{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:22:55Z","timestamp":1794273775120,"version":"4.9.0"},"reference-count":10,"publisher":"IOP Publishing","issue":"8","license":[{"start":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000},"content-version":"tdm","delay-in-days":12,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"National Cancer Institute","award":["R01 CA096441"],"award-info":[{"award-number":["R01 CA096441"]}]},{"DOI":"10.13039\/100006999","name":"Nuclear Energy University Programs","doi-asserted-by":"crossref","award":["DE-FG07-06ID14773"],"award-info":[{"award-number":["DE-FG07-06ID14773"]}],"id":[{"id":"10.13039\/100006999","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Internal radiation dose estimates for diagnostic nuclear medicine procedures are typically calculated for a reference individual. Resultantly, there is uncertainty when determining the organ doses to patients who are not at 50th percentile on either height or weight. This study aims to better personalize internal radiation dose estimates for individual patients by modifying the dose estimates calculated for reference individuals based on easily obtainable morphometric characteristics of the patient. Phantoms of different sitting heights and waist circumferences were constructed based on computational reference phantoms for the newborn, 10 year-old, and adult. Monoenergetic photons and electrons were then simulated separately at 15 energies. Photon and electron specific absorbed fractions (SAFs) were computed for the newly constructed non-reference phantoms and compared to SAFs previously generated for the age-matched reference phantoms. Differences in SAFs were correlated to changes in sitting height and waist circumference to develop scaling factors that could be applied to reference SAFs as morphometry corrections. A further set of arbitrary non-reference phantoms were then constructed and used in validation studies for the SAF scaling factors. Both photon and electron dose scaling methods were found to increase average accuracy when sitting height was used as the scaling parameter (~11%). Photon waist circumference-based scaling factors showed modest increases in average accuracy (~7%) for underweight individuals, but not for overweight individuals. Electron waist circumference-based scaling factors did not show increases in average accuracy. When sitting height and waist circumference scaling factors were combined, modest average gains in accuracy were observed for photons (~6%), but not for electrons. Both photon and electron absorbed doses are more reliably scaled using scaling factors computed in this study. They can be effectively scaled using sitting height alone as patient-specific morphometric parameter.<\/jats:p>","DOI":"10.1088\/1361-6560\/aab72f","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T09:18:23Z","timestamp":1521191903000},"page":"085007","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Individualized adjustments to reference phantom internal organ dosimetry\u2014scaling factors given knowledge of patient external anatomy"],"prefix":"10.1088","volume":"63","author":[{"given":"Michael B","family":"Wayson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7175-9968","authenticated-orcid":false,"given":"Wesley E","family":"Bolch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,4,13]]},"reference":[{"key":"pmbaab72fbib001","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2967\/jnumed.109.073015","type":"journal-article","article-title":"Changes in radiation dose with variations in human anatomy: moderately and severely obese adults","volume":"51","author":"Clark","year":"2010","journal-title":"J. Nucl. Med."},{"key":"pmbaab72fbib002","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0379-0738(00)00401-1","type":"journal-article","article-title":"Organ weight in 684 adult autopsies: new tables for a Caucasoid population","volume":"119","author":"de la Grandmaison","year":"2001","journal-title":"Forensic Sci. Int."},{"key":"pmbaab72fbib003","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.1088\/0031-9155\/59\/18\/5225","type":"journal-article","article-title":"The UF\/NCI family of hybrid computational phantoms representing the current US population of male and female children, adolescents, and adults\u2014application to CT dosimetry","volume":"59","author":"Geyer","year":"2014","journal-title":"Phys. Med. Biol."},{"key":"pmbaab72fbib004","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0146-6453(03)00002-2","type":"journal-article","article-title":"ICRP publication 89: basic anatomical and physiological data for use in radiological protection\u2014reference values","volume":"32","author":"ICRP","year":"2002","journal-title":"Ann. ICRP"},{"key":"pmbaab72fbib005","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.icrp.2008.10.004","type":"journal-article","article-title":"ICRP publication 107: nuclear decay data for dosimetric calculations","volume":"38","author":"ICRP","year":"2008","journal-title":"Ann. ICRP"},{"key":"pmbaab72fbib006","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1109\/JPROC.2009.2032855","type":"journal-article","article-title":"Hybrid patient-dependent phantoms covering statistical distributions of body morphometry in the US adult and pediatric population","volume":"97","author":"Johnson","year":"2009","journal-title":"Proc. IEEE"},{"key":"pmbaab72fbib007","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1088\/0031-9155\/55\/2\/002","type":"journal-article","article-title":"The UF family of reference hybrid phantoms for computational radiation dosimetry","volume":"55","author":"Lee","year":"2010","journal-title":"Phys. Med. Biol."},{"key":"pmbaab72fbib008","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1088\/0031-9155\/57\/5\/1433","type":"journal-article","article-title":"Internal photon and electron dosimetry of the newborn patient\u2014a hybrid computational phantom study","volume":"57","author":"Wayson","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"pmbaab72fbib009","article-title":"Computational internal dosimetry methods as applied to the University of Florida series of hybrid phantoms","author":"Wayson","year":"2012","type":"other"},{"key":"pmbaab72fbib010","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aab730","type":"journal-article","article-title":"Individualized adjustments to reference phantom internal organ dosimetry - Scaling factors give knowledge of patient internal anatomy","volume":"63","author":"Wayson","year":"2018","journal-title":"Phys. Med. Biol."}],"container-title":["Physics in Medicine &amp; Biology"],"original-title":[],"link":[{"URL":"http:\/\/stacks.iop.org\/0031-9155\/63\/i=8\/a=085007?key=crossref.064c8988f52544f8a1a7587b8d2da469","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"http:\/\/stacks.iop.org\/0031-9155\/63\/i=8\/a=085007\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0031-9155\/63\/i=8\/a=085007\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0031-9155\/63\/i=8\/a=085007?key=crossref.064c8988f52544f8a1a7587b8d2da469","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:44:49Z","timestamp":1775915089000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aab72f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,1]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,4,13]]},"published-print":{"date-parts":[[2018,4,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/aab72f","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,1]]},"assertion":[{"value":"Individualized adjustments to reference phantom internal organ dosimetry\u2014scaling factors given knowledge of patient external anatomy","name":"article_title","label":"Article Title"},{"value":"Physics in Medicine & Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2018 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-11-06","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-03-16","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-04-13","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}