{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:01:11Z","timestamp":1792785671011,"version":"4.5.0"},"reference-count":158,"publisher":"IOP Publishing","issue":"41","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"National Institute of Biomedical Imaging and Bioengineering Grant","award":["R00EB028325"],"award-info":[{"award-number":["R00EB028325"]}],"id":[{"id":"https:\/\/ror.org\/00372qc85","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Science Foundation","award":["CHE-2304955"],"award-info":[{"award-number":["CHE-2304955"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Nanotechnology"],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The ability to conduct nanoscale imaging and\n                    <jats:italic>in situ<\/jats:italic>\n                    chemical analysis in liquid environments can greatly benefit biological and soft materials research. Scanning ion-conductance microscopy (SICM) is one of the most popular non-contact techniques for imaging and manipulating living cells and soft substrates in their native environments, using ionic current feedback to enable gentle and precise mapping. On the other hand, tip-enhanced Raman scattering (TERS) has achieved label-free, molecularly specific nanoscale characterization via plasmonic enhancement provided by the probe tip. Recent developments in both techniques have made it possible to combine SICM with TERS. The resulting hybrid SICM-TERS can enable simultaneous, correlated mapping of topography in liquid environments. This review provides an overview of SICM and TERS leading up to the development of SICM-TERS, including their respective principles, instrumental developments, and current state of the art. Additionally, it discusses how combining these two techniques enables new opportunities for real-time, minimally invasive investigations of dynamic biological processes and complex interfacial phenomena under native conditions. As probe durability and multimodal microscopy integration improve, SICM-TERS is expected to take a more versatile role in correlative nanoscale imaging in the future. This will have a major impact on nanomedicine, biology, and materials research.\n                  <\/jats:p>","DOI":"10.1088\/1361-6528\/aea337","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:48:28Z","timestamp":1788821308000},"page":"412001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of scanning ion-conductance microscopy based tip-enhanced Raman spectroscopy in liquid environments"],"prefix":"10.1088","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-7610","authenticated-orcid":true,"given":"Abu Montakim","family":"Tareq","sequence":"first","affiliation":[{"name":"University of Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4193-0542","authenticated-orcid":true,"given":"Richard Ifeanyichukwu","family":"Ikwugbado","sequence":"additional","affiliation":[{"name":"University of Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8955-0263","authenticated-orcid":true,"given":"Oluwaferanmi","family":"Isinkaye","sequence":"additional","affiliation":[{"name":"University of Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3782-6546","authenticated-orcid":true,"given":"Naihao","family":"Chiang","sequence":"additional","affiliation":[{"name":"University of Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"nanoaea337bib1","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1126\/science.1130279","type":"journal-article","article-title":"Phase separation of lipid membranes analyzed with high-resolution secondary ion mass spectrometry","volume":"313","author":"Kraft","year":"2006","journal-title":"Science"},{"key":"nanoaea337bib2","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/jrs.2387","type":"journal-article","article-title":"Performing tip-enhanced Raman spectroscopy in liquids","volume":"40","author":"Schmid","year":"2009","journal-title":"J. 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