{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:56:20Z","timestamp":1793912180191,"version":"4.8.0"},"reference-count":19,"publisher":"IOP Publishing","issue":"22","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Institutional Research Grant Program at the University of Texas MD Anderson Cancer Center"},{"name":"Image Guided Cancer Therapy Research Program at the University of Texas MD Anderson Cancer Center"},{"name":"Cao Thoracic Cancer Research Fund"},{"name":"Helen Black Image-Guided Fund"},{"name":"Grant from the Apache Foundation"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2020,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During minimally invasive surgery (MIS) for lung tumor resection, the localization of tumors or nodules relies on visual inspection of the deflated lung on intra-procedural video. For patients with tumors or nodules located deeper in the lung, this localization is not possible without prior invasive marking techniques. In efforts to avoid the increase of complication rates associated with these invasive techniques, this study investigates the use of biomechanical modeling of the lung deflation to predict the tumor localization during MIS, solely based on a pre-operative computed tomography (CT) scan. The feasibility of the proposed approach is evaluated using preliminary data from six patients who presented with pneumothorax after lung biopsy and underwent chest tube insertion. For each patient, a hyperelastic finite-element model of the lung was created from the CT scan showing the re-inflated lung. Boundary conditions were applied on the lung surface to simulate the gravity and insufflation of carbon dioxide in the chest. The impact of adding rigid constraints around the main airway was also evaluated. To evaluate the accuracy of the model in predicting lung tissues or potential tumor displacement, at least five corresponding landmarks were identified for each patient in the CT scans of their deflated and re-inflated lungs. Using these landmarks, target localization errors (TLE) were measured for different sets of pressure applied to lung surface and shear modulus. For five patients, the minimum achieved mean TLE was inferior to 9 mm using patient-specific parameters and inferior to 10 mm using the same parameterization. The predicted and ground truth deflated lung surfaces presented visually a relatively good agreement. The proposed approach thus appears as a promising tool for integration in future lung surgery image-guidance systems.<\/jats:p>","DOI":"10.1088\/1361-6560\/abb6ba","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T18:32:17Z","timestamp":1599676337000},"page":"225010","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Preliminary evaluation of biomechanical modeling of lung deflation during minimally invasive surgery using pneumothorax computed tomography scans"],"prefix":"10.1088","volume":"65","author":[{"given":"Anne-C\u00e9cile","family":"Lesage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Rajaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alda","family":"L Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Rigaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"K Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"C Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cazoulat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"pmbabb6babib1","doi-asserted-by":"publisher","first-page":"4560","DOI":"10.1118\/1.3471020","type":"journal-article","article-title":"Deformable image registration of heterogeneous human lung incorporating the bronchial tree","volume":"37","author":"Al-Mayah","year":"2010","journal-title":"Med. Phys."},{"key":"pmbabb6babib2","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1109\/ISBI.2019.8759219","type":"conference-proceedings","article-title":"Biphasic model of lung deformations for video-assisted thoracoscopic surgery (VATS)","author":"Alvarez","year":"2019"},{"key":"pmbabb6babib3","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1118\/1.1915012","type":"journal-article","article-title":"Accuracy of finite element model\u2010based multi\u2010organ deformable image registration","volume":"32","author":"Brock","year":"2005","journal-title":"Med. Phys."},{"key":"pmbabb6babib4","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3978\/j.issn.2225-319X.2014.03.08","type":"journal-article","article-title":"Meta-analysis of intentional sublobar resections versus lobectomy for early stage non-small cell lung cancer","volume":"3","author":"Cao","year":"2014","journal-title":"Ann. Cardiothoracic Surg."},{"key":"pmbabb6babib5","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/icvts\/ivs472","type":"journal-article","article-title":"Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer: a meta-analysis of propensity score-matched patients","volume":"16","author":"Cao","year":"2013","journal-title":"Interact. Cardiovascular Thoracic Surg."},{"key":"pmbabb6babib6","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1088\/0031-9155\/61\/13\/4826","type":"journal-article","article-title":"Biomechanical deformable image registration of longitudinal lung CT images using vessel information","volume":"61","author":"Cazoulat","year":"2016","journal-title":"Phys. Med. Biol."},{"key":"pmbabb6babib7","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1056\/NEJMoa1209120","type":"journal-article","article-title":"Results of initial low-dose computed tomographic screening for lung cancer","volume":"368","author":"Church","year":"2013","journal-title":"New Engl. J. Med."},{"key":"pmbabb6babib8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2307\/1932409","type":"journal-article","article-title":"Measures of the amount of ecologic association between species","volume":"26","author":"Dice","year":"1945","journal-title":"Ecology"},{"key":"pmbabb6babib9","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1109\/TMI.2014.2363611","type":"journal-article","article-title":"Patient-specific biomechanical model for the prediction of lung motion from 4D CT images","volume":"34","author":"Fuerst","year":"2014","journal-title":"IEEE Trans. Med. Imaging"},{"key":"pmbabb6babib10","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1109\/34.232073","type":"journal-article","article-title":"Comparing images using the Hausdorff distance","volume":"15","author":"Huttenlocher","year":"1993","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"pmbabb6babib11","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1109\/TBME.2011.2160637","type":"journal-article","article-title":"Measurement of lung hyperelastic properties using inverse finite element approach","volume":"58","author":"Naini","year":"2011","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"pmbabb6babib12","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1007\/s11548-019-02010","type":"journal-article","article-title":"Surface deformation analysis of collapsed lungs using model-based shape matching","volume":"14","author":"Nakao","year":"2019","journal-title":"Int. J. Comput. Assisted Radiol. Surg."},{"key":"pmbabb6babib13","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1098\/rspa.1972.0026","type":"journal-article","article-title":"Large deformation isotropic elasticity\u2013on the correlation of theory and experiment for incompressible rubberlike solids","volume":"326","author":"Ogden","year":"1972","journal-title":"Proc. R. Soc. A"},{"key":"pmbabb6babib14","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.chest.2016.09.017","type":"journal-article","article-title":"Comparative effectiveness and safety of preoperative lung localization for pulmonary nodules: a systematic review and meta-analysis","volume":"151","author":"Park","year":"2017","journal-title":"Chest"},{"key":"pmbabb6babib15","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1093\/icvts\/ivw029","type":"journal-article","article-title":"Small pulmonary nodule localization with cone beam computed tomography during video-assisted thoracic surgery: a feasibility study","volume":"22","author":"Rouze","year":"2016","journal-title":"Interact. Cardiovascular Thoracic Surg."},{"key":"pmbabb6babib16","doi-asserted-by":"publisher","DOI":"10.1118\/1.4767757","type":"journal-article","article-title":"Deformable registration of the inflated and deflated lung in cone-beam CT-guided thoracic surgery: initial investigation of a combined model- and image-driven approach","volume":"40","author":"Uneri","year":"2013","journal-title":"Med. Phys."},{"key":"pmbabb6babib17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1109\/MEDIVIS.2005.15","type":"conference-proceedings","article-title":"Simulation of lung behaviour with finite elements: influence of bio-mechanical parameters","author":"Villard","year":"2005"},{"key":"pmbabb6babib18","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/ejcts\/ezv124","type":"journal-article","article-title":"Thoracoscopic ultrasonography for localization of subcentimetre lung nodules","volume":"49","author":"Wada","year":"2016","journal-title":"Eur. J. Cardiothoracic Surg."},{"key":"pmbabb6babib19","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1118\/1.1774131","type":"journal-article","article-title":"Technical note: A novel boundary condition using contact elements for finite element based deformable image registration","volume":"31","author":"Zhang","year":"2004","journal-title":"Med. Phys."}],"container-title":["Physics in Medicine &amp; Biology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:40:31Z","timestamp":1765636831000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/abb6ba"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":19,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2020,11,12]]},"published-print":{"date-parts":[[2020,11,21]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/abb6ba","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,12]]},"assertion":[{"value":"Preliminary evaluation of biomechanical modeling of lung deflation during minimally invasive surgery using pneumothorax computed tomography scans","name":"article_title","label":"Article Title"},{"value":"Physics in Medicine & Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-04-26","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-09","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-11-12","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}