{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T12:59:40Z","timestamp":1770555580005,"version":"3.49.0"},"reference-count":28,"publisher":"IOP Publishing","issue":"13","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"tdm","delay-in-days":1,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2017R1C1B1006636"],"award-info":[{"award-number":["2017R1C1B1006636"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A patient-specific applicator guide system (PSAG) for tongue-cancer high-dose-rate (HDR) interstitial brachytherapy (ISBT) was developed by utilizing a 3D printing technique. An effectiveness of the 3D-printed PSAG (3D-PSAG) was evaluated for HDR ISBT. Six patients with tongue cancer were retrospectively selected for this study. For each patient, a total of three virtual clinical target volumes (CTV) requiring the insertion of four catheters (CTV4), six catheters (CTV6), and eight catheters (CTV8) were defined. For each CTV, treatment plans were generated to deliver 45 Gy in nine fractions. The 3D-PSAG was fabricated using a 3D-printer and the patient\u2019s CT-images. The resulting 3D-PSAG took the form of a shell conforming to the patient\u2019s contours with tubes for catheter insertion. For each CTV, catheters were inserted into the phantom with and without the 3D-PSAG. After that, CT-images of the phantom with the inserted catheters were acquired. Differences between the planned positions and those of the actually inserted catheters were evaluated from the CT-images. Given the actual catheter insertion positions, the dose distributions were reconstructed and analyzed. The maximum positional errors with and without the 3D-PSAG were 0.2\u2009mm and 4.5\u2009mm, respectively. For CTV6, the\n                    <jats:italic>D<\/jats:italic>\n                    <jats:sub>90%<\/jats:sub>\n                    values of the original plan, the reconstructed plan with the 3D-PSAG, and the reconstructed plan without the 3D-PSAG, were 48.8\u2009\u2009\u00b1\u2009\u20091.7 Gy, 49.0\u2009\u2009\u00b1\u2009\u20092.9 Gy, and 45.6\u2009\u2009\u00b1\u2009\u20093.3 Gy, respectively. The\n                    <jats:italic>D<\/jats:italic>\n                    <jats:sub>1cc<\/jats:sub>\n                    values for the mandible were 51.3\u2009\u2009\u00b1\u2009\u20099.2 Gy, 61.6\u2009\u2009\u00b1\u2009\u20098.3 Gy, and 81.1\u2009\u2009\u00b1\u2009\u200916.7 Gy, respectively. The dose homogeneities in the CTVs into which the catheters had been inserted with the 3D-PSAG were always superior to those into which the catheters had been inserted without the 3D-PSAG. The present phantom study demonstrated the feasibility of more accurate interstitial tongue brachytherapy while simplifying the treatment process by utilizing the 3D-PSAG.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/ab277e","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T18:15:27Z","timestamp":1559844927000},"page":"135002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["A 3D-printed patient-specific applicator guide for use in high-dose-rate interstitial brachytherapy for tongue cancer: a phantom study"],"prefix":"10.1088","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-1372","authenticated-orcid":false,"given":"Chang Heon","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-in","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-3870","authenticated-orcid":false,"given":"Jong Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"pmbab277ebib001","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.brachy.2015.10.001","type":"journal-article","article-title":"Computed tomography\u2013planned interstitial brachytherapy for locally advanced gynecologic cancer: outcomes and dosimetric predictors of urinary toxicity","volume":"15","author":"Amsbaugh","year":"2016","journal-title":"Brachytherapy"},{"key":"pmbab277ebib002","doi-asserted-by":"publisher","first-page":"56","DOI":"10.5114\/jcb.2016.58082","type":"journal-article","article-title":"High-dose-rate interstitial brachytherapy in early stage oral tongue cancer-15 year experience from a tertiary care institute","volume":"8","author":"Bansal","year":"2016","journal-title":"J. Contemp. Brachyther."},{"key":"pmbab277ebib003","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.brachy.2011.05.005","type":"journal-article","article-title":"Three-dimensional image-based high-dose-rate interstitial brachytherapy for vaginal cancer","volume":"11","author":"Beriwal","year":"2012","journal-title":"Brachytherapy"},{"key":"pmbab277ebib004","doi-asserted-by":"publisher","first-page":"39","DOI":"10.14316\/pmp.2017.28.2.39","type":"journal-article","article-title":"Evaluation of dosimetric effect and treatment time by plan parameters for endobronchial brachytherapy","volume":"28","author":"Choi","year":"2017","journal-title":"Prog. Med. Phy."},{"key":"pmbab277ebib005","doi-asserted-by":"publisher","first-page":"e0205229","DOI":"10.1371\/journal.pone.0205229","type":"journal-article","article-title":"Comparison of the IPSA and HIPO algorithms for interstitial tongue high-dose-rate brachytherapy","volume":"13","author":"Choi","year":"2018","journal-title":"PLoS One"},{"key":"pmbab277ebib006","author":"ICRU","year":"1997","type":"book"},{"key":"pmbab277ebib007","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0360-3016(01)01561-9","type":"journal-article","article-title":"Phase III trial of high-versus low-dose-rate interstitial radiotherapy for early mobile tongue cancer","volume":"51","author":"Inoue","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. 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Radiol."},{"key":"pmbab277ebib010","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0167-8140(03)00055-0","type":"journal-article","article-title":"Results of low-and high-dose-rate interstitial brachytherapy for T3 mobile tongue cancer","volume":"68","author":"Kakimoto","year":"2003","journal-title":"Radiother. Oncol."},{"key":"pmbab277ebib011","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3857\/roj.2017.00122","type":"journal-article","article-title":"Reirradiation of head and neck cancer in the era of intensity-modulated radiotherapy: patient selection, practical aspects, and current evidence","volume":"35","author":"Kim","year":"2017","journal-title":"Radiat. Oncol. J."},{"key":"pmbab277ebib012","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s000660050031","type":"journal-article","article-title":"CT-based interstitial HDR brachytherapy","volume":"175","author":"Kolotas","year":"1999","journal-title":"Strahlenther. 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J."},{"key":"pmbab277ebib020","doi-asserted-by":"publisher","first-page":"990","DOI":"10.18203\/2320-6012.ijrms20180628","type":"journal-article","article-title":"Impact of discrete source step size on the 3D dosimetry of interstitial implants with high dose rate brachytherapy","volume":"6","author":"Maurya","year":"2018","journal-title":"Int. J. Res. Med. Sci."},{"key":"pmbab277ebib021","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.brachy.2014.08.050","type":"journal-article","article-title":"High-dose-rate brachytherapy in early oral cancer with close or positive margins","volume":"14","author":"Petera","year":"2015","journal-title":"Brachytherapy"},{"key":"pmbab277ebib022","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1118\/1.1646040","type":"journal-article","article-title":"Update of AAPM Task Group No. 43 Report: a revised AAPM protocol for brachytherapy dose calculations","volume":"31","author":"Rivard","year":"2004","journal-title":"Med. 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Brachytherapy"}],"container-title":["Physics in Medicine &amp; Biology"],"original-title":[],"link":[{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:18:58Z","timestamp":1770466738000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab277e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":28,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2019,7,2]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/ab277e","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,1]]},"assertion":[{"value":"A 3D-printed patient-specific applicator guide for use in high-dose-rate interstitial brachytherapy for tongue cancer: a phantom study","name":"article_title","label":"Article Title"},{"value":"Physics in Medicine & Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2019 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-12-24","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-06-06","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-07-02","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}