{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:12Z","timestamp":1778825292390,"version":"3.51.4"},"reference-count":49,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"tdm","delay-in-days":15,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL135734"],"award-info":[{"award-number":["R01HL135734"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"Abstract<\/jats:title>\n \n Pulse wave imaging (PWI) is a non-invasive, ultrasound-based technique, which provides information on arterial wall stiffness by estimating the pulse wave velocity (PWV) along an imaged arterial wall segment. The aims of the present study were to: (1) utilize the PWI information to automatically and optimally divide the artery into the segments with most homogeneous properties and (2) assess the feasibility of this method to provide arterial wall mechanical characterization in normal and atherosclerotic carotid arteries\n in vivo<\/jats:italic>\n . A silicone phantom consisting of a soft and stiff segment along its longitudinal axis was scanned at the stiffness transition, and the PWV in each segment was estimated through static testing. The proposed algorithm detected the stiffness interface with an average error of 0.98\u2009\u2009\u00b1\u2009\u20090.49\u2009mm and 1.04\u2009\u2009\u00b1\u2009\u20090.27\u2009mm in the soft-to-stiff and stiff-to-soft pulse wave transmission direction, respectively. Mean PWVs estimated in the case of the soft-to-stiff pulse wave transmission direction were 2.47\n \n 0.04 m s\n \u22121<\/jats:sup>\n and 3.43\n \n 0.08 m s\n \u22121<\/jats:sup>\n for the soft and stiff phantom segments, respectively, while in the case of stiff-to-soft transmission direction PWVs were 2.60\n \n 0.18 m s\n \u22121<\/jats:sup>\n and 3.72\n \n 0.08 m s\n \u22121<\/jats:sup>\n for the soft and stiff phantom segments, respectively, which were in good agreement with the PWVs obtained through static testing (soft segment: 2.41 m s\n \u22121<\/jats:sup>\n , stiff segment: 3.52 m s\n \u22121<\/jats:sup>\n ). Furthermore, the carotid arteries of\n N<\/jats:italic>\n \u2009\u2009=\u2009\u20099 young subjects (22\u201332 y.o.) and\n N<\/jats:italic>\n \u2009\u2009=\u2009\u20099 elderly subjects (60\u201373 y.o.) with no prior history of carotid artery disease were scanned,\n in vivo<\/jats:italic>\n , as well as the atherosclerotic carotid arteries of\n N<\/jats:italic>\n \u2009\u2009=\u2009\u200912 (59\u201385 y.o.) carotid artery disease patients. One-way ANOVA with Holm-Sidak correction showed that the number of most homogeneous segments in which the artery was divided was significantly higher in the case of carotid artery disease patients compared to young (3.25\n \n 0.86 segments versus 1.00\n \n 0.00 segments,\n p<\/jats:italic>\n \u200a-value\u2009\u2009<\u2009\u20090.0001) and elderly non-atherosclerotic subjects (3.25\n \n 0.86 segments versus 1.44\n \n 0.51 segments\n p<\/jats:italic>\n \u200a-value\u2009\u2009<\u2009\u20090.0001), indicating increased wall inhomogeneity in atherosclerotic arteries. The compliance provided by the proposed algorithm was significantly higher in non-calcified\/high-lipid plaques as compared with calcified plaques (3.35\n \n 2.45 *\n \n versus 0.22\n \n 0.18 *\n \n ,\n p<\/jats:italic>\n \u200a-value\u2009\u2009<\u2009\u20090.01) and the compliance estimated in elderly subjects (3.35\n \n 2.45 *\n \n versus 0.79\n \n 0.30 *\n \n ,\n p<\/jats:italic>\n \u200a-value\u2009\u2009<\u2009\u20090.01). Moreover, lower compliance was estimated in cases where vulnerable plaque characteristics were present (i.e. necrotic lipid core, thrombus), compared to stable plaque components (calcification), as evaluated through plaque histological examination. The proposed algorithm was thus capable of evaluating arterial wall inhomogeneity and characterize wall mechanical properties, showing promise in vascular disease diagnosis and monitoring.\n <\/jats:p>","DOI":"10.1088\/1361-6560\/ab58fa","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T18:00:19Z","timestamp":1574186419000},"page":"025010","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Arterial wall mechanical inhomogeneity detection and atherosclerotic plaque characterization using high frame rate pulse wave imaging in carotid artery disease patients\n in vivo<\/i>"],"prefix":"10.1088","volume":"65","author":[{"given":"Grigorios M","family":"Karageorgos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iason Z","family":"Apostolakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Nauleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E Sander","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7108-8906","authenticated-orcid":false,"given":"Eliza C","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa E","family":"Konofagou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"pmbab58fabib001","article-title":"2D and 3D high frame-rate pulse wave imaging for the characterization of focal vascular disease","author":"Apostolakis","year":"2018","type":"other"},{"key":"pmbab58fabib002","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1109\/tmi.2019.2926141","type":"journal-article","article-title":"Adaptive pulse wave imaging: automated spatial vessel wall inhomogeneity detection in phantoms and in vivo","volume":"39","author":"Apostolakis","year":"2019","journal-title":"IEEE Trans. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2019-06-14","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-11-19","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-01-16","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}