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Recent identification of AD biomarkers has led to the diagnosis of AD before the onset of dementia. It has been shown that\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    is a valuable model for studying human neurodegeneration, including AD. According to its properties, curcumin shows promising potential for the diagnosis of AD. In order to improve its use, new formulations, including nanotechnology-based delivery systems, have been applied. The current study aims to diagnose AD by detecting the accumulation of amyloid beta-peptide via carbon-dot\u2013curcumin nanoparticle conjugation in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . The accumulation of amyloid beta-peptide has been detected via the conjugate using the fluorescence imaging technique. These results suggest that carbon-dot\u2013curcumin nanoparticle conjugation could be used as a diagnostic tool for AD.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/ab7535","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T18:00:32Z","timestamp":1581444032000},"page":"365102","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of nano-conjugate on\n                    <i>Drosophila<\/i>\n                    for early diagnosis of Alzheimer\u2019s disease"],"prefix":"10.1088","volume":"31","author":[{"given":"Aya","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas H","family":"Ghallab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdi","family":"Shehata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel-Rahman N","family":"Zekri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-0907","authenticated-orcid":false,"given":"Ola S","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"nanoab7535bib1","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1037\/a0029857","type":"journal-article","volume":"27","author":"Wilson","year":"2012","journal-title":"Psychol. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2019-10-17","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-02-11","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-06-24","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}