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By improving these properties, such systems offer better clinical outcomes, reduced systemic toxicity, and expanded therapeutic options, particularly for cancers that exhibit resistance to conventional treatments. In this context, nanogel-based delivery platforms constructed from Brij S100 grafted with alginate have demonstrated considerable promise. Two formulations were studied: Brij\u2013Alg and Brij\u2013Alg\u2013Tau, the latter featuring surface modification of Brij\u2013Alg nanogel particles with taurine molecules. These nanogels were used to encapsulate the anti-cancer drug cisplatin. The resulting drug-loaded nanogels exhibited desirable physicochemical characteristics, including optimal particle size, morphology, surface charge, and controlled drug release profiles suitable for targeted drug delivery applications. Importantly, both Brij\u2013Alg and Brij\u2013Alg-Tau nanogels displayed excellent biocompatibility, with minimal cytotoxicity toward fibroblast cells, indicating their safety for biological use. Cytotoxicity assay against the HeLa cervical cancer cell line revealed that Brij\u2013Alg\u2013Tau\/CIS nanogels induced significantly greater cell death than both free CIS and Brij\u2013Alg\/CIS nanogels. The enhanced cytotoxicity is attributed to improved cellular uptake and sustained drug release enabled by the taurine-functionalized nanogel structure. These findings suggest that Brij\u2013Alg\u2013Tau nanogels are a promising vehicle for CIS delivery and hold strong potential for advancing cervical cancer therapy.<\/jats:p>","DOI":"10.1088\/1361-6528\/ae0cd1","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T22:47:52Z","timestamp":1759186072000},"page":"415601","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced cytotoxicity of cisplatin-loaded Brij S100-alginate-taurine nanogels against HeLa cervical cancer cells"],"prefix":"10.1088","volume":"36","author":[{"given":"Phuong","family":"Le Thi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoai Tam","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viet","family":"Quoc Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha","family":"Tran Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien","family":"Thinh Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-1847","authenticated-orcid":true,"given":"Van Toan","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"nanoae0cd1bib1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.703559","type":"journal-article","article-title":"Self-assembled nanogels based on ionic gelation of natural polysaccharides for drug delivery","volume":"9","author":"Wang","year":"2021","journal-title":"Front. 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