{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:19:25Z","timestamp":1783952365003,"version":"3.55.0"},"reference-count":49,"publisher":"IOP Publishing","issue":"25","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"name":"Doctoral Start-up Fund Project of Affiliated Hospital of Guizhou Medical University","award":["gyfybsky-2024-47"],"award-info":[{"award-number":["gyfybsky-2024-47"]}]},{"name":"The Youth Guidance Project of the Basic Research Program of the Science and Technology Department of Guizhou Province","award":["Qiankehe Foundation QN [2025]127"],"award-info":[{"award-number":["Qiankehe Foundation QN [2025]127"]}]},{"name":"National Natural Science Foundation of Regional Fund Cultivation Program Project of the Affiliated Hospital of Guizhou Medical University","award":["gyfynsfc [2023]-65"],"award-info":[{"award-number":["gyfynsfc [2023]-65"]}]},{"name":"Guizhou Provincial Health Commission Science and Technology Fund","award":["gzwkj2026-132"],"award-info":[{"award-number":["gzwkj2026-132"]}]},{"name":"Guizhou Provincial Science and Technology Projects","award":["ZK [2023] Key Project 041"],"award-info":[{"award-number":["ZK [2023] Key Project 041"]}]},{"name":"Guizhou Provincial Science and Technology Programme Project","award":["Qiankeheji-ZK[2024] General 204"],"award-info":[{"award-number":["Qiankeheji-ZK[2024] General 204"]}]},{"name":"The 2025 Research and Education Project and Research Feedback Teaching Project of the Affiliated Hospital of Guizhou Medical University","award":["gyfykj-2025-y17"],"award-info":[{"award-number":["gyfykj-2025-y17"]}]},{"name":"Supported by Guizhou Provincial Science and Technology Projects","award":["ZK[2023]369"],"award-info":[{"award-number":["ZK[2023]369"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2026,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Breast cancer continues to be the most common cancer affecting women globally, with triple-negative breast cancer (TNBC) emerging as a particularly challenging subtype due to its high invasiveness and unfavorable prognosis. While chemotherapy remains the standard treatment for TNBC, patients often face significant side effects and the potential for drug resistance, which can complicate treatment outcomes. In this study, we focused on the\n                    <jats:italic>in vitro<\/jats:italic>\n                    evaluation of a novel nanotherapeutic strategy for TNBC. Epigallocatechin gallate (EGCG), a major catechin derived from green tea, has demonstrated anti-cancer potential, but its clinical application is hindered by low bioavailability and instability. To address these limitations, we developed self-assembled nanoparticles composed of EGCG and tannic acid (TA), stabilized by appropriate excipients, to form EGCG-TA nanoparticles (ET-NPs). The rationale for combining EGCG with TA is based on their complementary polyphenolic structures and potential synergistic anti-tumor mechanisms, as supported by combination index (CI) and IC\n                    <jats:sub>50<\/jats:sub>\n                    data. Characterization of these nanoparticles demonstrated their favorable physicochemical properties, including optimal particle size, zeta potential, and stability.\n                    <jats:italic>In vitro<\/jats:italic>\n                    studies showed that ET-NPs exhibited improved serum stability and significantly greater inhibition of TNBC cells proliferation compared to free EGCG or TA. The observed anti-tumor effect is linked to a significant reduction in mitochondrial membrane potential and increased intracellular reactive oxygen species levels, ultimately resulting in mitochondrial damage and cell death. Additionally, Fourier transform infrared spectroscopy analysis confirmed the successful assembly of EGCG and TA through non-covalent interactions. By improving the stability and anti-tumor properties of EGCG, the self-assembled ET-NPs represent a promising new approach for the\n                    <jats:italic>in vitro<\/jats:italic>\n                    treatment of TNBC, providing a foundation for future\n                    <jats:italic>in vivo<\/jats:italic>\n                    and translational studies.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/ae7a7d","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:48:34Z","timestamp":1781045314000},"page":"255601","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Self-assembled nanoparticles of epigallocatechin gallate and tannic acid against triple-negative breast cancer via mediating mitochondrial damage"],"prefix":"10.1088","volume":"37","author":[{"given":"Chan","family":"Liu","sequence":"first","affiliation":[{"name":"Clinical Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Guizhou Medical University"},{"name":"Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhe","family":"Zhao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongkai","family":"Chen","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Guo","sequence":"additional","affiliation":[{"name":"Clinical Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Guizhou Medical University"},{"name":"Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengli","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Guizhou Medical University"},{"name":"Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenpeng","family":"Niu","sequence":"additional","affiliation":[{"name":"Clinical Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Guizhou Medical University"},{"name":"Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Pan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Xie","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Guizhou Medical University"},{"name":"Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4149-6828","authenticated-orcid":true,"given":"Xiangping","family":"Lin","sequence":"additional","affiliation":[{"name":"Clinical Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Guizhou Medical University"},{"name":"Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"nanoae7a7dbib1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","type":"journal-article","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"nanoae7a7dbib2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","type":"journal-article","article-title":"Cancer statistics","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"nanoae7a7dbib3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","type":"journal-article","article-title":"Cancer statistics","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"nanoae7a7dbib4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","type":"journal-article","article-title":"Cancer statistics","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"nanoae7a7dbib5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-071674","type":"journal-article","article-title":"Advances in systemic therapies for triple negative breast cancer","volume":"381","author":"Leon-ferre","year":"2023","journal-title":"BMJ"},{"key":"nanoae7a7dbib6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.21037\/tbcr-24-28","type":"journal-article","article-title":"Targeting low-risk triple-negative breast cancer: a review on de-escalation strategies for a new era","volume":"6","author":"Carvalho","year":"2025","journal-title":"Transl. Breast Cancer Res."},{"key":"nanoae7a7dbib7","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s13346-018-0551-3","type":"journal-article","article-title":"Metastatic and triple-negative breast cancer: challenges and treatment options","volume":"8","author":"Al-mahmood","year":"2018","journal-title":"Drug Deliv. Transl. Res."},{"key":"nanoae7a7dbib8","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00262-020-02736-z","type":"journal-article","article-title":"Pembrolizumab and atezolizumab in triple-negative breast cancer","volume":"70","author":"Kwapisz","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"key":"nanoae7a7dbib9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12951-020-00758-4","type":"journal-article","article-title":"Development of targeted therapy therapeutics to sensitize triple-negative breast cancer chemosensitivity utilizing bacteriophage phi29 derived packaging RNA","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"nanoae7a7dbib10","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.1021\/acsbiomaterials.4c00108","type":"journal-article","article-title":"Nanoparticle-mediated immunotherapy in triple-negative breast cancer","volume":"10","author":"Wang","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"nanoae7a7dbib11","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3969\/j.issn.1674-4136.2024.05.0004","type":"journal-article","article-title":"Advances in precision therapy for triple-negative breast cancer","volume":"16","author":"Guo","year":"2024","journal-title":"Chin. J. Oncol. Surg."},{"key":"nanoae7a7dbib12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.106059","type":"journal-article","article-title":"Reversing adenosine-mediated immunosuppression in triple-negative breast cancer by synergistic chemo-immunotherapy via stimuli-responsive nanomedicines","volume":"123","author":"Cheng","year":"2026","journal-title":"eBioMedicine"},{"key":"nanoae7a7dbib13","doi-asserted-by":"publisher","first-page":"7607","DOI":"10.7150\/thno.116250","type":"journal-article","article-title":"Metabolic targeting of oxidative phosphorylation enhances chemosensitivity in triple-negative breast cancer via a synergistic nanomedicine","volume":"15","author":"Shen","year":"2025","journal-title":"Theranostics"},{"key":"nanoae7a7dbib14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/annonc\/mdy517","type":"journal-article","article-title":"Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort a of the phase II KEYNOTE-086 study","volume":"30","author":"Adams","year":"2019","journal-title":"Ann. Oncol."},{"key":"nanoae7a7dbib15","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1200\/JCO.2015.64.8931","type":"journal-article","article-title":"Pembrolizumab in patients with advanced triple-negative breast cancer: phase ib KEYNOTE-012 study","volume":"34","author":"Nanda","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"nanoae7a7dbib16","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1056\/NEJMoa1814213","type":"journal-article","article-title":"Sacituzumab govitecan-hziy in refractory metastatic triple-negative breast cancer","volume":"380","author":"Bardia","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"nanoae7a7dbib17","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1200\/JCO.2016.70.8297","type":"journal-article","article-title":"Efficacy and safety of anti-trop-2 antibody drug conjugate sacituzumab govitecan (IMMU-132) in heavily pretreated patients with metastatic triple-negative breast cancer","volume":"35","author":"Bardia","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"nanoae7a7dbib18","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1056\/NEJMoa1706450","type":"journal-article","article-title":"Olaparib for metastatic breast cancer in patients with a germline BRCA mutation","volume":"377","author":"Robson","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"nanoae7a7dbib19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2147\/BCTT.S69488","type":"journal-article","article-title":"Triple-negative breast cancer: treatment challenges and solutions","volume":"8","author":"Jerusalem","year":"2016","journal-title":"Breast Cancer Targets Ther."},{"key":"nanoae7a7dbib20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13058-020-01296-5","type":"journal-article","article-title":"Triple-negative breast cancer molecular subtyping and treatment progress","volume":"22","author":"Yin","year":"2020","journal-title":"Breast Cancer Res."},{"key":"nanoae7a7dbib21","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13045-022-01341-0","type":"journal-article","article-title":"Recent advances in therapeutic strategies for triple-negative breast cancer","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"nanoae7a7dbib22","doi-asserted-by":"publisher","first-page":"6779","DOI":"10.1158\/1538-7445.AM2025-6779","type":"journal-article","article-title":"Abstract 6779: the plant derived compound simalikalactone D is a potent anticancer agent in triple negative breast cancer cells","volume":"85","author":"Nieves","year":"2025","journal-title":"Cancer Res."},{"key":"nanoae7a7dbib23","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157304","type":"journal-article","article-title":"The chemosensitizing activity of betulinic acid in suppressing macrophage polarization through GSK-3\u03b2\/\u03b2-catenin\/CXCL1 signaling in breast cancer","volume":"148","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"nanoae7a7dbib24","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.3390\/molecules25143146","type":"journal-article","article-title":"Potential therapeutic targets of epigallocatechin gallate (EGCG), the most abundant catechin in green tea, and its role in the therapy of various types of cancer","volume":"25","author":"Almatroodi","year":"2020","journal-title":"Molecules"},{"key":"nanoae7a7dbib25","doi-asserted-by":"publisher","first-page":"6075","DOI":"10.3390\/ijms23116075","type":"journal-article","article-title":"The potential of epigallocatechin gallate (EGCG) in targeting autophagy for cancer treatment: a narrative review","volume":"23","author":"Ferrari","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"nanoae7a7dbib26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.tifs.2019.09.017","type":"journal-article","article-title":"The effects and mechanisms of epigallocatechin-3-gallate on reversing multidrug resistance in cancer","volume":"93","author":"Zhang","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"nanoae7a7dbib27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810244","type":"journal-article","article-title":"Combination therapy using polyphenols: an efficient way to improve antitumoral activity and reduce resistance","volume":"23","author":"Vladu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"nanoae7a7dbib28","doi-asserted-by":"publisher","first-page":"689","DOI":"10.2174\/1568009621666210525152802","type":"journal-article","article-title":"New insights toward nanostructured drug delivery of plant-derived polyphenol compounds: cancer treatment and gene expression profiles","volume":"21","author":"Khazei","year":"2021","journal-title":"Curr. Cancer Drug Targets"},{"key":"nanoae7a7dbib29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jcis.2021.07.015","type":"journal-article","article-title":"Tannic acid: a green and efficient stabilizer of Au, Ag, Cu and Pd nanoparticles for the 4-Nitrophenol Reduction, Suzuki\u2013Miyaura coupling reactions and click reactions in aqueous solution","volume":"604","author":"Liu","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"nanoae7a7dbib30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113561","type":"journal-article","article-title":"Pharmacological effects and mechanisms of tannic acid","volume":"154","author":"Jing","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"nanoae7a7dbib31","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.1039\/D1TB00383F","type":"journal-article","article-title":"Tannic acid-based metal phenolic networks for bio-applications: a review","volume":"9","author":"Guo","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"nanoae7a7dbib32","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202305563","type":"journal-article","article-title":"Tannic acid-based nanomaterials for tolerogenic immunotherapy of rheumatoid arthritis","volume":"33","author":"Wu","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"nanoae7a7dbib33","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3390\/nu8080515","type":"journal-article","article-title":"Natural polyphenols for prevention and treatment of cancer","volume":"8","author":"Zhou","year":"2016","journal-title":"Nutrients"},{"key":"nanoae7a7dbib34","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1039\/C9BM01646E","type":"journal-article","article-title":"A multi-functional drug delivery system based on polyphenols for efficient tumor inhibition and metastasis prevention","volume":"8","author":"Chen","year":"2020","journal-title":"Biomater. Sci."},{"key":"nanoae7a7dbib35","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105894","type":"journal-article","article-title":"Engineered EGCG-containing biomimetic nanoassemblies as effective delivery platform for enhanced cancer therapy","volume":"9","author":"Wu","year":"2022","journal-title":"Adv. Sci."},{"key":"nanoae7a7dbib36","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2144\/000113610","type":"journal-article","article-title":"Mitochondrial membrane potential probes and the proton gradient: a practical usage guide","volume":"50","author":"Perry","year":"2011","journal-title":"BioTechniques"},{"key":"nanoae7a7dbib37","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","type":"journal-article","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"nanoae7a7dbib38","doi-asserted-by":"publisher","first-page":"e3759","DOI":"10.7717\/peerj.3759","type":"journal-article","article-title":"Laboratory evaluation of different formulations of stress coat\u00ae for slime production in goldfish (carassius auratus) and koi (cyprinus carpio)","volume":"5","author":"Shivappa","year":"2017","journal-title":"PeerJ"},{"key":"nanoae7a7dbib39","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1080\/10717544.2020.1785582","type":"journal-article","article-title":"Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on soluplus\u00ae-poloxamer 188","volume":"27","author":"Li","year":"2020","journal-title":"Drug Deliv."},{"key":"nanoae7a7dbib40","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.nano.2009.05.004","type":"journal-article","article-title":"The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity","volume":"6","author":"Yan","year":"2010","journal-title":"Nanomedicine"},{"key":"nanoae7a7dbib41","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22691","type":"journal-article","article-title":"Optimization of cationic nanoparticles stabilized by poloxamer 188: a potential approach for improving the biological activity of aloeperryi","volume":"9","author":"Aldayel","year":"2023","journal-title":"Heliyon"},{"key":"nanoae7a7dbib42","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.apsb.2021.08.016","type":"journal-article","article-title":"Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation","volume":"12","author":"Chen","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"nanoae7a7dbib43","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2017.34","type":"journal-article","article-title":"Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity","volume":"3","author":"Wang","year":"2017","journal-title":"Cell Death Discov."},{"key":"nanoae7a7dbib44","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.jnutbio.2015.07.001","type":"journal-article","article-title":"Effects of EGCG content in green tea extract on pharmacokinetics, oxidative status and expression of inflammatory and apoptotic genes in the rat ocular tissues","volume":"26","author":"Chu","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"nanoae7a7dbib45","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3390\/molecules26030574","type":"journal-article","article-title":"Phytochemical analysis and in vitro effects of allium fistulosum L. and allium sativum L. extracts on human normal and tumor cell lines: a comparative study","volume":"26","author":"\u0162igu","year":"2021","journal-title":"Molecules"},{"key":"nanoae7a7dbib46","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.1021\/acsami.0c20268","type":"journal-article","article-title":"Tumor microenvironment-responsive nanococktails for synergistic enhancement of cancer treatment via cascade reactions","volume":"13","author":"Chen","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"nanoae7a7dbib47","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.jconrel.2020.08.066","type":"journal-article","article-title":"Inhibition of growth and lung metastasis of breast cancer by tumor-homing triple-bioresponsive nanotherapeutics","volume":"328","author":"Zhang","year":"2020","journal-title":"J. Control. Release"},{"key":"nanoae7a7dbib48","doi-asserted-by":"publisher","first-page":"10382","DOI":"10.1080\/10408398.2022.2068500","type":"journal-article","article-title":"Chemico-biological aspects of (-)- epigallocatechin- 3 -gallate (EGCG) to improve its stability, bioavailability and membrane permeability: current status and future prospects","volume":"63","author":"Sahadevan","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"nanoae7a7dbib49","doi-asserted-by":"publisher","first-page":"9932","DOI":"10.1039\/D1TB01899J","type":"journal-article","article-title":"Design and construction of IR780- and EGCG-based and mitochondrial targeting nanoparticles and their application in tumor chemo-phototherapy","volume":"9","author":"Bao","year":"2021","journal-title":"J. Mater. Chem. B"}],"container-title":["Nanotechnology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:24:49Z","timestamp":1783949089000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6528\/ae7a7d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":49,"journal-issue":{"issue":"25","published-online":{"date-parts":[[2026,6,19]]},"published-print":{"date-parts":[[2026,6,26]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6528\/ae7a7d","relation":{},"ISSN":["0957-4484","1361-6528"],"issn-type":[{"value":"0957-4484","type":"print"},{"value":"1361-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"Self-assembled nanoparticles of epigallocatechin gallate and tannic acid against triple-negative breast cancer via mediating mitochondrial damage","name":"article_title","label":"Article Title"},{"value":"Nanotechnology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-02-26","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-06-09","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-06-19","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}