{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:02:13Z","timestamp":1793901733849,"version":"4.8.0"},"reference-count":34,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Grants-in-Aid","award":["Program for Leading Graduate Schools from the Japa"],"award-info":[{"award-number":["Program for Leading Graduate Schools from the Japa"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"Abstract<\/jats:title>\n The Compton camera can simultaneously acquire images of multiple isotopes injected in a body; therefore, it has the potential to introduce a new subfield in the field of biomedical imaging applications. The objective of this study is to assess the ability of a prototype semiconductor-based silicon\/cadmium telluride (Si\/CdTe) Compton camera to simultaneously image the distributions of technetium (99m<\/jats:sup>Tc)-dimercaptosuccinic acid (DMSA) (141\u2009keV emission) and 18<\/jats:sup>F-fluorodeoxyglucose (FDG) (511\u2009keV emission) injected into a human volunteer.<\/jats:p>\n \n 99m<\/jats:sup>Tc-DMSA and 18<\/jats:sup>F-FDG were injected intravenously into a 25-year-old male volunteer. The distributions of 99m<\/jats:sup>Tc-DMSA and 18<\/jats:sup>F-FDG were simultaneously made visible by setting a specified energy window for each radioisotope. The images of these radiopharmaceuticals acquired using the prototype Compton camera were superimposed onto computed tomography images for reference.<\/jats:p>\n The reconstructed image showed that 99m<\/jats:sup>Tc-DMSA had accumulated in both kidneys, which is consistent with the well-known diagnostic distribution determined by clinical imaging via single-photon emission computed tomography. In the 18<\/jats:sup>F-FDG image, there is broad distribution around the liver and kidneys, which was expected based on routine clinical positron emission tomography imaging.<\/jats:p>\n The current study demonstrated for the first time that the Si\/CdTe Compton camera was capable of simultaneously imaging the distributions of two radiopharmaceuticals, 99m<\/jats:sup>Tc-DMSA and 18<\/jats:sup>F-FDG, in a human body. These results suggest that the Si\/CdTe Compton camera has the potential to become a novel modality for nuclear medical diagnoses enabling multi-probe simultaneous tracking.<\/jats:p>","DOI":"10.1088\/1361-6560\/ab33d8","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T22:45:41Z","timestamp":1563576341000},"page":"05LT01","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Imaging of 99m<\/sup>Tc-DMSA and 18<\/sup>F-FDG in humans using a Si\/CdTe Compton camera"],"prefix":"10.1088","volume":"65","author":[{"given":"Takashi","family":"Nakano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-2375","authenticated-orcid":false,"given":"Makoto","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-1613","authenticated-orcid":false,"given":"Kota","family":"Torikai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2019ichiro","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ei","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-4066","authenticated-orcid":false,"given":"Mitsutaka","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Odaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomihiro","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-5035","authenticated-orcid":false,"given":"Naoki","family":"Kawachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadayuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"pmbab33d8bib001","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1007\/s00259-018-4129-6","article-title":"The SNMMI and EANM practice guideline for renal scintigraphy in adults","volume":"45","author":"Blaufox","year":"2018","journal-title":"Eur. 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