{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:00:47Z","timestamp":1791810047518,"version":"4.3.4"},"reference-count":47,"publisher":"IOP Publishing","issue":"32","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2020,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Magnesium-doped copper spinel ferrite superparamagnetic nanoparticles (Mg\n                    <jats:sub>(1-x)<\/jats:sub>\n                    Cu\n                    <jats:sub>x<\/jats:sub>\n                    Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPMNPs, 0.2 \u2264 x \u2264 0.8) were successfully synthesized by a hydrothermal method. The cytotoxicity effects and cell viability of MCF-7 on human breast cancer cells pre and post exposure to the Mg\n                    <jats:sub>1-x<\/jats:sub>\n                    Cu\n                    <jats:sub>x<\/jats:sub>\n                    Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPMNPs at different concentrations of 0.1, 1, 10 and 100\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    under radiotherapy were studied by MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay. Here, x-ray diffraction, scanning electron microscopy, atomic force microscopy, UV-visible spectrophotometry, Fourier transform infrared spectroscopy and vibrating-sample magnetometry were evaluated for the crystal structure, morphology, optical and magnetic property of the Mg\n                    <jats:sub>(1-x)<\/jats:sub>\n                    Cu\n                    <jats:sub>x<\/jats:sub>\n                    Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPMNPs. The results showed that the Mg\n                    <jats:sub>(1-x)<\/jats:sub>\n                    Cu\n                    <jats:sub>x<\/jats:sub>\n                    Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPMNPs all at\n                    <jats:italic>x<\/jats:italic>\n                    values had no significant cytotoxicity at concentrations of 0.1,1 and 10\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    , but were enhanced by increasing of Cu content. Furthermore, cell destruction of MCF-7 human breast cancer cells post exposure to Mg\n                    <jats:sub>(1-x)<\/jats:sub>\n                    Cu\n                    <jats:sub>x<\/jats:sub>\n                    Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPMNPs under x-ray irradiation was enhanced by increasing the Cu content and concentration. Superparamagnetic properties of the Mg\n                    <jats:sub>(1-x)<\/jats:sub>\n                    Cu\n                    <jats:sub>x<\/jats:sub>\n                    Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPMNPs cause their localization and elimination, by only an external magnetic field. In conclusion, the Mg\n                    <jats:sub>(1-x)<\/jats:sub>\n                    Cu\n                    <jats:sub>x<\/jats:sub>\n                    Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPMNPs with optimum values of\n                    <jats:italic>x<\/jats:italic>\n                    = 0.2 (10\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and\n                    <jats:italic>x<\/jats:italic>\n                    = 0.6 (1\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) can be considered as a nano-radiosensitizer because of the synergistic treatment effect without cytotoxicity on the MCF-7 cells.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/ab8cf2","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T18:30:43Z","timestamp":1587753043000},"page":"325706","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Mg\n                    <sub>(1-x)<\/sub>\n                    Cu\n                    <sub>x<\/sub>\n                    Fe\n                    <sub>2<\/sub>\n                    O\n                    <sub>4<\/sub>\n                    superparamagnetic nanoparticles as nano-radiosensitizer agents in radiotherapy of MCF-7 human breast cancer cells"],"prefix":"10.1088","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-4256","authenticated-orcid":false,"given":"Alireza","family":"Meidanchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"nanoab8cf2bib1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","type":"journal-article","volume":"69","author":"Siegel","year":"2019","journal-title":"A Cancer J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-01-23","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-04-24","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-05-28","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}