{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:47:21Z","timestamp":1791917241455,"version":"4.3.4"},"reference-count":44,"publisher":"IOP Publishing","issue":"22","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"tdm","delay-in-days":11,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01 HL071021"],"award-info":[{"award-number":["R01 HL071021"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cardiac positron emission tomography (PET) imaging suffers from image blurring due to the constant motion of the heart that can impact interpretation. Hybrid PET\/magnetic resonance (MR) has the potential to use radiation-free MR imaging to correct for the effects of cardio-respiratory motion in the PET data, improving qualitative and quantitative PET imaging in the heart. The purpose of this study was (i) to implement a MR image-based motion-corrected PET\/MR method and (ii) to perform a proof-of-concept study of quantitative myocardial PET data in patients.<\/jats:p>\n                  <jats:p>The proposed method takes reconstructions of respiratory and cardiac gated PET data and applies spatial transformations to a single reference frame before averaging to form a single motion-corrected PET (MC-PET) image. Motion vector fields (MVFs) describing the transformations were derived from affine or non-rigid registration of respiratory and cardiac gated MR data.<\/jats:p>\n                  <jats:p>\n                    Eight patients with suspected cardiac sarcoidosis underwent cardiac PET\/MR imaging after injection of 5 MBq kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    of\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorodeoxyglucose (\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG). Myocardial regions affected by motion were identified by expert readers within which target-to-background ratios (TBR) and contrast-to-noise ratios (CNR) were measured on non-MC-non-gated, MC-PET, and double respiratory and cardiac gated PET images. Paired\n                    <jats:italic>t<\/jats:italic>\n                    -tests were used to determine statistical differences in quantitative uptake-measures between the different types of PET images.\n                  <\/jats:p>\n                  <jats:p>\n                    MC-PET images showed less blurring compared to non-MC-non-gated PET and tracer activity qualitatively aligned better with the underlying myocardial anatomy when fused with MR. TBR and CNR were significantly greater for MC-PET (2.8\u2009\u2009\u00b1\u2009\u20090.9; 21\u2009\u2009\u00b1\u2009\u200922) compared to non-MC-non-gated PET (2.4\u2009\u2009\u00b1\u2009\u20090.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.0001; 15\u2009\u2009\u00b1\u2009\u200913,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.02), while TBR was lower and CNR greater compared to double-gated PET (3.2\u2009\u2009\u00b1\u2009\u20090.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.04; 6\u2009\u2009\u00b1\u2009\u20093,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.004).\n                  <\/jats:p>\n                  <jats:p>This study demonstrated in a patient cohort that motion-corrected (MC) cardiac PET\/MR is feasible using a retrospective MR image-based method and that improvement in TBR and CNR are achievable. MC PET\/MR holds promise for improving interpretation and quantification in cardiac PET imaging.<\/jats:p>","DOI":"10.1088\/1361-6560\/aaea97","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T21:48:19Z","timestamp":1540331299000},"page":"225011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Correction of respiratory and cardiac motion in cardiac PET\/MR using MR-based motion modeling"],"prefix":"10.1088","volume":"63","author":[{"given":"Philip M","family":"Robson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MariaGiovanna","family":"Trivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas A","family":"Karakatsanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Abgral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R","family":"Dweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C","family":"Kovacic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi A","family":"Fayad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"pmbaaea97bib001","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.jcmg.2016.02.029","type":"journal-article","article-title":"Clinical utility of combined FDG-PET\/MR to assess myocardial disease","volume":"10","author":"Abgral","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"pmbaaea97bib002","doi-asserted-by":"publisher","first-page":"78","DOI":"10.2967\/jnumed.115.154757","type":"journal-article","article-title":"Impact of point-spread function modeling on PET image quality in integrated PET\/MR hybrid imaging","volume":"57","author":"Aklan","year":"2016","journal-title":"J. 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