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Additionally, we evaluated physicochemical properties, including dynamic light scattering, zeta potential analysis, drug loading capacity (DLC), and drug loading efficiency (DLE). The impact of NPs on the mouse colorectal cancer cell line (CT26) and NIH3T3 cells was assessed using a cytotoxicity assay, live\/dead staining assay, flow cytometry, and confocal fluorescence microscopy. The experimental results align with the expected chemical structure and physicochemical properties of poly(tetraethylene glycol) NPs. These NPs exhibit high DLE (78.7%) and DLC (12%), with minimal changes in particle size over time in different media. <jats:italic>In vitro<\/jats:italic> experiments revealed that the NPs can induce significant cytotoxicity and apoptosis in CT26 cells. Cellular uptake notably increases with increasing concentration and exposure time. The confocal microscopic analysis confirmed the effective distribution and accumulation of NPs within cells. In conclusion, poly(tetraethylene glycol) NPs hold promise for improving drug-delivery efficiency, offering potential advancements in cancer treatment.<\/jats:p>","DOI":"10.1088\/1361-6528\/ad7c54","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T22:47:58Z","timestamp":1726699678000},"page":"495707","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["pH-sensitive and redox-responsive poly(tetraethylene glycol) nanoparticle-based platform for cancer treatment"],"prefix":"10.1088","volume":"35","author":[{"given":"Qian","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2367-6414","authenticated-orcid":true,"given":"Nuocheng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qimeng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aili","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9734-0655","authenticated-orcid":true,"given":"Xianming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"nanoad7c54bib1","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.7150\/thno.57828","article-title":"Recent progress in nanomedicine for enhanced cancer chemotherapy","volume":"11","author":"Wei","year":"2021","journal-title":"Theranostics"},{"key":"nanoad7c54bib2","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ccell.2022.01.006","article-title":"Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy","volume":"40","author":"Vincent","year":"2022","journal-title":"Cancer Cell"},{"key":"nanoad7c54bib3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3322\/caac.21273","article-title":"Improving the outcome for children with cancer: development of targeted new agents","volume":"65","author":"Adamson","year":"2015","journal-title":"CA Cancer J. 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