{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:01:08Z","timestamp":1792785668873,"version":"4.5.0"},"reference-count":43,"publisher":"IOP Publishing","issue":"43","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Department of Science & Technology (DST), India","award":["DST Nano Mission grant DST\/ NM\/ NT\/2020\/322DST\/ NM"],"award-info":[{"award-number":["DST Nano Mission grant DST\/ NM\/ NT\/2020\/322DST\/ NM"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2023,10,23]]},"abstract":"Abstract<\/jats:title>\n \n Cholesterol (CH) is a vital diagnostic marker for a variety of diseases, making its detection crucial in biological applications including clinical practice. In this work, we report the synthesis of tin oxide-polyaniline nanocomposite-modified nickel foam (SnO\n 2<\/jats:sub>\n -PANI\/NF) for non-enzymatic detection of CH in simulated human blood serum. SnO\n 2<\/jats:sub>\n was synthesized via the hydrothermal method, followed by the synthesis of SnO\n 2<\/jats:sub>\n -PANI nanocomposite through\n in situ<\/jats:italic>\n chemical polymerization of aniline using ammonium persulfate as the oxidizing agent. Morphological studies display agglomerated SnO\n 2<\/jats:sub>\n -PANI, which possess diameters ranging from an average particle size of \u223c50 to \u223c500 nm, and the XRD analysis revealed the tetragonal structure of the SnO\n 2<\/jats:sub>\n -PANI nanocomposite. Optimization studies demonstrating the effect of pH and weight percentage are performed to improve the electrocatalytic performance of the sensor. The non-enzymatic SnO\n 2<\/jats:sub>\n -PANI\/NF sensor exhibits a linear range of 1\u2013100\n \u03bc<\/jats:italic>\n M with a sensitivity of 300\n \u03bc<\/jats:italic>\n A\n \u03bc<\/jats:italic>\n M\n \u22121<\/jats:sup>\n \/cm\n \u22122<\/jats:sup>\n towards CH sensing and a low limit of detection of 0.25\n \u03bc<\/jats:italic>\n M (=3 S m\n \u22121<\/jats:sup>\n ). SnO\n 2<\/jats:sub>\n -PANI\/NF facilitates the electrooxidation of CH to form cholestenone by accepting electrons generated during the reaction and transferring them to the nickel foam electrode via Fe (III)\/Fe (IV) conversion, resulting in an increased electrochemical current response. The SnO\n 2<\/jats:sub>\n -PANI\/NF sensor demonstrated excellent selectivity against interfering species such as Na\n +<\/jats:sup>\n , Cl\n \u2212<\/jats:sup>\n , K\n +<\/jats:sup>\n , glucose, ascorbic acid, and SO\n 4<\/jats:sub>\n 2\u2212<\/jats:sup>\n . The sensor successfully determined the concentration of CH in simulated blood serum samples, demonstrating SnO\n 2<\/jats:sub>\n -PANI as a potential platform for a variety of electrochemical-based bioanalytical applications.\n <\/jats:p>","DOI":"10.1088\/1361-6528\/acea2a","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T05:44:54Z","timestamp":1691473494000},"page":"435501","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Tin oxide-polyaniline nanocomposite modified nickel foam for highly selective and sensitive detection of cholesterol in simulated blood serum samples"],"prefix":"10.1088","volume":"34","author":[{"given":"Pratiksha","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sreekumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-3031","authenticated-orcid":false,"given":"Sushmee","family":"Badhulika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"nanoacea2abib1","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s42255-020-0174-0","type":"journal-article","article-title":"Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities","volume":"2","author":"Huang","year":"2020","journal-title":"Nat. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2023-05-17","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2023-07-25","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2023-08-09","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}