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However, its poor water solubility and low bioavailability limit its effectiveness. To address this, we developed SF@DEX nanomaterials and investigated their therapeutic potential and mechanisms in RD. The nanomaterials were successfully synthesized and characterized, achieving 90% encapsulation efficiency and releasing 60% of DEX within 12 h.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , phagocytosis was measured by flow cytometry, and enzyme-linked immunosorbent assay determined interleukin-17 (IL-17) and interleukin-10 (IL-10) levels. A rat RD model was established surgically, followed by oral administration of silk fibroin (SF), SF@DEX, and DEX. Polymerase chain reaction (PCR) assessed IL-17A and forkhead box P3 (FOXP3) expression, while Western blot analysed transforming growth factor-\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 (TGF-\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1), IL-10, IL-17A, and FOXP3 levels. Apoptosis of retinal ganglion cells was evaluated using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, and confocal microscopy detected colocalization of IL-17A and FOXP3. SF@DEX treatment significantly reduced Th17 cells and IL-17A while increasing Tregs, FOXP3, TGF-\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1, and IL-10 levels. The severity of RD in rats was notably alleviated by SF@DEX, demonstrating its anti-inflammatory effects through modulation of the Th17\/Treg immune balance. These results highlight SF@DEX as a promising nano-based therapy for RD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:inline-formula\/>\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/ad9df2","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T17:48:23Z","timestamp":1734025703000},"page":"115101","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dexamethasone-loaded fibroin nanoparticles promote retinal reattachment in rats by regulating the Th17\/Treg balance"],"prefix":"10.1088","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-6959","authenticated-orcid":true,"given":"Linfeng","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genjie","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghong","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7986-3606","authenticated-orcid":true,"given":"Liming","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"nanoad9df2bib1","first-page":"161","article-title":"Rhegmatogenous retinal detachment and conventional surgical treatment","volume":"34","author":"Golubovic","year":"2013","journal-title":"Prilozi\/Makedonska akademija na naukite i umetnostite, Oddelenie za biolo\u0161ki i medicinski nauki = Contributions\/Macedonian Acad. 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