{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T12:20:17Z","timestamp":1770553217562,"version":"3.49.0"},"reference-count":13,"publisher":"IOP Publishing","issue":"17","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"tdm","delay-in-days":4,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Licensing agreement with RaySearch Laboratories"},{"name":"NIH\/NCI Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Award","award":["P50 CA097007"],"award-info":[{"award-number":["P50 CA097007"]}]},{"name":"NIH\/NCI Cancer Center Support Grant (CCSG) Pilot Research Program Award from the UT MD Anderson CCSG Radiation Oncology and Cancer Imaging Program","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}]},{"name":"NCI Early Phase Clinical Trials in Imaging and Image-Guided Interventions Program","award":["1R01CA218148"],"award-info":[{"award-number":["1R01CA218148"]}]},{"name":"NIH Big Data to Knowledge (BD2K) Program of the National Cancer Institute (NCI) Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science Award","award":["1R01CA214825"],"award-info":[{"award-number":["1R01CA214825"]}]},{"name":"National Institute of Biomedical Imaging and Bioengineering (NIBIB) Research Education Programs for Residents and Clinical Fellows Grant","award":["R25EB025787-01"],"award-info":[{"award-number":["R25EB025787-01"]}]},{"name":"National Science Foundation (NSF), Division of Mathematical Sciences, Joint NIH\/NSF Initiative on Quantitative Approaches to Biomedical Big Data (QuBBD) Grant","award":["NSF 1557679"],"award-info":[{"award-number":["NSF 1557679"]}]},{"name":"National Institute for Dental and Craniofacial Research Award","award":["1R01DE025248\/R56DE025248"],"award-info":[{"award-number":["1R01DE025248\/R56DE025248"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During head and neck (HN) cancer radiation therapy, analysis of the dose-response relationship for the parotid glands (PG) relies on the ability to accurately align soft tissue organs between longitudinal images. In order to isolate the response of the salivary glands to delivered dose, from deformation due to patient position, it is important to resolve the patient postural changes, mainly due to neck flexion. In this study we evaluate the use of a biomechanical model-based deformable image registration (DIR) algorithm to estimate the displacements and deformations of the salivary glands due to postural changes.<\/jats:p>\n                  <jats:p>A total of 82 pairs of CT images of HN cancer patients with varying angles of neck flexion were retrospectively obtained. The pairs of CTs of each patient were aligned using bone-based rigid registration. The images were then deformed using biomechanical model-based DIR method that focused on the mandible, C1 vertebrae, C3 vertebrae, and external contour. For comparison, an intensity-based DIR was also performed. The accuracy of the biomechanical model-based DIR was assessed using Dice similarity coefficient (DSC) for all images and for the subset of images where the PGs had a volume change within 20%. The accuracy was compared to the intensity-based DIR.<\/jats:p>\n                  <jats:p>\n                    The PG mean\u2009\u2009\u00b1\u2009\u2009STD DSC were 0.63\u2009\u2009\u00b1\u2009\u20090.18, 0.80\u2009\u2009\u00b1\u2009\u20090.08, and 0.82\u2009\u2009\u00b1\u2009\u20090.15 for the rigid registration, biomechanical model-based DIR, and intensity based DIR, respectively, for patients with a PG volume change up to 20%. For the entire cohort of patients, where the PG volume change was up to 57%, the PG mean\u2009\u2009\u00b1\u2009\u2009STD DSC were 0.60\u2009\u2009\u00b1\u2009\u20090.18, 0.78\u2009\u2009\u00b1\u2009\u20090.09, and 0.81\u2009\u2009\u00b1\u2009\u20090.14 for the rigid registration, biomechanical model-based DIR, and intensity based DIR, respectively. The difference in DSC of the intensity and biomechanical model-based DIR methods was not statistically significant when the volume change was less than 20% (two-sided paired\n                    <jats:italic>t<\/jats:italic>\n                    -test,\n                    <jats:italic>p<\/jats:italic>\n                    \u200a\u2009\u2009=\u2009\u20090.12). When all volume changes were considered, there was a significant difference between the two registration approaches, although the magnitude was small.\n                  <\/jats:p>\n                  <jats:p>These results demonstrate that the proposed biomechanical model with boundary conditions on the bony anatomy can serve to describe the varying angles of neck flexion appearing in images during radiation treatment and to align the salivary glands for proper analysis of dose-response relationships. It also motivates the need for dose response modeling following neck flexion for cases where parotid gland response is noted.<\/jats:p>","DOI":"10.1088\/1361-6560\/ab2f13","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T18:30:24Z","timestamp":1562178624000},"page":"175018","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Biomechanical modeling of neck flexion for deformable alignment of the salivary glands in head and neck cancer images"],"prefix":"10.1088","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-1263","authenticated-orcid":false,"given":"Molly M","family":"McCulloch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-1444","authenticated-orcid":false,"given":"Brian M","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-7602","authenticated-orcid":false,"given":"Guillaume","family":"Cazoulat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-0468","authenticated-orcid":false,"given":"Christine B","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-7613","authenticated-orcid":false,"given":"Abdallah S R","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-2964","authenticated-orcid":false,"given":"Stefania","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-2623","authenticated-orcid":false,"given":"Hesham","family":"Elhalawani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9508-0602","authenticated-orcid":false,"given":"Houda","family":"Bahig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0038-429X","authenticated-orcid":false,"given":"Bastien","family":"Rigaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-7420","authenticated-orcid":false,"given":"Jason B","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-7539","authenticated-orcid":false,"given":"Alexandra C","family":"Ford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-3994","authenticated-orcid":false,"given":"Clifton D","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-5040","authenticated-orcid":false,"given":"Kristy K","family":"Brock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"pmbab2f13bib001","doi-asserted-by":"publisher","first-page":"8481","DOI":"10.1088\/0031-9155\/60\/21\/8481","type":"journal-article","article-title":"Radiation dose response simulation for biomechanical-based deformable image registration of head and neck cancer treatment","volume":"60","author":"Al-Mayah","year":"2015","journal-title":"Phys. Med. Biol."},{"key":"pmbab2f13bib002","doi-asserted-by":"publisher","first-page":"6491","DOI":"10.1088\/0031-9155\/55\/21\/010","type":"journal-article","article-title":"Biomechanical-based image registration for head and neck radiation treatment","volume":"55","author":"Al-Mayah","year":"2010","journal-title":"Phys. Med. Biol."},{"key":"pmbab2f13bib003","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1118\/1.1915012","type":"journal-article","article-title":"Accuracy of finite element model-based multi-organ deformable image registration","volume":"32","author":"Brock","year":"2005","journal-title":"Med. Phys."},{"key":"pmbab2f13bib004","doi-asserted-by":"publisher","first-page":"S58","DOI":"10.1016\/j.ijrobp.2009.06.090","type":"journal-article","article-title":"Radiotherapy dose\u2013volume effects on salivary gland function","volume":"76","author":"Deasy","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"pmbab2f13bib0001a","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.ijrobp.2016.02.021","type":"journal-article","article-title":"Clinical outcomes and patterns of disease recurrence after intensity modulated proton therapy for oropharyngeal squamous carcinoma","volume":"95","author":"Gunn","year":"2016","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"pmbab2f13bib005","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aa9dc2","type":"journal-article","article-title":"An automated, quantitative, and case-specific evaluation of deformable image registration in computed tomography images","volume":"63","author":"Kierkels","year":"2018","journal-title":"Phys. Med. Biol."},{"key":"pmbab2f13bib006","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.ijrobp.2004.12.035","type":"journal-article","article-title":"Volume effects and region-dependent radiosensitivity of the PG","volume":"62","author":"Konings","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"pmbab2f13bib007","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cmpb.2017.11.001","type":"journal-article","article-title":"An automated dose tracking system for adaptive radiation therapy","volume":"154","author":"Liu","year":"2018","journal-title":"Comput. Methods Prog. Biomed."},{"key":"pmbab2f13bib008","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/mp.12737","type":"journal-article","article-title":"Performance of commercially available deformable image registration platforms for contour propagation using patient-based computational phantoms: a multi-institutional study","volume":"45","author":"Loi","year":"2018","journal-title":"Med. Phys."},{"key":"pmbab2f13bib009","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ijrobp.2010.10.019","type":"journal-article","article-title":"Variations in the contouring of organs at risk: test case from a patient with oropharyngeal cancer","volume":"82","author":"Nelms","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"pmbab2f13bib010","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.radonc.2017.10.004","type":"journal-article","article-title":"Automated, reference-free local error assessment of multimodal deformable image registration for radiotherapy in the head and neck","volume":"125","author":"Nix","year":"2017","journal-title":"Radiother. Oncol."},{"key":"pmbab2f13bib011","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.ijrobp.2014.12.045","type":"journal-article","article-title":"Long-term quality of life after swallowing and salivary-sparing chemo\u2013intensity modulated radiation therapy in survivors of human papillomavirus\u2013related oropharyngeal cancer","volume":"91","author":"Vainshtein","year":"2015","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"pmbab2f13bib012","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1118\/1.4894702","type":"journal-article","article-title":"The ANACONDA algorithm for deformable image registration in radiotherapy","volume":"42","author":"Weistrand","year":"2015","journal-title":"Med. Phys."}],"container-title":["Physics in Medicine &amp; Biology"],"original-title":[],"link":[{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:31:20Z","timestamp":1770467480000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ab2f13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,1]]},"references-count":13,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2019,9,5]]},"published-print":{"date-parts":[[2019,9,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/ab2f13","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,1]]},"assertion":[{"value":"Biomechanical modeling of neck flexion for deformable alignment of the salivary glands in head and neck cancer images","name":"article_title","label":"Article Title"},{"value":"Physics in Medicine & Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2019 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-12-06","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-07-03","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-09-05","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}