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Topical products containing depigmenting agents offer a less aggressive treatment option for hyperpigmentation compared to methods like chemical peels and laser sessions. However, some of these agents can cause side effects such as redness and skin irritation. Encapsulating these actives in nanosystems shows promise in mitigating these effects and improving product safety and efficacy. In addition, nanocarriers have the ability to penetrate the skin, potentially allowing for targeted delivery of actives to the affected areas. The most commonly investigated nanosystems are nanoemulsions, vesicular nanosystems and nanoparticles, in which different materials can be used to generate different compositions in order to improve the properties of these nanocarriers. Nanocarriers have already been widely explored, but it is necessary to understand the evolution of these technologies when applied to the treatment of skin hyperchromias. Therefore, this literature review aims to present the state of the art over the last 15 years on the use of nanosystems as a potential strategy for encapsulating depigmenting actives for potential application in cosmetic products for skin hyperchromia. By providing a comprehensive overview of the latest research findings and technological advances, this article can contribute to improving the care and quality of life of people affected by this skin condition.<\/jats:p>","DOI":"10.1088\/1361-6528\/ad5a15","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T18:21:18Z","timestamp":1718907678000},"page":"402001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Nanosystems with potential application as carriers for skin depigmenting actives"],"prefix":"10.1088","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9535-2022","authenticated-orcid":true,"given":"Natalia Ruben","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-4547","authenticated-orcid":true,"given":"Cristal Dos Santos C","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-0643","authenticated-orcid":false,"given":"Elisabete P","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-7363","authenticated-orcid":false,"given":"Claudia Regina E","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"nanoad5a15bib1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/jidsymp.2008.7","article-title":"Latest insights into skin hyperpigmentation","volume":"13","author":"Ortonne","year":"2008","journal-title":"J. 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