{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:23:47Z","timestamp":1791329027694,"version":"4.3.1"},"reference-count":200,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Colon cancer is one of the leading cancers worldwide, with standard treatments hindered by inadequate targeting and toxicities that limit dosage. Nanotechnology offers a revolutionary framework for targeted drug delivery, utilizing nanoscale effects to improve treatment accuracy. This examination focuses on chitosan nanoparticles (CNPs) as innovative nanocarriers, leveraging their unique nanoscale features like sizes between 50\u2013300 nm, elevated surface-to-volume ratios, and positive zeta potentials (+20 to +50 mV) to facilitate mucoadhesive interactions and improved passage through biological barriers. We emphasize novel synthesis methods, such as ionic gelation utilizing tripolyphosphate for creating particles under 100 nm and eco-friendly techniques with plant extracts for sustainable scalability, enabling accurate regulation of polydispersity indices (&lt;0.2) and drug encapsulation efficiencies (&gt;80%). Functionalization of surfaces with ligands (such as folate or hyaluronic acid) promotes receptor-mediated endocytosis, leveraging quantum confinement-like effects in surface charge distribution to enhance cellular uptake in colon cancer receptors that are overexpressed. Preclinical findings demonstrate stimulus-responsive actions, including pH-activated disassembly in the acidic tumor milieu (pH 5.5\u20136.5) or enzyme-facilitated release by colonic glycosidases, resulting in prolonged drug payloads (like 5-fluorouracil or curcumin) with 2\u20135 times greater bioavailability and minimized off-target impacts. Incorporating magnetic or fluorescent elements allows for multifunctional theranostics that merge nanoscale imaging with therapeutic applications. Despite challenges in mass production and in vivo stability, continuous progress in nanoscale enhancements is set to close preclinical gaps, establishing CNPs as a fundamental element for future colon cancer treatments through quantum-inspired precision and biocompatibility.<\/jats:p>","DOI":"10.1088\/1361-6528\/ae2a3d","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T22:47:57Z","timestamp":1765320477000},"page":"012001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Precision nanoscale engineering of chitosan nanoparticles via ionic gelation, eco-friendly synthesis, and ligand functionalization for improved targeted drug delivery in colon cancer treatment"],"prefix":"10.1088","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9904-5449","authenticated-orcid":true,"given":"Apurv Nandalal","family":"Shimpi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9424-5064","authenticated-orcid":true,"given":"Yash Dhananand","family":"Sonawane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-9582","authenticated-orcid":true,"given":"Sankha","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"nanoae2a3dbib1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.112249","type":"journal-article","article-title":"HMMR is a novel prognostic marker and a potential therapeutic target for colon cancer","volume":"138","author":"Fang","year":"2026","journal-title":"Cell. Signalling"},{"key":"nanoae2a3dbib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2025.117606","type":"journal-article","article-title":"The glutamyl-prolyl-tRNA synthetase 1 inhibitor halofuginone exerts synergistic antitumor effects with bortezomib in colon cancer cells","volume":"506","author":"Lin","year":"2026","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"nanoae2a3dbib3","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/hed.27207","type":"journal-article","article-title":"Role of sentinel lymph node biopsy for oral squamous cell carcinoma: current evidence and future challenges","volume":"45","author":"Jang","year":"2023","journal-title":"Head Neck"},{"key":"nanoae2a3dbib4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2025.116727","type":"journal-article","article-title":"The influence of neoadjuvant chemotherapy cycles on surgical complications in metastatic colon cancer","volume":"252","author":"Chang","year":"2026","journal-title":"Am. J. Surg."},{"key":"nanoae2a3dbib5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3322\/caac.21772","type":"journal-article","article-title":"Colorectal cancer statistics","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"nanoae2a3dbib6","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3322\/caac.21631","type":"journal-article","article-title":"Treatment of muscle-invasive and advanced bladder cancer in 2020","volume":"70","author":"Patel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"nanoae2a3dbib7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1136\/gutjnl-2020-321000","type":"journal-article","article-title":"Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer","volume":"70","author":"Knudsen","year":"2021","journal-title":"Gut"},{"key":"nanoae2a3dbib8","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1001\/jama.2021.0106","type":"journal-article","article-title":"Diagnosis and treatment of metastatic colorectal cancer: a review","volume":"325","author":"Biller","year":"2021","journal-title":"JAMA"},{"key":"nanoae2a3dbib9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41392-020-0116-z","type":"journal-article","article-title":"Comprehensive review of targeted therapy for colorectal cancer","volume":"5","author":"Xie","year":"2020","journal-title":"Curr. Signal Transduct. Ther."},{"key":"nanoae2a3dbib10","doi-asserted-by":"publisher","first-page":"458","DOI":"10.14309\/ajg.0000000000001122","type":"journal-article","article-title":"ACG clinical guidelines: colorectal cancer screening 2021","volume":"116","author":"Shaukat","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"nanoae2a3dbib11","article-title":"Advances in nanoparticle-based targeted drug delivery systems for colorectal cancer therapy: a review","author":"Hasan","year":"2024","type":"other"},{"key":"nanoae2a3dbib12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.22159\/ijap.2024v16i2.49293","type":"journal-article","article-title":"A review on development of colon targeted drug delivery system","volume":"16","author":"Muhammed","year":"2024","journal-title":"Int. J. Appl. Pharm."},{"key":"nanoae2a3dbib13","doi-asserted-by":"publisher","first-page":"734","DOI":"10.3390\/pharmaceutics16060734","type":"journal-article","article-title":"Review of prodrug and nanodelivery strategies to improve the treatment of colorectal cancer with fluoropyrimidine drugs","volume":"16","author":"Sarkar","year":"2024","journal-title":"Pharmaceutics"},{"key":"nanoae2a3dbib14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1460201","type":"journal-article","article-title":"Global research progress of nanomedicine and colorectal cancer: a bibliometrics and visualization analysis","volume":"14","author":"Tian","year":"2024","journal-title":"Front. Oncol."},{"key":"nanoae2a3dbib15","first-page":"2525","type":"journal-article","article-title":"Advances in colon-targeted drug delivery systems: innovative strategies for treating colonic disorders and prospects for the future","volume":"25","author":"Singh","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"nanoae2a3dbib16","type":"journal-article","article-title":"Strategic approaches for colon targeted drug delivery: an overview of recent advancements","volume":"12","author":"Lee","year":"2020","journal-title":"Pharmaceutics"},{"key":"nanoae2a3dbib17","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1582659","type":"journal-article","article-title":"Targeted and intelligent nano-drug delivery systems for colorectal cancer treatment","volume":"13","author":"Chai","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"nanoae2a3dbib18","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12645-025-00339-w","type":"journal-article","article-title":"\u03b2-cyclodextrin-based multifunctional carriers for colon-targeted drug delivery: advances in hydrogel systems and mucoadhesive strategies","volume":"16","author":"Sharma","year":"2025","journal-title":"Cancer Nanotechnol."},{"key":"nanoae2a3dbib19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.139177","type":"journal-article","article-title":"Polysaccharide-based drug delivery targeted approach for colon cancer treatment: a comprehensive review","volume":"302","author":"Shao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib20","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1208\/s12249-024-02965-w","type":"journal-article","article-title":"Advancements in colon-targeted drug delivery: a comprehensive review on recent techniques with emphasis on hot-melt extrusion and 3D printing technologies","volume":"25","author":"Alshammari","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"nanoae2a3dbib21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12951-025-03252-x","type":"journal-article","article-title":"Metal\u2013organic framework-based smart stimuli-responsive drug delivery systems for cancer therapy: advances, challenges, and future perspectives","volume":"23","author":"Guo","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"nanoae2a3dbib22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.smaim.2020.04.001","type":"journal-article","article-title":"Nanoparticle-based drug delivery systems for cancer therapy","volume":"1","author":"Dang","year":"2020","journal-title":"Smart Mater. Med."},{"key":"nanoae2a3dbib23","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1080\/10717544.2022.2089296","type":"journal-article","article-title":"Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems","volume":"29","author":"Bajracharya","year":"2022","journal-title":"Drug. Deliv."},{"key":"nanoae2a3dbib24","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3390\/pharmaceutics17030381","type":"journal-article","article-title":"Oral bioavailability enhancement of anti-cancer drugs through lipid polymer hybrid nanoparticles","volume":"17","author":"Almawash","year":"2025","journal-title":"Pharmaceutics"},{"key":"nanoae2a3dbib25","first-page":"115","type":"book","article-title":"Polymeric nanoparticles in colon targeting","author":"Mishra","year":"2025"},{"key":"nanoae2a3dbib26","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/s12951-024-02701-3","type":"journal-article","article-title":"Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges","volume":"22","author":"Narayana","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"nanoae2a3dbib27","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jconrel.2024.04.005","type":"journal-article","article-title":"Self-adjuvanting polymeric nanovaccines enhance IFN production and cytotoxic T cell response","volume":"369","author":"Zhao","year":"2024","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib28","article-title":"Mesoporous silica nanoparticles-based smart nanocarriers for targeted drug delivery in colorectal cancer therapy","author":"Mann","year":"2024","type":"preprint"},{"key":"nanoae2a3dbib29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125562","type":"journal-article","article-title":"Harnessing unique architecture and emerging strategies of solid lipid nanoparticles to combat colon cancer: a state-of-the-art review","volume":"675","author":"Gupta","year":"2025","journal-title":"Int. J. Pharm."},{"key":"nanoae2a3dbib30","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3390\/nano15030182","type":"journal-article","article-title":"The convergence of nanotechnology and biotechnology in modern medicine","volume":"15","author":"Fernandes","year":"2025","journal-title":"Nanomaterials"},{"key":"nanoae2a3dbib31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.107564","type":"journal-article","article-title":"Formulation matters: assessment of the correlation between mucoadhesiveness and type of chitosan formulation for vaginal application","volume":"114","author":"Mork","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"nanoae2a3dbib32","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2025.128650","type":"journal-article","article-title":"Mucoadhesive chitosan-modified PLGA nanoparticles loaded with green tea extract inhibit amyloid \u03b2 peptide aggregation and oxidative stress","volume":"437","author":"Andrade","year":"2025","journal-title":"J. Mol. Liq."},{"key":"nanoae2a3dbib33","doi-asserted-by":"publisher","first-page":"4328","DOI":"10.3390\/molecules28114328","type":"journal-article","article-title":"A simple method for synthesis of chitosan nanoparticles with ionic gelation and homogenization","volume":"28","author":"Van Bavel","year":"2023","journal-title":"Molecules"},{"key":"nanoae2a3dbib34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13036-024-00403-w","type":"journal-article","article-title":"Optimize the parameters for the synthesis by the ionic gelation technique, purification, and freeze-drying of chitosan-sodium tripolyphosphate nanoparticles for biomedical purposes","volume":"18","author":"Guti\u00e9rrez-Ru\u00edz","year":"2024","journal-title":"J. Biol. Eng."},{"key":"nanoae2a3dbib35","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3390\/antiox11030479","type":"journal-article","article-title":"Chitosan-tripolyphosphate nanoparticles prepared by ionic gelation improve the antioxidant activities of astaxanthin in the in vitro and in vivo model","volume":"11","author":"Kim","year":"2022","journal-title":"Antioxidants"},{"key":"nanoae2a3dbib36","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.3390\/polym17111453","type":"journal-article","article-title":"Chitosan nanoparticle-based drug delivery systems: advances, challenges, and future perspectives","volume":"17","author":"Stefanache","year":"2025","journal-title":"Polymers"},{"key":"nanoae2a3dbib37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.147441","type":"journal-article","article-title":"Review of engineered magnetic chitosan nanoparticles for drug delivery: advances, challenges, and future prospects","volume":"327","author":"Pareek","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142832","type":"journal-article","article-title":"Chitosan, derivatives, and its nanoparticles: preparation, physicochemical properties, biological activities, and biomedical applications\u2014A comprehensive review","volume":"313","author":"El-Saadony","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib39","type":"other","article-title":"Synthesis of chitosan nanoparticles (CSNP): effect of CH-CH-TPP ratio on size and stability of NPs","volume":"vol 12","author":"Des Bouillons-Gamboa","year":"2024"},{"key":"nanoae2a3dbib40","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.jconrel.2023.03.018","type":"journal-article","article-title":"Preventing ischemia-reperfusion injury by acousto-mechanical local oxygen delivery","volume":"356","author":"Ho","year":"2023","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib41","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ijbiomac.2022.05.041","type":"journal-article","article-title":"ASIC1a promotes hepatic stellate cell activation through the exosomal miR-301a-3p\/BTG1 pathway","volume":"211","author":"Luan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib42","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113206","type":"journal-article","article-title":"Capture and release of circulating tumor cells stimulated by pH and NIR irradiation of magnetic Fe3O4@ZIF-8 nanoparticles","volume":"224","author":"Wang","year":"2023","journal-title":"Colloids Surf. B"},{"key":"nanoae2a3dbib43","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s13205-024-04073-9","type":"journal-article","article-title":"Green synthesis of chitosan nanoparticles using Cassia fistula leaf extract: evaluation of antimicrobial, antioxidant, antibiofilm, and cytotoxic activities","volume":"14","author":"Ganesan","year":"2024","journal-title":"3 Biotech"},{"key":"nanoae2a3dbib44","type":"journal-article","article-title":"Recent advances and perspectives in functional chitosan-based composites for environmental remediation, energy, and biomedical applications","volume":"152","author":"Zhou","year":"2025","journal-title":"Prog. Mater. Sci."},{"key":"nanoae2a3dbib45","doi-asserted-by":"publisher","DOI":"10.1016\/j.enmm.2022.100691","type":"journal-article","article-title":"A metal free nanosensor based on nanocellulose-polypyrrole matrix and single-walled carbon nanotube: experimental study and electroanalytical application for determination of paracetamol and ciprofloxacin","volume":"18","author":"Shalauddin","year":"2022","journal-title":"Environ. Nanotechnol. Monit. Manage."},{"key":"nanoae2a3dbib46","first-page":"7579","type":"journal-article","article-title":"A review on sustainable iron oxide nanoparticles: syntheses and applications in organic catalysis and environmental remediation","volume":"26","author":"Chaudhari","year":"2024","journal-title":"Green Chem."},{"key":"nanoae2a3dbib47","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102358","type":"journal-article","article-title":"Chitosan nanoparticles: green synthesis, biological activities, and sustainable frontiers in targeted drug delivery and cancer nanomedicine\u2014A comprehensive review","volume":"35","author":"El-Saadony","year":"2025","journal-title":"Mater. Today Bio"},{"key":"nanoae2a3dbib48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtsust.2025.101195","type":"journal-article","article-title":"Harnessing plant extracts for green nanoparticle synthesis: toward a sustainable future","volume":"31","author":"Khan","year":"2025","journal-title":"Mater. Today Sustain."},{"key":"nanoae2a3dbib49","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.toxrep.2023.06.012","type":"journal-article","article-title":"Chitosan nanoparticle toxicity: a comprehensive literature review of in vivo and in vitro assessments for medical applications","volume":"11","author":"Zoe","year":"2023","journal-title":"Toxicol. Rep."},{"key":"nanoae2a3dbib50","type":"journal-article","article-title":"Ant and dissociation behavior of polypropylene-graft-maleic anhydride","volume":"139","author":"Redfearn","year":"2022","journal-title":"Polym. Chem."},{"key":"nanoae2a3dbib51","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114306","type":"journal-article","article-title":"Two-photon photodynamic therapy with curcumin nanocomposite","volume":"245","author":"Zhou","year":"2025","journal-title":"Colloids Surf. B"},{"key":"nanoae2a3dbib52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/21691401.2025.2462328","type":"journal-article","article-title":"In vivo toxicity of chitosan-based nanoparticles: a systematic review","volume":"53","author":"Salsabila","year":"2025","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"nanoae2a3dbib53","doi-asserted-by":"publisher","DOI":"10.1002\/app.52012","type":"journal-article","article-title":"Preparation, properties, and applications of modified polyurethane foam from persimmon tannin powder","volume":"139","author":"Shen","year":"2022","journal-title":"J. Appl. Polym. Sci."},{"key":"nanoae2a3dbib54","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s13726-021-00947-4","type":"journal-article","article-title":"Biocompatibility and histopathological evaluation of chitosan nanoparticles grafted fish gelatin bio-nanocomposite membranes in rats","volume":"30","author":"Dara","year":"2021","journal-title":"Iran. Polym. J."},{"key":"nanoae2a3dbib55","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2024.112983","type":"journal-article","article-title":"Advances in chitosan-based drug delivery systems: a comprehensive review for therapeutic applications","volume":"210","author":"Haider","year":"2024","journal-title":"Eur. Polym. J."},{"key":"nanoae2a3dbib56","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","type":"journal-article","article-title":"Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN","volume":"72","author":"Morgan","year":"2023","journal-title":"Gut"},{"key":"nanoae2a3dbib57","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","type":"journal-article","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"nanoae2a3dbib58","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s43046-025-00277-z","type":"journal-article","article-title":"Advances in colorectal cancer screening and detection: a narrative review on biomarkers, imaging and preventive strategies","volume":"37","author":"Khan","year":"2025","journal-title":"J. Egypt. Natl Cancer Inst."},{"key":"nanoae2a3dbib59","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s12885-025-13643-w","type":"journal-article","article-title":"Global burden of colorectal cancer attributable to metabolic risks from 1990 to 2021, with predictions to 2046","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Cancer"},{"key":"nanoae2a3dbib60","article-title":"The role of diet and lifestyle in colorectal cancer incidence and survival","author":"Vallis","year":"2022","type":"book"},{"key":"nanoae2a3dbib60","type":"book"},{"key":"nanoae2a3dbib61","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.3390\/nu14183745","type":"journal-article","article-title":"The lactobacillus gasseri G098 strain mitigates symptoms of DSS-induced inflammatory bowel disease in mice Nutrients","volume":"14","author":"Zhang","year":"2022"},{"key":"nanoae2a3dbib62","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147857","type":"journal-article","article-title":"Colorectal cancer: genetic alterations, novel biomarkers, current therapeutic strategies and clinical trials","volume":"892","author":"Housini","year":"2024","journal-title":"Gene"},{"key":"nanoae2a3dbib63","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41392-024-01848-7","type":"journal-article","article-title":"Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"nanoae2a3dbib64","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41392-024-01953-7","type":"journal-article","article-title":"Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"nanoae2a3dbib65","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115611","type":"journal-article","article-title":"Current advances in detecting genetic and epigenetic biomarkers of colorectal cancer","volume":"239","author":"Islam","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"nanoae2a3dbib66","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41571-019-0241-1","type":"journal-article","article-title":"Biomarker-guided therapy for colorectal cancer: strength in complexity","volume":"17","author":"Sveen","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"nanoae2a3dbib67","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1158\/1078-0432.CCR-23-3964","type":"journal-article","article-title":"Clinical challenges of consensus molecular subtype CMS4 colon cancer in the era of precision medicine","volume":"30","author":"Mouillet-Richard","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"nanoae2a3dbib68","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41586-024-07747-9","type":"journal-article","article-title":"The genomic landscape of 2,023 colorectal cancers","volume":"633","author":"Cornish","year":"2024","journal-title":"Nature"},{"key":"nanoae2a3dbib69","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3892\/ol.2023.13816","type":"journal-article","article-title":"Molecular subtyping in colorectal cancer: a bridge to personalized therapy (review)","volume":"25","author":"Wang","year":"2023","journal-title":"Oncol. Lett."},{"key":"nanoae2a3dbib70","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1093\/jnci\/djab106","type":"journal-article","article-title":"Clinical value of consensus molecular subtypes in colorectal cancer: a systematic review and meta-analysis","volume":"114","author":"ten Hoorn","year":"2021","journal-title":"J. Natl Cancer Inst."},{"key":"nanoae2a3dbib71","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1021\/acsptsci.4c00008","type":"journal-article","article-title":"Advances in precision medicine approaches for colorectal cancer: from molecular profiling to targeted therapies","volume":"7","author":"Kiran","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"nanoae2a3dbib72","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00428-024-03746-3","type":"journal-article","article-title":"Molecular pathological classification of colorectal cancer-an update","volume":"484","author":"Dunne","year":"2024","journal-title":"Virchows Arch."},{"key":"nanoae2a3dbib73","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1186\/s12935-025-03996-4","type":"journal-article","article-title":"An integrative analysis of transcriptome, methylome and single-cell RNA sequencing data identifies UBE2H as a marker of oxaliplatin resistance in colorectal cancer","volume":"25","author":"Fang","year":"2025","journal-title":"Cancer Cell Int."},{"key":"nanoae2a3dbib74","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1186\/s12964-024-01831-3","type":"journal-article","article-title":"Intratumoral microbiota in colorectal cancer: focus on specific distribution and potential mechanisms","volume":"22","author":"Long","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"nanoae2a3dbib75","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cpt.2025.06.007","type":"journal-article","article-title":"Emerging risk factors and the role of gut microbiota in immunomodulation and therapeutic implications in colorectal cancer","volume":"4","author":"Modeel","year":"2026","journal-title":"Cancer. Pathog. Ther."},{"key":"nanoae2a3dbib76","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1186\/s12885-023-11277-4","type":"journal-article","article-title":"Tumor microenvironment characterization in colorectal cancer to identify prognostic and immunotherapy genes signature","volume":"23","author":"Guo","year":"2023","journal-title":"BMC Cancer"},{"key":"nanoae2a3dbib77","doi-asserted-by":"publisher","first-page":"11149","DOI":"10.1002\/cam4.5698","type":"journal-article","article-title":"Role of tumor microenvironment in cancer progression and therapeutic strategy","volume":"12","author":"Wang","year":"2023","journal-title":"Cancer Med."},{"key":"nanoae2a3dbib78","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24585","type":"journal-article","article-title":"The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches","volume":"36","author":"Zafari","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"nanoae2a3dbib79","doi-asserted-by":"publisher","first-page":"7436","DOI":"10.1002\/anie.202014314","type":"journal-article","article-title":"Unconventional photocatalysis in conductive polymers: reversible modulation of PEDOT:PSS conductivity by long-lived poly(heptazine imide) radicals","volume":"60","author":"Savateev","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"nanoae2a3dbib80","first-page":"940","type":"journal-article","article-title":"ROS\/enzyme dual-responsive drug delivery system for targeted colorectal cancer therapy: synergistic chemotherapy, anti-inflammatory, and gut microbiota modulation","volume":"17","author":"Zhang","year":"2025","journal-title":"J. Contr. Release"},{"key":"nanoae2a3dbib81","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.1016\/j.apsb.2022.08.013","type":"journal-article","article-title":"Smart drug delivery systems for precise cancer therapy","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"nanoae2a3dbib82","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1016\/j.apsb.2022.03.013","type":"journal-article","article-title":"An integrative approach of digital image analysis and transcriptome profiling to explore potential predictive biomarkers for TGF\u03b2 blockade therapy","volume":"12","author":"Pomponio","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"nanoae2a3dbib83","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/s41420-025-02593-8","type":"journal-article","article-title":"Epithelial-mesenchymal transition in colorectal cancer metastasis and progression: molecular mechanisms and therapeutic strategies","volume":"11","author":"Nie","year":"2025","journal-title":"Cell Death Discov."},{"key":"nanoae2a3dbib84","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914815","type":"journal-article","article-title":"Role of epithelial to mesenchymal transition in colorectal cancer","volume":"24","author":"Lu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"nanoae2a3dbib85","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2023.103920","type":"journal-article","article-title":"Cancer stem cells in colorectal cancer: signaling pathways involved in stemness and therapy resistance","volume":"182","author":"Ebrahimi","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"nanoae2a3dbib86","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2023.106948","type":"journal-article","article-title":"Testosterone administration decreases sensitivity to angry facial expressions in healthy males: a computational modeling approach","volume":"161","author":"Nan","year":"2024","journal-title":"Psychoneuroendocrinology"},{"key":"nanoae2a3dbib87","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.sdentj.2022.05.004","type":"journal-article","article-title":"The effects of Lactobacillus reuteri on the inflammation and periodontal tissue repair in rats: a pilot study","volume":"34","author":"Garcia","year":"2022","journal-title":"Saudi Dent J."},{"key":"nanoae2a3dbib88","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v16.i2.100807","type":"journal-article","article-title":"Current and future perspectives in the management and treatment of colorectal cancer","volume":"16","author":"Romero-Zoghbi","year":"2025","journal-title":"World. J. Clin. Oncol."},{"key":"nanoae2a3dbib89","doi-asserted-by":"publisher","DOI":"10.1080\/10872981.2023.2295049","type":"journal-article","article-title":"The contextual interview: a cross-cutting patient-interviewing approach for social context","volume":"29","author":"Cahill","year":"2024","journal-title":"Med. Educ. Online"},{"key":"nanoae2a3dbib90","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.994847","type":"journal-article","article-title":"Endophytic Bacillus subtilis antagonize soil-borne fungal pathogens and suppress wilt complex disease in chickpea plants (Cicer arietinum L.)","volume":"13","author":"Mageshwaran","year":"2022","journal-title":"Front. Microbiol."},{"key":"nanoae2a3dbib91","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.3390\/e25091322","type":"journal-article","article-title":"On the emergence of the deviation from a Poisson law in stochastic mathematical models for radiation-induced DNA damage: a system size expansion","volume":"25","author":"Cordoni","year":"2023","journal-title":"Entropy"},{"key":"nanoae2a3dbib92","type":"journal-article","article-title":"Real-life application of the European Society for Medical Oncology guidelines for the prevention and treatment of cancer-associated thrombosis: challenges and perspectives","volume":"135","author":"Gerotziafas","year":"2025","journal-title":"Pol. Arch. Intern. Med."},{"key":"nanoae2a3dbib93","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41575-024-00934-z","type":"journal-article","article-title":"Mechanisms of metastatic colorectal cancer","volume":"21","author":"Ca\u00f1ellas-Socias","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"nanoae2a3dbib94","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.douler.2024.03.004","type":"journal-article","article-title":"Efficacy of chitosan mouthwash for oral mucositis: a promising therapeutic approach for head and neck cancer patients following radiotherapy","volume":"25","author":"Patil","year":"2024","journal-title":"Douleurs"},{"key":"nanoae2a3dbib95","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118014","type":"journal-article","article-title":"Combination therapy with immune checkpoint inhibitors in colorectal cancer: challenges, resistance mechanisms, and the role of microbiota","volume":"186","author":"Rahimi","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"nanoae2a3dbib96","first-page":"444","type":"journal-article","article-title":"Delivering prognostic news to older people with chronic disease: what format preference and level of involvement in decision making? A hospital survey","volume":"11","author":"Lewis","year":"2023","journal-title":"Healthcare"},{"key":"nanoae2a3dbib97","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2024.101341","type":"journal-article","article-title":"Anti-inflammatory response-based risk assessment in acute type A aortic dissection: a national multicenter cohort study","volume":"50","author":"Liu","year":"2024","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"nanoae2a3dbib98","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41586-023-05749-7","type":"journal-article","article-title":"Dehydration of a crystal hydrate at subglacial temperatures","volume":"616","author":"Eaby","year":"2023","journal-title":"Nature"},{"key":"nanoae2a3dbib99","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/ac7730","type":"journal-article","article-title":"Preparation of multi-function graphene materials through electrode-distance controlled electrochemical exfoliation","volume":"33","author":"Liang","year":"2022","journal-title":"Nanotechnology"},{"key":"nanoae2a3dbib100","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6407588","type":"journal-article","article-title":"The effect of citrus aurantium on non-small-cell lung cancer: a research based on network and experimental pharmacology","volume":"2023","author":"Yao","year":"2023","journal-title":"BioMed Res. Int."},{"key":"nanoae2a3dbib101","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/jpen.2549","type":"journal-article","article-title":"Adult patients with short bowel syndrome treated with teduglutide: a descriptive cohort study","volume":"47","author":"Daoud","year":"2023","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"nanoae2a3dbib102","first-page":"14","type":"journal-article","article-title":"Insights from the histopathologic analysis of acquired and genetic thoracic aortic aneurysms and dissections","volume":"51","author":"Buja","year":"2024","journal-title":"Tex. Heart Inst. J."},{"key":"nanoae2a3dbib103","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20230012","type":"journal-article","article-title":"Monitoring silica core@shell nanoparticle-bacterial film interactions using the multi-parametric surface Plasmon resonance technique","volume":"2","author":"Mustafa","year":"2023","journal-title":"Smart Med."},{"key":"nanoae2a3dbib104","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.3390\/molecules28041963","type":"journal-article","article-title":"Chitosan-based nanoparticles as effective drug delivery systems-a review","volume":"28","author":"Jafernik","year":"2023","journal-title":"Molecules"},{"key":"nanoae2a3dbib105","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s12088-024-01302-w","type":"journal-article","article-title":"Synthesis and biomedical based applications of selenium nanoparticles: a comprehensive review","volume":"65","author":"Raturi","year":"2025","journal-title":"Indian J. Microbiol."},{"key":"nanoae2a3dbib106","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.bmt.2023.12.001","type":"journal-article","article-title":"A review on selenium nanoparticles and their biomedical applications","volume":"6","author":"Karthik","year":"2024","journal-title":"Biomed. Technol."},{"key":"nanoae2a3dbib107","doi-asserted-by":"publisher","first-page":"3743","DOI":"10.1016\/j.apsb.2022.06.004","type":"journal-article","article-title":"Autophagy and beyond: unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications","volume":"12","author":"Zou","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"nanoae2a3dbib108","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jconrel.2023.01.003","type":"journal-article","article-title":"Smart delivery systems for microbial biofilm therapy: dissecting design, drug release and toxicological features","volume":"354","author":"Sousa","year":"2023","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib109","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2021.102173","type":"journal-article","article-title":"Capmatinib for patients with non-small cell lung cancer with MET exon 14 skipping mutations: a review of preclinical and clinical studies","volume":"95","author":"Wu","year":"2021","journal-title":"Cancer Treat. Rev."},{"key":"nanoae2a3dbib110","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155546","type":"journal-article","article-title":"Novel drug delivery systems in colorectal cancer: advances and future prospects","volume":"262","author":"Kamal","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"nanoae2a3dbib111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.107402","type":"journal-article","article-title":"Advances in targeted drug delivery systems for cancer treatment: current trends and future prospects","volume":"113","author":"Khan","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"nanoae2a3dbib112","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114312","type":"journal-article","article-title":"Considerations for personalized neoantigen vaccination in Malignant glioma","volume":"186","author":"Dunn","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"nanoae2a3dbib113","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1007\/s11095-021-03128-3","type":"journal-article","article-title":"RETRACTED ARTICLE: characterization of preclinical pharmacokinetic properties and prediction of human PK using a physiologically based pharmacokinetic model for a novel anti-arrhythmic agent sulcardine sulfate","volume":"38","author":"Ren","year":"2021","journal-title":"Pharm. Res."},{"key":"nanoae2a3dbib114","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/j.jconrel.2022.12.029","type":"journal-article","article-title":"Colonic drug delivery: formulating the next generation of colon-targeted therapeutics","volume":"353","author":"McCoubrey","year":"2023","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib115","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.jconrel.2023.02.005","type":"journal-article","article-title":"Comparison of HER2-targeted affibody conjugates loaded with auristatin- and maytansine-derived drugs","volume":"355","author":"Yin","year":"2023","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib116","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ejpb.2021.05.004","type":"journal-article","article-title":"Immune response with long-term memory triggered by amorphous aggregates of misfolded anti-EGFR VHH-7D12 is directed against the native VHH-7D12 as well as the framework of the analogous VHH-9G8","volume":"165","author":"Kibria","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"nanoae2a3dbib117","type":"journal-article","article-title":"Designing of pH-sensitive hydrogels for colon targeted drug delivery; characterization and in vitro evaluation","volume":"8","author":"Suhail","year":"2022","journal-title":"Gels"},{"key":"nanoae2a3dbib118","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s11095-021-03022-y","type":"journal-article","article-title":"Machine learning attempts for predicting human subcutaneous bioavailability of monoclonal antibodies","volume":"38","author":"Lou","year":"2021","journal-title":"Pharm. Res."},{"key":"nanoae2a3dbib119","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.jconrel.2023.03.002","type":"journal-article","article-title":"Protamine-mediated efficient transcellular and transmucosal delivery of proteins","volume":"356","author":"Wu","year":"2023","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib120","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ejpb.2022.01.007","type":"journal-article","article-title":"Mesenchymal stromal cells encapsulated in licensing hydrogels exert delocalized systemic protection against ulcerative colitis via subcutaneous xenotransplantation","volume":"172","author":"Gonzalez-Pujana","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"nanoae2a3dbib121","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.canlet.2021.01.005","type":"journal-article","article-title":"DIM-C-pPhtBu induces lysosomal dysfunction and unfolded protein response\u2014mediated cell death via excessive mitophagy","volume":"504","author":"Kang","year":"2021","journal-title":"Cancer Lett."},{"key":"nanoae2a3dbib122","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11095-021-03018-8","type":"journal-article","article-title":"Uptake pathway of apple-derived nanoparticle by intestinal cells to deliver its cargo","volume":"38","author":"Arai","year":"2021","journal-title":"Pharm. Res."},{"key":"nanoae2a3dbib123","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101963","type":"journal-article","article-title":"Advancing cancer therapy: nanomaterial-based encapsulation strategies for enhanced delivery and efficacy of curcumin","volume":"33","author":"Yan","year":"2025","journal-title":"Mater. Today Bio"},{"key":"nanoae2a3dbib124","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-03533-3","type":"journal-article","article-title":"Enhanced colon-targeted drug delivery through development of 5-fluorouracil-loaded cross-linked mastic gum nanoparticles","volume":"15","author":"Hani","year":"2025","journal-title":"Sci. Rep."},{"key":"nanoae2a3dbib125","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2025.104646","type":"journal-article","article-title":"Recent insights and applications of nanocarriers-based drug delivery systems for colonic drug delivery and cancer therapy: an updated review","volume":"208","author":"Noreen","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"nanoae2a3dbib126","first-page":"492","type":"journal-article","article-title":"Nanotechnology in drug delivery system: challenges and opportunities","volume":"12","author":"Prabhakar","year":"2020","journal-title":"J. Pharm. Sci. Res."},{"key":"nanoae2a3dbib127","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.2174\/0929867327666201005111722","type":"journal-article","article-title":"Nanocarrier-based drug delivery system for cancer therapeutics: a review of the last decade","volume":"28","author":"Sohail","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"nanoae2a3dbib128","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106259","type":"journal-article","article-title":"Functionalized FcRn-targeted nanosystems for oral drug delivery: a new approach to colorectal cancer treatment","volume":"176","author":"Hameedat","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"nanoae2a3dbib129","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jconrel.2021.05.042","type":"journal-article","article-title":"Magnetic nanoparticles for cancer theranostics: advances and prospects","volume":"335","author":"Li","year":"2021","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib130","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.canlet.2021.07.009","type":"journal-article","article-title":"lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL\/PTBP1 to facilitate SETD7\/LZTFL1 mRNA destabilization","volume":"520","author":"Wang","year":"2021","journal-title":"Cancer Lett."},{"key":"nanoae2a3dbib131","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41392-025-02280-1","type":"journal-article","article-title":"Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches","volume":"10","author":"Tufail","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"nanoae2a3dbib132","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s12951-022-01362-4","type":"journal-article","article-title":"Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3\/Periostin\/ERK signaling","volume":"20","author":"Zhao","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"nanoae2a3dbib133","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111823","type":"journal-article","article-title":"Exploring pH dependent delivery of 5-fluorouracil from functionalized multi-walled carbon nanotubes","volume":"205","author":"Solhjoo","year":"2021","journal-title":"Colloids Surf. B"},{"key":"nanoae2a3dbib134","first-page":"499","type":"book","article-title":"Polymeric nanoparticles-based drug delivery systems for anticancer therapy","author":"Solanki","year":"2023"},{"key":"nanoae2a3dbib135","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2022.100917","type":"journal-article","article-title":"Folate receptor as a biomarker and therapeutic target in solid tumors","volume":"47","author":"Young","year":"2023","journal-title":"Curr. Probl. Cancer"},{"key":"nanoae2a3dbib136","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.3390\/ijms23042180","type":"journal-article","article-title":"CD44 expression intensity marks colorectal cancer cell subpopulations with different extracellular vesicle release capacity","volume":"23","author":"Kelemen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"nanoae2a3dbib137","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.apsb.2019.10.002","type":"journal-article","article-title":"Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein","volume":"10","author":"Dong","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"nanoae2a3dbib138","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1186\/s12943-025-02435-2","type":"journal-article","article-title":"Advances in PLGA-based polymeric nanocarriers for colorectal cancer therapy: overcoming chemoresistance through controlled delivery strategies","volume":"24","author":"Khan","year":"2025","journal-title":"Mol. Cancer"},{"key":"nanoae2a3dbib139","doi-asserted-by":"publisher","first-page":"21125","DOI":"10.1021\/acsanm.5c03463","type":"journal-article","article-title":"Review of chitosan-coated nanoscale liposomes for enhanced drug delivery","volume":"8","author":"Alcantara","year":"2025","journal-title":"ACS Appl. Nano Mater."},{"key":"nanoae2a3dbib140","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1039\/D5NH00076A","type":"journal-article","article-title":"Exploring the intricacies of protein\u2013nanoparticle interaction and its implications in chronic diseases: a comprehensive review","volume":"10","author":"Samal","year":"2025","journal-title":"Nanoscale Horiz."},{"key":"nanoae2a3dbib141","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1039\/D5PM00095E","type":"journal-article","article-title":"Chitosan-based nano-objects for drug delivery: a review of their chemical modifications, supramolecular organization and biological fate","volume":"2","author":"Pereira Parchen","year":"2025","journal-title":"RSC Pharm."},{"key":"nanoae2a3dbib142","doi-asserted-by":"publisher","first-page":"9282","DOI":"10.1021\/acs.langmuir.5b01857","type":"journal-article","article-title":"Effects of ionic strength on the colloidal stability and interfacial assembly of hydrophobic ethyl cellulose nanoparticles","volume":"31","author":"Bizmark","year":"2015","journal-title":"Langmuir"},{"key":"nanoae2a3dbib143","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2024.104418","type":"journal-article","article-title":"Recent advances in the formation and identification of nanoparticle protein coronas and their effects on the digestion and absorption of polyphenols","volume":"146","author":"Zhang","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"nanoae2a3dbib144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2024.100040","type":"journal-article","article-title":"Chitosan nanoparticle delivery systems: an effective approach to enhancing efficacy and safety of anticancer drugs","volume":"3","author":"Grewal","year":"2024","journal-title":"Nano TransMed"},{"key":"nanoae2a3dbib145","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122935","type":"journal-article","article-title":"Chitosan nanoparticles of imatinib mesylate coated with TPGS for the treatment of colon cancer: in-vivo & in-vitro studies","volume":"348","author":"Bhirud","year":"2025","journal-title":"Carbohydrate Polym."},{"key":"nanoae2a3dbib146","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jconrel.2022.02.014","type":"journal-article","article-title":"Testing drug release from medicated contact lenses: the missing link to predict in vivo performance","volume":"343","author":"Pereira-da-mota","year":"2022","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib147","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.ijbiomac.2021.05.081","type":"journal-article","article-title":"Effect of combination of dry heating and glucose addition on pasting and gelling behavior of starches","volume":"183","author":"Lee","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib148","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119473","type":"journal-article","article-title":"Mechanically tunable ion-crosslinked alginate-based gradient hydrogels by electrolysis-electrophoresis method","volume":"289","author":"Xia","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"nanoae2a3dbib149","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1039\/D4SM01222D","type":"journal-article","article-title":"Advanced polymeric systems for colon drug delivery: from experimental models to market applications","volume":"21","author":"Crispino","year":"2025","journal-title":"Soft Matter"},{"key":"nanoae2a3dbib150","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113957","type":"journal-article","article-title":"Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: inserts, patches, wafers, and implants","volume":"177","author":"Abdelkader","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"nanoae2a3dbib151","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s00604-022-05494-0","type":"journal-article","article-title":"Aptamer-AuNP-conjugated carboxymethyl chitosan\u2013functionalized graphene oxide for colorimetric identification of Salmonella typhimurium","volume":"189","author":"Wu","year":"2022","journal-title":"Mikrochim. Acta"},{"key":"nanoae2a3dbib152","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102487","type":"journal-article","article-title":"Nanotechnology based drug delivery system: current strategies and emerging therapeutic potential for medical science","volume":"63","author":"Sahu","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"nanoae2a3dbib153","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106414","type":"journal-article","article-title":"Development of targeted lipid nanoparticles for the combined therapy of triple negative breast cancer: can curcumin and 6-aminoflavone promote doxorubicin in vitro efficacy?","volume":"102","author":"Peira","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"nanoae2a3dbib154","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.2217\/nnm-2022-0023","type":"journal-article","article-title":"Recent advances in mesoporous silica nanoparticle-based targeted drug-delivery systems for cancer therapy","volume":"17","author":"Li","year":"2022","journal-title":"Nanomedicine"},{"key":"nanoae2a3dbib155","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2174206","type":"journal-article","article-title":"Recent progress in nanotechnology-based drug carriers for resveratrol delivery","volume":"30","author":"Li","year":"2023","journal-title":"Drug Deliv."},{"key":"nanoae2a3dbib156","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21227","type":"journal-article","article-title":"Nanoparticle-based materials in anticancer drug delivery: current and future prospects","volume":"9","author":"Ajith","year":"2023","journal-title":"Heliyon"},{"key":"nanoae2a3dbib157","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105915","type":"journal-article","article-title":"Development of gliclazide ionic liquid and the transdermal patches: an effective and noninvasive sustained release formulation to achieve hypoglycemic effects","volume":"164","author":"Zhou","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"nanoae2a3dbib158","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112447","type":"journal-article","article-title":"Penicillin-binding proteins (PBPs) determine antibiotic action in Langmuir monolayers as nanoarchitectonics mimetic membranes of methicillin-resistant Staphylococcus aureus","volume":"214","author":"Martins","year":"2022","journal-title":"Colloids Surf. B"},{"key":"nanoae2a3dbib159","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117878","type":"journal-article","article-title":"Mussel-inspired adhesive and polypeptide-based antibacterial thermo-sensitive hydroxybutyl chitosan hydrogel as BMSCs 3D culture matrix for wound healing","volume":"261","author":"Tian","year":"2021","journal-title":"Carbohydrate Polym."},{"key":"nanoae2a3dbib160","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.3390\/pharmaceutics14122762","type":"journal-article","article-title":"Time-based formulation strategies for colon drug delivery","volume":"14","author":"Gazzaniga","year":"2022","journal-title":"Pharmaceutics"},{"key":"nanoae2a3dbib161","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ijbiomac.2022.09.196","type":"journal-article","article-title":"Folate decorated lipid chitosan hybrid nanoparticles of 5-fluorouracil for enhanced anticancer efficacy against colon cancer","volume":"222","author":"Khan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib162","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127142","type":"journal-article","article-title":"Folic acid-chitosan functionalized polymeric nanocarriers to treat colon cancer","volume":"253","author":"Bhaskaran","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib163","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.108192","type":"journal-article","article-title":"Copper carbonate nanoparticles as an effective biomineralized carrier to load macromolecular drugs for multimodal therapy","volume":"34","author":"Dong","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"nanoae2a3dbib164","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.2147\/IJN.S257700","type":"journal-article","article-title":"Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer","volume":"15","author":"Entezar-Almahdi","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"nanoae2a3dbib165","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119327","type":"journal-article","article-title":"Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways","volume":"287","author":"Zhong","year":"2022","journal-title":"Carbohydrate Polym."},{"key":"nanoae2a3dbib166","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142486","type":"journal-article","article-title":"Hyaluronic acid-functionalized nanomedicines for CD44-receptors-mediated targeted cancer therapy: a review of selective targetability and biodistribution to tumor microenvironment","volume":"308","author":"Al Jayoush","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib167","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102151","type":"journal-article","article-title":"pH-responsive magnetic Fe3O4 modified chitosan nanoparticles loaded with \u03b2-acids to improve colorectal cancer treatment","volume":"34","author":"Guo","year":"2025","journal-title":"Mater. Today Bio"},{"key":"nanoae2a3dbib168","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112676","type":"journal-article","article-title":"Multifunctional active ingredient-based delivery systems for skincare formulations: a review","volume":"217","author":"Kouassi","year":"2022","journal-title":"Colloids Surf. B"},{"key":"nanoae2a3dbib169","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/ptr.8394","type":"journal-article","article-title":"Smart polymer-based delivery systems for curcumin in colon cancer therapy: a review","volume":"39","author":"Kamath","year":"2025","journal-title":"Phytother. Res."},{"key":"nanoae2a3dbib170","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2025.102785","type":"journal-article","article-title":"Sustainable methods for the synthesis of chiral nanomaterials","volume":"6","author":"Hong","year":"2025","journal-title":"Cell Rep. Phys. Sci."},{"key":"nanoae2a3dbib171","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3390\/inorganics13100337","type":"journal-article","article-title":"Smart inorganic nanomaterials for tumor microenvironment modulation","volume":"13","author":"Jiang","year":"2025","journal-title":"Inorganics"},{"key":"nanoae2a3dbib172","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.jconrel.2022.07.018","type":"journal-article","article-title":"Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment","volume":"349","author":"Hailing","year":"2022","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib173","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s12032-025-02910-2","type":"journal-article","article-title":"Advances in nanotechnology for colorectal cancer: a smart targeting and theranostics approach","volume":"42","author":"Sahoo","year":"2025","journal-title":"Med. Oncol."},{"key":"nanoae2a3dbib174","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejpb.2022.08.004","type":"journal-article","article-title":"Biodistribution and toxicity of innate defense regulator 1018 (IDR-1018)","volume":"179","author":"Esposito","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"nanoae2a3dbib175","first-page":"2024","type":"journal-article","article-title":"Nanosponge drug delivery systems: advances, applications, and challenges introduction","volume":"23","author":"Srivastava","year":"2024","journal-title":"YMER Digit."},{"key":"nanoae2a3dbib176","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23303","type":"journal-article","article-title":"Nanosponge: a promising and intriguing strategy in medical and pharmaceutical Science","volume":"10","author":"Garg","year":"2024","journal-title":"Heliyon"},{"key":"nanoae2a3dbib177","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106249","type":"journal-article","article-title":"Peptide-based targeted cancer therapeutics: design, synthesis and biological evaluation","volume":"176","author":"Iwanov","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"nanoae2a3dbib178","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114771","type":"journal-article","article-title":"Mechanobiology of cancer cell responsiveness to chemotherapy and immunotherapy: mechanistic insights and biomaterial platforms","volume":"196","author":"Shakiba","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"nanoae2a3dbib179","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ijbiomac.2022.05.103","type":"journal-article","article-title":"Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: preparation, characterization, and adsorption mechanism","volume":"213","author":"Zeng","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib180","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113427","type":"journal-article","article-title":"Oxygen vacancy engineering of TiO2 nanosheets for enhanced photothermal therapy against cervical cancer in the second near-infrared window","volume":"229","author":"Bian","year":"2023","journal-title":"Biointerfaces"},{"key":"nanoae2a3dbib181","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2022.100116","type":"journal-article","article-title":"In vitro anticancer activity of curcumin loaded chitosan nanoparticles (CLCNPs) against Vero cells","volume":"3","author":"Deepika","year":"2022","journal-title":"Pharmacol. Res.\u2014Mod. Chin. Med."},{"key":"nanoae2a3dbib182","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113278","type":"journal-article","article-title":"Effective drug combinations of betulinic acid and ceranib-2 loaded Zn:MnO2 doped-polymeric nanocarriers against PC-3 prostate cancer cells","volume":"225","author":"Tan","year":"2023","journal-title":"Colloids Surf. B"},{"key":"nanoae2a3dbib183","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119276","type":"journal-article","article-title":"Molecular dynamic simulation: study on the recognition mechanism of linear \u03b2-(1 \u2192 3)-D-glucan by Dectin-1","volume":"286","author":"Feng","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"nanoae2a3dbib184","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.3390\/molecules29133098","type":"journal-article","article-title":"Vanillic acid nanocomposite: synthesis, characterization analysis, antimicrobial, and anticancer potentials","volume":"29","author":"Venkidasamy","year":"2024","journal-title":"Molecules"},{"key":"nanoae2a3dbib185","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s12906-021-03362-7","type":"journal-article","article-title":"Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers","volume":"21","author":"Alipanah","year":"2021","journal-title":"BMC Complement. Med. Ther."},{"key":"nanoae2a3dbib186","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121606","type":"journal-article","article-title":"Formulation of rifampicin softpellets for high dose delivery to the lungs with a novel high dose dry powder inhaler","volume":"617","author":"Etschmann","year":"2022","journal-title":"Int. J. Pharm."},{"key":"nanoae2a3dbib187","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118464","type":"journal-article","article-title":"Chitosan-based nanodelivery systems for cancer therapy: recent advances","volume":"272","author":"Narmani","year":"2021","journal-title":"Carbohydrate Polym."},{"key":"nanoae2a3dbib188","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112468","type":"journal-article","article-title":"Carbonized lotus leaf\/ZnO\/Au for enhanced synergistic mechanical and photocatalytic bactericidal activity under visible light irradiation","volume":"215","author":"Xu","year":"2022","journal-title":"Colloids Surf. B"},{"key":"nanoae2a3dbib189","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.jconrel.2024.02.018","type":"journal-article","article-title":"Lipopolymer mediated siRNA delivery targeting aberrant oncogenes for effective therapy of myeloid leukemia in preclinical animal models","volume":"367","author":"Ansari","year":"2024","journal-title":"J. Control. Release"},{"key":"nanoae2a3dbib190","doi-asserted-by":"publisher","first-page":"974","DOI":"10.3390\/pharmaceutics12100974","type":"journal-article","article-title":"Deep tumor penetration of doxorubicin-loaded glycol chitosan nanoparticles using high-intensity focused ultrasound","volume":"12","author":"Choi","year":"2020","journal-title":"Pharmaceutics"},{"key":"nanoae2a3dbib191","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ijbiomac.2022.03.065","type":"journal-article","article-title":"Potential for non-starch polysaccharides in the prevention and remediation of cognitive impairment: a comprehensive review","volume":"208","author":"Rang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"nanoae2a3dbib192","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.matpr.2023.01.142","type":"journal-article","article-title":"Environmental gas sensing studies using flower-like MoS2 hybrid structure","volume":"83","author":"Rawat","year":"2023","journal-title":"Mater. Today: Proc."},{"key":"nanoae2a3dbib193","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117768","type":"journal-article","article-title":"Chitosan hydrogels in 3D printing for biomedical applications","volume":"260","author":"Rajabi","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"nanoae2a3dbib194","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121624","type":"journal-article","article-title":"Raman-based real-time dissolution prediction using a deterministic permeation model","volume":"617","author":"Horkovics-Kovats","year":"2022","journal-title":"Int. J. Pharm."},{"key":"nanoae2a3dbib195","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111210","type":"journal-article","article-title":"An injectable high-conductive bimaterial scaffold for neural stimulation","volume":"195","author":"Wang","year":"2020","journal-title":"Colloids Surf. B"},{"key":"nanoae2a3dbib196","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111671","type":"journal-article","article-title":"Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis","volume":"120","author":"Zhang","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"nanoae2a3dbib197","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.800481","type":"journal-article","article-title":"CD44-targeted nanocarrier for cancer therapy","volume":"12","author":"Kesharwani","year":"2021","journal-title":"Front. Pharmacol."},{"key":"nanoae2a3dbib198","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ejpb.2020.01.003","type":"journal-article","article-title":"Collagenase loaded chitosan nanoparticles for digestion of the collagenous scar in liver fibrosis: the effect of chitosan intrinsic collagen binding on the success of targeting","volume":"148","author":"El-Safy","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"nanoae2a3dbib199","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117580","type":"journal-article","article-title":"Facile synthesis of self-healing and layered sodium alginate\/polyacrylamide hydrogel promoted by dynamic hydrogen bond","volume":"256","author":"Zhao","year":"2021","journal-title":"Carbohydrate Polym."}],"container-title":["Nanotechnology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:07:25Z","timestamp":1766048845000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae2a3d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":200,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12,18]]},"published-print":{"date-parts":[[2026,1,9]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6528\/ae2a3d","relation":{},"ISSN":["0957-4484","1361-6528"],"issn-type":[{"value":"0957-4484","type":"print"},{"value":"1361-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"Precision nanoscale engineering of chitosan nanoparticles via ionic gelation, eco-friendly synthesis, and ligand functionalization for improved targeted drug delivery in colon cancer treatment","name":"article_title","label":"Article Title"},{"value":"Nanotechnology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2025 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-09-07","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-12-09","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-12-18","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}