{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:44:59Z","timestamp":1775918699840,"version":"3.50.1"},"reference-count":26,"publisher":"IOP Publishing","issue":"16","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"tdm","delay-in-days":9,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["U19-AI091173"],"award-info":[{"award-number":["U19-AI091173"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Health and Human Services, Biomedical Advanced Research and Development Authority","award":["HHSO100201100024C"],"award-info":[{"award-number":["HHSO100201100024C"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In a large-scale radiation event, thousands may be exposed to unknown amounts of radiation, some of which may be life-threatening without immediate attention. In such situations, a method to quickly and reliably estimate dose would help medical responders triage victims to receive life-saving care. We developed such a method using electron paramagnetic resonance (EPR) to make\n                    <jats:italic>in vivo<\/jats:italic>\n                    measurements of the maxillary incisors. This report provides evidence that the use of\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies can provide data that are fully representative of the measurements made\n                    <jats:italic>in vivo<\/jats:italic>\n                    . This is necessary because, in order to systematically test and improve the reliability and accuracy of the dose estimates made with our EPR dosimetry system, it is important to conduct controlled studies\n                    <jats:italic>in vitro<\/jats:italic>\n                    using irradiated human teeth. Therefore, it is imperative to validate whether our\n                    <jats:italic>in vitro<\/jats:italic>\n                    models adequately simulate the measurements made\n                    <jats:italic>in vivo,<\/jats:italic>\n                    which are intended to help guide decisions on triage after a radiation event.\n                  <\/jats:p>\n                  <jats:p>\n                    Using a healthy volunteer with a dentition gap that allows using a partial denture, human teeth were serially irradiated\n                    <jats:italic>in vitro<\/jats:italic>\n                    and then, using a partial denture, placed in the volunteer\u2019s mouth for measurements. We compared dose estimates made using\n                    <jats:italic>in vivo<\/jats:italic>\n                    measurements made in the volunteer\u2019s mouth to measurements made on the same teeth in our complex mouth model that simulates electromagnetic and anatomic properties of the mouth. Our results demonstrate that this mouth model can be used in\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies to develop the system because these measurements appropriately model\n                    <jats:italic>in vivo<\/jats:italic>\n                    conditions.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/aad518","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T06:45:17Z","timestamp":1532328317000},"page":"165002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of a novel mouth model as an alternative tool to test the effectiveness of an\n                    <i>in vivo<\/i>\n                    EPR dosimetry system"],"prefix":"10.1088","volume":"63","author":[{"given":"Kyo","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Javier","family":"Nicolalde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaixin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin B","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaichi-Chang-Il","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold M","family":"Swartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Barry","family":"Flood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"pmbaad518bib001","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/rpd\/ncq499","type":"journal-article","article-title":"Review of retrospective dosimetry techniques for external ionising radiation exposures","volume":"147","author":"Ainsbury","year":"2011","journal-title":"Radiat. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-04-16","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-07-23","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-08-10","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}