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Initially, the influence of deacetylation degree (DD) of chitosan and ionic gelation methods on the properties of NPs was studied. High DD (95%) chitosan was attributed to higher encapsulation efficiency and stability when crosslinked with polyanion tripolyphosphate. Subsequently, the multi-unit system was fabricated using a pH-sensitive polymer (sodium alginate) as the coating layer to further encapsulate the NP. Fiber mat with an average diameter of 481\u00a0\u00b1\u00a047 nm could significantly decrease the burst release of insulin in acidic condition and release most amount of insulin (&gt;60%) in the simulated intestinal medium. Furthermore, the encapsulated peptide remained in good integrity. This multi-unit carrier provides the better-designed vehicle for intestinal-specific delivery and controlled release of the peptide.<\/jats:p>","DOI":"10.1088\/1361-6528\/abed07","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T17:30:50Z","timestamp":1615311050000},"page":"245101","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Fabrication of nanostructured multi-unit vehicle for intestinal-specific delivery and controlled release of peptide"],"prefix":"10.1088","volume":"32","author":[{"given":"Kun","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Shan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Hua","family":"Zong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng-Gen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-9979","authenticated-orcid":false,"given":"Hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang-Yan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"nanoabed07bib1","first-page":"167","type":"journal-article","article-title":"Bioactive peptides: its production and potential role on health","volume":"7","author":"Patil","year":"2020","journal-title":"Innov. 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