6","doi-asserted-by":"publisher","first-page":"6118","DOI":"10.1016\/j.biomaterials.2014.04.034","type":"journal-article","article-title":"Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer","volume":"35","author":"Lv","year":"2014","journal-title":"Biomaterials"},{"key":"nanoaaf51bbib7","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1021\/acs.molpharmaceut.5b00536","type":"journal-article","article-title":"Co-delivery of pirarubicin and paclitaxel by human serum albumin nanoparticles to enhance antitumor effect and reduce systemic toxicity in breast cancers","volume":"12","author":"Yi","year":"2015","journal-title":"Mol. Pharm."},{"key":"nanoaaf51bbib8","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.biomaterials.2008.10.062","type":"journal-article","article-title":"The co-delivery of paclitaxel and herceptin using cationic micellar nanoparticles","volume":"30","author":"Lee","year":"2009","journal-title":"Biomaterials"},{"key":"nanoaaf51bbib9","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jconrel.2011.08.125","type":"journal-article","article-title":"The synergistic effect of herceptin and docetaxel in polylactide-D-\u03b1-tocopheryl polyethylene glycol succinate (PLA-TPGS) nanoparticles","volume":"152","author":"Liu","year":"2011","journal-title":"J. Control. Release"},{"key":"nanoaaf51bbib10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jconrel.2013.01.035","type":"journal-article","article-title":"Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin E TPGS-cisplatin prodrug nanoparticles for multimodality treatment of cancer","volume":"169","author":"Mi","year":"2013","journal-title":"J. Control. Release"},{"key":"nanoaaf51bbib11","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1021\/bm401550r","type":"journal-article","article-title":"Toroidal-spiral particles for codelivery of anti-VEGFR-2antibody and irinotecan: a potential implant to hinder recurrenceof glioblastoma multiforme","volume":"15","author":"Sharma","year":"2014","journal-title":"Biomacromole"},{"key":"nanoaaf51bbib12","doi-asserted-by":"publisher","first-page":"25468","DOI":"10.1038\/srep25468","type":"journal-article","article-title":"Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"nanoaaf51bbib13","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.msec.2016.03.083","type":"journal-article","article-title":"A dual-targeting drug co-delivery system for tumor chemo- and gene combined therapy","volume":"64","author":"Zhang","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"nanoaaf51bbib14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jconrel.2012.08.032","type":"journal-article","article-title":"Monodisperse double-walled microspheres loaded with chitosan-p53 nanoparticles and doxorubicin for combined gene therapy and chemotherapy","volume":"163","author":"Xu","year":"2012","journal-title":"J. Control. Release"},{"key":"nanoaaf51bbib15","doi-asserted-by":"publisher","first-page":"5149","DOI":"10.1016\/j.biomaterials.2013.03.044","type":"journal-article","article-title":"Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for treatment of human hepatocellular carcinoma","volume":"34","author":"Xu","year":"2013","journal-title":"Biomaterials"},{"key":"nanoaaf51bbib16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jconrel.2015.08.006","type":"journal-article","article-title":"Hyperbranched-hyperbranched polymeric nanoassembly to mediate controllable co-delivery of siRNA and drug for synergistic tumor therapy","volume":"216","author":"Jia","year":"2015","journal-title":"J. Control. Release"},{"key":"nanoaaf51bbib17","doi-asserted-by":"publisher","first-page":"4357","DOI":"10.2147\/IJN.S46900","type":"journal-article","article-title":"Nanopharmaceuticals (part 1): products on the market","volume":"9","author":"Weissig","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"nanoaaf51bbib18","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ejps.2016.10.011","type":"journal-article","article-title":"\u2018Gold nanoparticles composite-folic acid conjugated graphene oxide nanohybrids\u2019 for targeted chemo-thermal cancer ablation: in vitro screening and in vivo studies","volume":"96","author":"Chauhan","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"nanoaaf51bbib19","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jconrel.2015.11.016","type":"journal-article","article-title":"The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and x-ray imaging","volume":"220","author":"Hao","year":"2015","journal-title":"J. Control. Release"},{"key":"nanoaaf51bbib20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.actbio.2015.07.024","type":"journal-article","article-title":"pH-responsive metallo-supramolecular nanogel for synergistic chemo-photodynamic therapy","volume":"25","author":"Yao","year":"2015","journal-title":"Acta Biomater."},{"key":"nanoaaf51bbib21","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.biomaterials.2016.11.057","type":"journal-article","article-title":"Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic\/chemo therapy","volume":"117","author":"Chen","year":"2016","journal-title":"Biomaterials"},{"key":"nanoaaf51bbib22","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.2147\/IJN.S128790","type":"journal-article","article-title":"Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance","volume":"12","author":"Zhang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"nanoaaf51bbib23","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/978-0-387-46401-5_1","type":"book","volume":"vol 595","author":"Aggarwal","year":"2007"},{"key":"nanoaaf51bbib24","doi-asserted-by":"publisher","first-page":"77986","DOI":"10.1039\/C5RA15313A","type":"journal-article","article-title":"Co-delivery of doxorubicin hydrochloride and verapamil hydrochloride by pH-sensitive polymersomes for the reversal of multidrug resistance","volume":"5","author":"Li","year":"2015","journal-title":"RSC Adv."},{"key":"nanoaaf51bbib25","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ijpharm.2011.05.082","type":"journal-article","article-title":"Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes","volume":"416","author":"Patel","year":"2011","journal-title":"Int. J. Pharm."},{"key":"nanoaaf51bbib26","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3109\/10717544.2012.724473","type":"journal-article","article-title":"Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance","volume":"19","author":"Sarisozen","year":"2012","journal-title":"Drug Deliv."},{"key":"nanoaaf51bbib27","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.biopha.2016.12.138","type":"journal-article","article-title":"Co-delivery of docetaxel and curcumin prodrug via dual-targeted nanoparticles with synergistic antitumor activity against prostate cancer","volume":"88","author":"Yan","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"nanoaaf51bbib28","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1016\/j.biomaterials.2013.10.034","type":"journal-article","article-title":"The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"nanoaaf51bbib29","doi-asserted-by":"publisher","first-page":"9144","DOI":"10.1016\/j.biomaterials.2014.07.028","type":"journal-article","article-title":"The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"nanoaaf51bbib30","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.ijpharm.2015.10.009","type":"journal-article","article-title":"Co-delivery of docetaxel and chloroquine via PEO\u2013PPO\u2013PCL\/TPGS micelles for overcoming multidrug resistance","volume":"495","author":"Shi","year":"2015","journal-title":"Int. J. Pharm."},{"key":"nanoaaf51bbib31","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.7150\/thno.9933","type":"journal-article","article-title":"Enhancing therapeutic effects of docetaxel-loaded dendritic copolymer nanoparticles by co-treatment with autophagy inhibitor on breast cancer","volume":"4","author":"Zhang","year":"2014","journal-title":"Theranostics"},{"key":"nanoaaf51bbib32","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1002\/mabi.201000117","type":"journal-article","article-title":"N-Boc-histidine-capped PLGA-PEG-PLGA as a smart polymer for drug delivery sensitive to tumor extracellular pH","volume":"10","author":"Chang","year":"2010","journal-title":"Macromol. Biosci."},{"key":"nanoaaf51bbib33","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.1021\/jf202135j","type":"journal-article","article-title":"PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms","volume":"59","author":"Xie","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"nanoaaf51bbib34","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0168-3659(00)00364-3","type":"journal-article","article-title":"Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers","volume":"71","author":"Feng","year":"2001","journal-title":"J. Control. Release"},{"key":"nanoaaf51bbib35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0168-3659(02)00025-1","type":"journal-article","article-title":"Vitamin E TPGS used as emulsifier in the solvent evaporation\/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol\u00ae)","volume":"80","author":"Mu","year":"2002","journal-title":"J. Control. Release"},{"key":"nanoaaf51bbib36","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.actbio.2015.11.031","type":"journal-article","article-title":"Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer","volume":"30","author":"Zhu","year":"2016","journal-title":"Acta Biomater."},{"key":"nanoaaf51bbib37","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.biomaterials.2005.05.104","type":"journal-article","article-title":"Nanoparticles of poly(lactide)\/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release","volume":"27","author":"Zhang","year":"2006","journal-title":"Biomaterials"},{"key":"nanoaaf51bbib38","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/ppsc.201400048","type":"journal-article","article-title":"Docetaxel\u2010loaded nanoparticles of dendritic amphiphilic block copolymer H40\u2010PLA\u2010b\u2010TPGS for cancer treatment","volume":"32","author":"Zeng","year":"2015","journal-title":"Part. Part. Syst. Charact."},{"key":"nanoaaf51bbib39","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.colsurfb.2016.05.088","type":"journal-article","article-title":"CS\/PAA@TPGS\/PLGA nanoparticles with intracellular pH-sensitive sequential release for delivering drug to the nucleus of MDR cells","volume":"145","author":"Wang","year":"2016","journal-title":"Colloids Surf. B"},{"key":"nanoaaf51bbib40","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1021\/am508340m","type":"journal-article","article-title":"TPGS2k\/PLGA nanoparticles for overcoming multidrug resistance by interfering mitochondria of human alveolar adenocarcinoma cells","volume":"7","author":"Wang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"nanoaaf51bbib41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2015.10.019","type":"journal-article","article-title":"\u2018Combo\u2019 nanomedicine: co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy","volume":"98","author":"Kemp","year":"2015","journal-title":"Adv. Drug. Deliv. Rev."}],"container-title":["Nanotechnology"],"original-title":[],"link":[{"URL":"http:\/\/stacks.iop.org\/0957-4484\/30\/i=8\/a=085101?key=crossref.33e21cf89a681840235078a458f1b312","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"http:\/\/stacks.iop.org\/0957-4484\/30\/i=8\/a=085101\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0957-4484\/30\/i=8\/a=085101\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0957-4484\/30\/i=8\/a=085101?key=crossref.33e21cf89a681840235078a458f1b312","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T14:01:30Z","timestamp":1772287290000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/aaf51b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,28]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,12,28]]},"published-print":{"date-parts":[[2019,2,22]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6528\/aaf51b","relation":{},"ISSN":["0957-4484","1361-6528"],"issn-type":[{"value":"0957-4484","type":"print"},{"value":"1361-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,28]]},"assertion":[{"value":"Co-delivery nanoparticles of doxorubicin and chloroquine for improving the anti-cancer effect\n                      in vitro","name":"article_title","label":"Article Title"},{"value":"Nanotechnology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2018 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-06-08","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-11-30","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-12-28","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}