{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:08:49Z","timestamp":1792516129761,"version":"4.5.0"},"reference-count":56,"publisher":"IOP Publishing","issue":"6","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2021,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The current study reports advanced, ecofriendly and biosynthesized silver NPs for diverse biomedical and environmental applications using\n                    <jats:italic>Flammulina velutipes<\/jats:italic>\n                    as biosource. In the study, a simple aqueous extract of\n                    <jats:italic>F. velutipes<\/jats:italic>\n                    was utilized to reduce the AgNO\n                    <jats:sub>3<\/jats:sub>\n                    into stable elemental silver (Ag\n                    <jats:sup>0<\/jats:sup>\n                    ) at a nanometric scale. The NPs had average size of 21.4 nm, spherical morphology, and were highly stable and pure. The characterized nanoparticles were exploited for a broad range of biomedical applications including bacteriocidal, fungicidal, leishmanicidal,\n                    <jats:italic>in vitro<\/jats:italic>\n                    antialzheimer\u2019s, antioxidant, anti-diabetic and biocompatibility studies. Our findings showed that\n                    <jats:italic>F. velutipes<\/jats:italic>\n                    mediated AgNPs exhibited high activity against MDR bacterial strains and spore forming fungal strains. All the tested urinary tract infection bacterial isolates, were resistant to non-coated antibiotics but by applying 1% of the synthesized AgNPs, the bactericidal potential of the tested antibiotics enhanced manifolds. The NPs also exhibited dose-dependent cytotoxic potential against\n                    <jats:italic>Leishmania tropica<\/jats:italic>\n                    with significant LC\n                    <jats:sub>50<\/jats:sub>\n                    of 248\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:italic>promastigote<\/jats:italic>\n                    and 251\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:italic>amastigote<\/jats:italic>\n                    forms of the parasite. Furthermore, promising antialzheimer and antidiabetic activities were observed as significant inhibition of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -amylase,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -glucosidase, acetylcholinesterase (AChE) and butrylcholineterase (BChE) were noted. Moreover, remarkable biocompatible nature of the particles was found against human red blood cells. The biosynthesized AgNPs as photocatalyst, also resulted in 98.2% degradation of indigo carmine dye within 140 min. Owing to ecofriendly synthesis, biosafe nature and excellent physicochemical properties\n                    <jats:italic>F. velutipes<\/jats:italic>\n                    AgNPs can be exploited as novel candidates for multifaceted biomedical and environmental applications.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/abc2eb","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T12:35:45Z","timestamp":1603974945000},"page":"065101","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":82,"title":["Edible mushroom (\n                    <i>Flammulina velutipes<\/i>\n                    ) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications"],"prefix":"10.1088","volume":"32","author":[{"given":"Shah","family":"Faisal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Aslam","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7225-2595","authenticated-orcid":false,"given":"Hasnain","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad Ali","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3549-5045","authenticated-orcid":false,"family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaira","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Rizwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Wajidullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Taj","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Redaina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"nanoabc2ebbib1","first-page":"18","type":"journal-article","volume":"10","author":"Verma","year":"2019","journal-title":"Int. J. Nano Dimension"},{"key":"nanoabc2ebbib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109740","type":"journal-article","volume":"103","author":"Muhammad","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"nanoabc2ebbib3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.carbpol.2018.05.069","type":"journal-article","volume":"197","author":"Zhang","year":"2018","journal-title":"Carbohydrate Polym."},{"key":"nanoabc2ebbib4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jare.2015.02.007","type":"journal-article","volume":"7","author":"Ahmed","year":"2016","journal-title":"J. Adv. Res."},{"key":"nanoabc2ebbib5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.arabjc.2010.04.008","type":"journal-article","volume":"3","author":"El-Nour","year":"2010","journal-title":"Arab. J. Chem."},{"key":"nanoabc2ebbib6","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3390\/nano8090681","type":"journal-article","volume":"8","author":"Burdu\u015fel","year":"2018","journal-title":"Nanomaterials"},{"key":"nanoabc2ebbib7","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1591\/aab37a","type":"journal-article","volume":"5","author":"Kalaivani","year":"2018","journal-title":"Mater. Res. Express"},{"key":"nanoabc2ebbib8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12951-018-0334-5","type":"journal-article","volume":"16","author":"Siddiqi","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"nanoabc2ebbib9","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1080\/21691401.2016.1241792","type":"journal-article","volume":"45","author":"Rafique","year":"2017","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"key":"nanoabc2ebbib10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4236\/gsc.2016.61004","type":"journal-article","volume":"6","author":"Srikar","year":"2016","journal-title":"Green Sustain. Chem."},{"key":"nanoabc2ebbib11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12888-015-0681-9","type":"journal-article","volume":"15","author":"Wei","year":"2015","journal-title":"BMC Psychiatry"},{"key":"nanoabc2ebbib12","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.chemosphere.2019.07.035","type":"journal-article","volume":"235","author":"Abdel-Aziz","year":"2019","journal-title":"Chemosphere"},{"key":"nanoabc2ebbib13","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1021\/acsenergylett.7b01104","type":"journal-article","volume":"3","author":"Zhao","year":"2018","journal-title":"ACS Energy Lett."},{"key":"nanoabc2ebbib14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0007-1536(80)80200-2","type":"journal-article","volume":"75","author":"Ingold","year":"1980","journal-title":"Trans. Br. Mycol. Soc."},{"key":"nanoabc2ebbib15","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/nnano.2011.145","type":"journal-article","volume":"6","author":"Holzwarth","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"nanoabc2ebbib16","doi-asserted-by":"publisher","first-page":"L30","DOI":"10.1093\/mnrasl\/slt106","type":"journal-article","volume":"436","author":"Morais","year":"2013","journal-title":"Mon. Not. R. Astron. Soc."},{"key":"nanoabc2ebbib17","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.arabjc.2017.07.004","type":"journal-article","volume":"13","author":"Khalil","year":"2020","journal-title":"Arab. J. Chem."},{"key":"nanoabc2ebbib18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1080\/14786419.2018.1437428","type":"journal-article","volume":"33","author":"Zohra","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"nanoabc2ebbib19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/21691401.2017.1337031","type":"journal-article","volume":"46","author":"Saratale","year":"2018","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"key":"nanoabc2ebbib20","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.3390\/molecules25092201","type":"journal-article","volume":"25","author":"Usman","year":"2020","journal-title":"Molecules"},{"key":"nanoabc2ebbib21","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110889","type":"journal-article","volume":"112","author":"Shah","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"nanoabc2ebbib22","first-page":"1","type":"journal-article","volume":"247","author":"Aziz","year":"2020","journal-title":"Mol. Diversity"},{"key":"nanoabc2ebbib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14786419.2018.1437427","type":"journal-article","volume":"33","author":"Ahmed","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"nanoabc2ebbib24","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201900509","type":"journal-article","volume":"17","author":"Aziz","year":"2020","journal-title":"Chem. Biodiversity"},{"key":"nanoabc2ebbib25","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.foodchem.2009.10.030","type":"journal-article","volume":"120","author":"Tagliazucchi","year":"2010","journal-title":"Food Chem."},{"key":"nanoabc2ebbib26","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1080\/17518253.2017.1339831","type":"journal-article","volume":"10","author":"Khalil","year":"2017","journal-title":"Green Chem. Lett. Rev."},{"key":"nanoabc2ebbib27","doi-asserted-by":"publisher","first-page":"19219","DOI":"10.1039\/D0RA01971B","type":"journal-article","volume":"10","author":"Jan","year":"2020","journal-title":"RSC Adv."},{"key":"nanoabc2ebbib28","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.carbpol.2016.03.071","type":"journal-article","volume":"146","author":"Lin","year":"2016","journal-title":"Carbohydrate Polym."},{"key":"nanoabc2ebbib29","doi-asserted-by":"publisher","first-page":"7265","DOI":"10.1021\/jf8008553","type":"journal-article","volume":"56","author":"Kim","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"nanoabc2ebbib30","doi-asserted-by":"publisher","first-page":"403023","DOI":"10.1155\/2015\/403023","type":"journal-article","volume":"2015","author":"Rahman","year":"2015","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"nanoabc2ebbib31","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.arabjc.2014.11.015","type":"journal-article","volume":"8","author":"Padalia","year":"2015","journal-title":"Arab. J. Chem."},{"key":"nanoabc2ebbib32","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.msec.2015.08.018","type":"journal-article","volume":"58","author":"Dhand","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"nanoabc2ebbib33","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3389\/fbioe.2019.00287","type":"journal-article","volume":"7","author":"Guilger-Casagrande","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"nanoabc2ebbib34","first-page":"181","type":"journal-article","volume":"6","author":"Mallikarjuna","year":"2011","journal-title":"Dig. J. Nanomater. Biostruct."},{"key":"nanoabc2ebbib35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/2228-5547-4-29","type":"journal-article","volume":"4","author":"Awwad","year":"2013","journal-title":"Int. J. Ind. Chem."},{"key":"nanoabc2ebbib36","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.colsurfb.2013.03.017","type":"journal-article","volume":"108","author":"Prakash","year":"2013","journal-title":"Colloids Surf. B"},{"key":"nanoabc2ebbib37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.saa.2012.11.075","type":"journal-article","volume":"104","author":"Das","year":"2013","journal-title":"Spectrochim. Acta A"},{"key":"nanoabc2ebbib38","first-page":"1","type":"journal-article","volume":"31","author":"Jenifer","year":"2019","journal-title":"J. Cluster Sci."},{"key":"nanoabc2ebbib39","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.saa.2010.12.060","type":"journal-article","volume":"78","author":"Philip","year":"2011","journal-title":"Spectrochim. Acta A"},{"key":"nanoabc2ebbib40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2020.101567","type":"journal-article","volume":"24","author":"Renuka","year":"2020","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"nanoabc2ebbib41","first-page":"37","type":"journal-article","volume":"10","author":"Adebayo-Tayo","year":"2019","journal-title":"Int. J. Nano Dimens."},{"key":"nanoabc2ebbib42","doi-asserted-by":"publisher","first-page":"91","DOI":"10.2147\/IJN.S125010","type":"journal-article","volume":"13","author":"Radhakrishnan","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"nanoabc2ebbib43","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1590\/S0036-46652015000200011","type":"journal-article","volume":"57","author":"Mallmann","year":"2015","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"nanoabc2ebbib44","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10658-014-0399-4","type":"journal-article","volume":"140","author":"Narayanan","year":"2014","journal-title":"Eur. J. Plant Pathol."},{"key":"nanoabc2ebbib45","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S1359-6446(02)02290-0","type":"journal-article","volume":"7","author":"Scapin","year":"2002","journal-title":"Drug Discovery Today"},{"key":"nanoabc2ebbib46","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.tet.2017.12.048","type":"journal-article","volume":"74","author":"Zhou","year":"2018","journal-title":"Tetrahedron"},{"key":"nanoabc2ebbib47","doi-asserted-by":"publisher","first-page":"5386129","DOI":"10.1155\/2018\/5386129","type":"journal-article","volume":"2018","author":"Nair","year":"2018","journal-title":"J. Thyroid Res."},{"key":"nanoabc2ebbib48","doi-asserted-by":"publisher","first-page":"9317987","DOI":"10.1155\/2018\/9317987","type":"journal-article","volume":"2018","author":"Aynalem","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"nanoabc2ebbib49","doi-asserted-by":"publisher","first-page":"40162","DOI":"10.1039\/C5RA24391B","type":"journal-article","volume":"6","author":"Balan","year":"2016","journal-title":"RSC Adv."},{"key":"nanoabc2ebbib50","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s40097-016-0200-7","type":"journal-article","volume":"6","author":"Senthilkumar","year":"2016","journal-title":"J. Nanostruct. Chem."},{"key":"nanoabc2ebbib51","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.foodres.2014.11.030","type":"journal-article","volume":"67","author":"Prieto","year":"2015","journal-title":"Food Res. Int."},{"key":"nanoabc2ebbib52","doi-asserted-by":"publisher","author":"Skonieczna","year":"2018","DOI":"10.5772\/intechopen.77075","type":"book"},{"key":"nanoabc2ebbib53","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3390\/medicina55070369","type":"journal-article","volume":"55","author":"Nasar","year":"2019","journal-title":"Medicina"},{"key":"nanoabc2ebbib54","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.nantod.2015.04.002","type":"journal-article","volume":"10","author":"Le Ouay","year":"2015","journal-title":"Nano Today"},{"key":"nanoabc2ebbib55","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1007\/s11051-008-9428-6","type":"journal-article","volume":"10","author":"Mart\u00ednez-Casta\u00f1on","year":"2008","journal-title":"J. Nanopart. Res."},{"key":"nanoabc2ebbib56","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1128\/AEM.02218-06","type":"journal-article","volume":"73","author":"Pal","year":"2007","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Nanotechnology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T15:33:37Z","timestamp":1763220817000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/abc2eb"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,11,18]]},"published-print":{"date-parts":[[2021,2,5]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6528\/abc2eb","relation":{},"ISSN":["0957-4484","1361-6528"],"issn-type":[{"value":"0957-4484","type":"print"},{"value":"1361-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]},"assertion":[{"value":"Edible mushroom (\n                      Flammulina velutipes\n                      ) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications","name":"article_title","label":"Article Title"},{"value":"Nanotechnology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-08-22","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-10-20","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-11-18","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}