{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:07:43Z","timestamp":1778782063531,"version":"3.51.4"},"reference-count":27,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"tdm","delay-in-days":6,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["18H02766"],"award-info":[{"award-number":["18H02766"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2021,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . To introduce the concept of statistical shape model (SSM)-based planning organ-at-risk volume (sPRV) for pancreatic cancer patients.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A total of 120 pancreatic cancer patients were enrolled in this study. After correcting inter-patient variations in the centroid position of the planning target volume (PTV), four different SSMs were constructed by registering a deformable template model to an individual model for the stomach and duodenum. The sPRV, which focused on the following different components of the inter-patient variations, was then created: Scenario A: shape, rotational angle, volume, and centroid position; Scenario B: shape, rotational angle, and volume; Scenario C: shape and rotational angle; and Scenario D: shape. The conventional PRV (cPRV) was created by adding an isotropic margin\n                    <jats:italic>R<\/jats:italic>\n                    (3\u201315 mm) to the mean shape model. The corresponding sPRV was created from the SSM until the volume difference between the cPRV and sPRV was less than 1%. Thereafter, we computed the overlapping volume between the PTV and cPRV (OL\n                    <jats:sub>c<\/jats:sub>\n                    ) or sPRV (OL\n                    <jats:sub>s<\/jats:sub>\n                    ) in each patient. OL\n                    <jats:sub>s<\/jats:sub>\n                    being larger than OL\n                    <jats:sub>c<\/jats:sub>\n                    implies that the local shape variations in the corresponding OAR close to the PTV were large. Therefore, OL\n                    <jats:sub>s<\/jats:sub>\n                    \/OL\n                    <jats:sub>c<\/jats:sub>\n                    was calculated in each patient for each\n                    <jats:italic>R-<\/jats:italic>\n                    value, and the median value of OL\n                    <jats:sub>s<\/jats:sub>\n                    \/OL\n                    <jats:sub>c<\/jats:sub>\n                    was regarded as a surrogate for plan quality for each\n                    <jats:italic>R-<\/jats:italic>\n                    value.\n                    <jats:italic>Results<\/jats:italic>\n                    . For\n                    <jats:italic>R<\/jats:italic>\n                    \u00a0=\u00a03 and 5 mm, OL\n                    <jats:sub>s<\/jats:sub>\n                    \/OL\n                    <jats:sub>c<\/jats:sub>\n                    exceeded 1 for the stomach and duodenum in all scenarios, with a maximum OL\n                    <jats:sub>s<\/jats:sub>\n                    \/OL\n                    <jats:sub>c<\/jats:sub>\n                    of 1.21. This indicates that smaller isotropic margins did not sufficiently account for the local shape changes close to the PTV.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Our results indicated that, in contrast to conventional PRV, SSM-based PRVs, which account for local shape changes, would result in better dose sparing for the stomach and duodenum in pancreatic cancer patients.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/abcd1b","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T18:04:58Z","timestamp":1606154698000},"page":"014001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Statistical shape model-based planning organ-at-risk volume: application to pancreatic cancer patients"],"prefix":"10.1088","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-2097","authenticated-orcid":false,"given":"Mitsuhiro","family":"Nakamura","sequence":"first","affiliation":[{"name":"Kyoto University"},{"name":"Graduate School of Medicine, Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-4366","authenticated-orcid":false,"given":"Megumi","family":"Nakao","sequence":"additional","affiliation":[{"name":"Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Mukumoto","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Ashida","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-1970","authenticated-orcid":false,"given":"Hideaki","family":"Hirashima","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-8746","authenticated-orcid":false,"given":"Takashi","family":"Mizowaki","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"pmbabcd1bbib1","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.media.2013.05.010","type":"journal-article","article-title":"Posterior shape models","volume":"17","author":"Albrecht","year":"2013","journal-title":"Med. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-06-10","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-11-23","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2021-01-13","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}