{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:54:19Z","timestamp":1781704459779,"version":"3.54.5"},"reference-count":25,"publisher":"IOP Publishing","issue":"24","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751654"],"award-info":[{"award-number":["2024M751654"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32501239"],"award-info":[{"award-number":["32501239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2026,6,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The targeted delivery of therapeutic agents to lymphoid tissues or immune cells plays an important role in tumor vaccine efficacy. To investigate size-dependent immunological effects, we designed luminescent nanoparticles (NPs) with three distinct sizes (RSNP-30, RSNP-150, and RSNP-600) and systematically evaluated their efficiency in lymphatic retention, antigen-presenting cell uptake, and\n                    <jats:italic>in vivo<\/jats:italic>\n                    vaccine performance using 4T1-tumor bearing mice. Our findings revealed that larger NPs (RSNP-150 and RSNP-600) exhibited enhanced lymphatic accumulation 24 h post-administration and were more efficiently internalized by bone marrow-derived dendritic cells and Raw 264.7 macrophages\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Notably, tumor inhibition efficacy correlated positively with increasing NP size (within the size range of 30\u2013600 nm), demonstrating the advantages of submicron-scale vaccine delivery systems. Therefore, these results provide valuable insights for the design of nano-sized delivery systems for enhanced immunotherapeutic outcomes.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/ae78e1","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:47:49Z","timestamp":1780699669000},"page":"245101","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Submicron-sized nano-vaccines enhance lymphatic retention and antigen-presenting cell uptake"],"prefix":"10.1088","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-5370","authenticated-orcid":true,"given":"Jingsong","family":"Lu","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering, Zhejiang University of Technology"},{"name":"Research Center of Magnetic and Electronic Materials, Zhejiang University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Tsinghua University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-8979","authenticated-orcid":true,"given":"Zhenhu","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-02-23","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-06-05","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-06-17","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}