{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:19:22Z","timestamp":1789193962899,"version":"build-2803163510"},"reference-count":37,"publisher":"IOP Publishing","issue":"6","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"French Brittany Region"},{"name":"French ANR within the Investissements d\u2019Avenir program","award":["ANR-11-LABX-0004"],"award-info":[{"award-number":["ANR-11-LABX-0004"]}]},{"name":"FOCUS project","award":["ANR-16-CE19-0011"],"award-info":[{"award-number":["ANR-16-CE19-0011"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2017,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prostate volume changes due to edema occurrence during transperineal permanent brachytherapy should be taken under consideration to ensure optimal dose delivery. Available edema models, based on prostate volume observations, face several limitations. Therefore, patient-specific models need to be developed to accurately account for the impact of edema. In this study we present a biomechanical model developed to reproduce edema resolution patterns documented in the literature. Using the biphasic mixture theory and finite element analysis, the proposed model takes into consideration the mechanical properties of the pubic area tissues in the evolution of prostate edema. The model\u2019s computed deformations are incorporated in a Monte Carlo simulation to investigate their effect on post-operative dosimetry. The comparison of Day1 and Day30 dosimetry results demonstrates the capability of the proposed model for patient-specific dosimetry improvements, considering the edema dynamics. The proposed model shows excellent ability to reproduce previously described edema resolution patterns and was validated based on previous findings. According to our results, for a prostate volume increase of 10\u201320% the Day30 urethra D10 dose metric is higher by 4.2%\u201310.5% compared to the Day1 value. The introduction of the edema dynamics in Day30 dosimetry shows a significant global dose overestimation identified on the conventional static Day30 dosimetry. In conclusion, the proposed edema biomechanical model can improve the treatment planning of transperineal permanent brachytherapy accounting for post-implant dose alterations during the planning procedure.<\/jats:p>","DOI":"10.1088\/1361-6560\/aa5d3a","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T12:14:49Z","timestamp":1485864889000},"page":"2087-2102","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Modeling the impact of prostate edema on LDR brachytherapy: a Monte Carlo dosimetry study based on a 3D biphasic finite element biomechanical model"],"prefix":"10.1088","volume":"62","author":[{"given":"K A","family":"Mountris","sequence":"first","affiliation":[{"name":"CHRU Brest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bert","sequence":"additional","affiliation":[{"name":"CHRU Brest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Noailly","sequence":"additional","affiliation":[{"name":"Universitat Pompeu Fabra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Rodriguez","family":"Aguilera","sequence":"additional","affiliation":[{"name":"University of Granada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Valeri","sequence":"additional","affiliation":[{"name":"CHRU Brest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Pradier","sequence":"additional","affiliation":[{"name":"CHRU Brest"},{"name":"CHRU Brest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Schick","sequence":"additional","affiliation":[{"name":"CHRU Brest"},{"name":"CHRU Brest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Promayon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A Gonzalez","family":"Ballester","sequence":"additional","affiliation":[{"name":"Universitat Pompeu Fabra"},{"name":"ICREA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Troccaz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Visvikis","sequence":"additional","affiliation":[{"name":"CHRU Brest"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"pmbaa5d3abib001","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cag.2015.10.002","type":"journal-article","article-title":"A parallel resampling method for interactive deformation of volumetric models","volume":"53","author":"Aguilera","year":"2015","journal-title":"Comput. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2016-10-04","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-01-31","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-02-17","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}