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Med. Biol."],"published-print":{"date-parts":[[2020,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transcranial MRI-guided focused ultrasound (MRgFUS) is a noninvasive thermal ablation method approved for the treatment of essential tremor and tremor-dominant Parkinson\u2019s disease. This method uses MR temperature imaging (MRTI) to monitor the treatment. Accurately tracking the accumulated thermal dose is important for both safety and efficacy. Currently, MRTI is obtained in a single plane that varies between sonications, preventing direct tracking of the accumulated dose. In this work, we tested a method to estimate this dose during 120 MRgFUS treatments. This method used the MRTI to create simulated thermal images for sonications when the imaging plane was changed. This approach accurately predicted the lesion shapes. The mean S\u00f8rensen-Dice similarity coefficient between the lesion segmentations and dose regions at the 17 cumulative min at 43 \u00b0C (CEM43) threshold used by the device software was 0.82 but varied among different treatments (range: 0.34\u20130.95). Tissue swelling appeared to explain when mismatch occurred, although other errors probably contributed. Overall, the mean distance between the lesion segmentations and the 17 CEM43 dose contours was 0.37 \u00b1 0.57 mm. The probability for thermal damage was estimated to be 50% at 13.6 CEM43 and a maximum temperature of 48.6 \u00b0C. Due to large thermal gradients, which exceeded 99 CEM43\/mm on average, the area where the probability for thermal damage was uncertain was narrow. Overall these results show that the 17 CEM43 threshold is on average a good predictor for thermal lesions, although there will always be a narrow margin where the fate of the tissue is uncertain.<\/jats:p>","DOI":"10.1088\/1361-6560\/abb7c4","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T18:31:23Z","timestamp":1599849083000},"page":"235018","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["MRI-based thermal dosimetry based on single-slice imaging during focused ultrasound thalamotomy"],"prefix":"10.1088","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-5260","authenticated-orcid":false,"given":"Nathan","family":"McDannold","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Jason White","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Rees Cosgrove","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"pmbabb7c4bib1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1121\/1.1529663","type":"journal-article","article-title":"Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans","volume":"113","author":"Aubry","year":"2003","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-06-19","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-11","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-11-24","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}