{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:13:55Z","timestamp":1778778835762,"version":"3.51.4"},"reference-count":50,"publisher":"IOP Publishing","issue":"10","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000973","name":"Cystic Fibrosis Australia","doi-asserted-by":"crossref","award":["Geelong Genetic Therapies Innovation Grant"],"award-info":[{"award-number":["Geelong Genetic Therapies Innovation Grant"]}],"id":[{"id":"10.13039\/501100000973","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100025520","name":"Medical Research Future Fund","doi-asserted-by":"crossref","award":["RFRHPSI000013"],"award-info":[{"award-number":["RFRHPSI000013"]}],"id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"crossref","award":["DONNEL21GO"],"award-info":[{"award-number":["DONNEL21GO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["FT18010037"],"award-info":[{"award-number":["FT18010037"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001164","name":"Australian Synchrotron","doi-asserted-by":"crossref","award":["International Synchrotron Access Program"],"award-info":[{"award-number":["International Synchrotron Access Program"]}],"id":[{"id":"10.13039\/501100001164","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Magnetic nanoparticles can be used as a targeted delivery vehicle for genetic therapies. Understanding how they can be manipulated within the complex environment of live airways is key to their application to cystic fibrosis and other respiratory diseases.\n                    <jats:italic>Approach.<\/jats:italic>\n                    Dark-field x-ray imaging provides sensitivity to scattering information, and allows the presence of structures smaller than the detector pixel size to be detected. In this study, ultra-fast directional dark-field synchrotron x-ray imaging was utlilised to understand how magnetic nanoparticles move within a live, anaesthetised, rat airway under the influence of static and moving magnetic fields.\n                    <jats:italic>Main results.<\/jats:italic>\n                    Magnetic nanoparticles emerging from an indwelling tracheal cannula were detectable during delivery, with dark-field imaging increasing the signal-to-noise ratio of this event by 3.5 times compared to the x-ray transmission signal. Particle movement as well as particle retention was evident. Dynamic magnetic fields could manipulate the magnetic particles\n                    <jats:italic>in situ. Significance.<\/jats:italic>\n                    This is the first evidence of the effectiveness of\n                    <jats:italic>in vivo<\/jats:italic>\n                    dark-field imaging operating at these spatial and temporal resolutions, used to detect magnetic nanoparticles. These findings provide the basis for further development toward the effective use of magnetic nanoparticles, and advance their potential as an effective delivery vehicle for genetic agents in the airways of live organisms.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/ad40f5","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T18:30:21Z","timestamp":1713551421000},"page":"105025","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultra-fast\n                    <i>in vivo<\/i>\n                    directional dark-field x-ray imaging for visualising magnetic control of particles for airway gene delivery"],"prefix":"10.1088","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-9295","authenticated-orcid":true,"given":"Ronan","family":"Smith","sequence":"first","affiliation":[{"name":"University of Adelaide"},{"name":"Women\u2019s and Children\u2019s Hospital, King William Road, Adelaide,"},{"name":"University of Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6997-7977","authenticated-orcid":true,"given":"Kaye","family":"Morgan","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"McCarron","sequence":"additional","affiliation":[{"name":"University of Adelaide"},{"name":"Women\u2019s and Children\u2019s Hospital, King William Road, Adelaide,"},{"name":"University of Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Cmielewski","sequence":"additional","affiliation":[{"name":"University of Adelaide"},{"name":"Women\u2019s and Children\u2019s Hospital, King William Road, Adelaide,"},{"name":"University of Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Reyne","sequence":"additional","affiliation":[{"name":"University of Adelaide"},{"name":"Women\u2019s and Children\u2019s Hospital, King William Road, Adelaide,"},{"name":"University of Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Parsons","sequence":"additional","affiliation":[{"name":"University of Adelaide"},{"name":"Women\u2019s and Children\u2019s Hospital, King William Road, Adelaide,"},{"name":"University of Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Donnelley","sequence":"additional","affiliation":[{"name":"University of Adelaide"},{"name":"Women\u2019s and Children\u2019s Hospital, King William Road, Adelaide,"},{"name":"University of Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"pmbad40f5bib1","doi-asserted-by":"publisher","first-page":"6449","DOI":"10.2147\/IJN.S118343","type":"journal-article","article-title":"Systemic delivery and activation of the TRAIL gene in lungs, with magnetic nanoparticles of chitosan controlled by an external magnetic field","volume":"11","author":"Alvizo-Baez","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"pmbad40f5bib2","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1038\/srep03209","type":"journal-article","article-title":"In vivo dark-field and phase-contrast x-ray imaging","volume":"3","author":"Bech","year":"2013","journal-title":"Sci. Rep."},{"key":"pmbad40f5bib3","doi-asserted-by":"publisher","first-page":"6047","DOI":"10.1118\/1.3501311","type":"journal-article","article-title":"A grating-based single-shot x-ray phase contrast and diffraction method for in vivo imaging","volume":"37","author":"Bennett","year":"2010","journal-title":"Med. Phys."},{"key":"pmbad40f5bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/j.1538-7305.1958.tb03874.x","type":"journal-article","article-title":"The measurement of power spectra from the point of view of communications engineering\u2014Part I","volume":"37","author":"Blackman","year":"1958","journal-title":"Bell Syst. Tech. J."},{"key":"pmbad40f5bib5","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1097\/RLI.0000000000000671","type":"journal-article","article-title":"X-ray dark-field radiography: potential for visualization of monosodium urate deposition","volume":"55","author":"Braig","year":"2019","journal-title":"Invest. Radiol."},{"key":"pmbad40f5bib6","doi-asserted-by":"publisher","first-page":"11578","DOI":"10.1364\/OE.480031","type":"journal-article","article-title":"Directional dark-field retrieval with single-grid x-ray imaging","volume":"31","author":"Croughan","year":"2023","journal-title":"Opt. Express"},{"key":"pmbad40f5bib7","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nnano.2007.217","type":"journal-article","article-title":"Targeted delivery of magnetic aerosol droplets to the lung","volume":"2","author":"Dames","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"pmbad40f5bib8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1364\/OE.474794","type":"journal-article","article-title":"High-speed processing of x-ray wavefront marking data with the unified modulated pattern analysis (UMPA) model","volume":"31","author":"De Marco","year":"2023","journal-title":"Opt. Express"},{"key":"pmbad40f5bib9","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.6984740","type":"software","author":"De Marco","year":"2022","unstructured":"De Marco F Thibault P Smith R Savatovic S 2022 Optimato\/umpa: Initial release of c++ version 10.5281\/zenodo.6984740"},{"key":"pmbad40f5bib10","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s42005-023-01412-9","type":"journal-article","article-title":"Femtosecond multimodal imaging with a laser-driven x-ray source","volume":"6","author":"Doherty","year":"2023","journal-title":"Commun. Phys."},{"key":"pmbad40f5bib11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.30802\/AALAS-JAALAS-23-000018","type":"journal-article","article-title":"Noncontact respiratory motion detection in anesthetized rodents","volume":"62","author":"Donnelley","year":"2023","journal-title":"J. Am. Assoc. Lab. Animal Sci."},{"key":"pmbad40f5bib12","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1107\/S160057751400856X","type":"journal-article","article-title":"Tracking extended mucociliary transport activity of individual deposited particles: longitudinal synchrotron x-ray imaging in live mice","volume":"21","author":"Donnelley","year":"2014","journal-title":"J. Synchrotron Radiat."},{"key":"pmbad40f5bib13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fphar.2018.01381","type":"journal-article","article-title":"Gene therapy for cystic fibrosis lung disease: overcoming the barriers to translation to the clinic","volume":"9","author":"Donnelley","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"pmbad40f5bib14","doi-asserted-by":"publisher","first-page":"9000","DOI":"10.1038\/s41598-022-12895-x","type":"journal-article","article-title":"Improved in vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging","volume":"12","author":"Donnelley","year":"2022","journal-title":"Sci. Rep."},{"key":"pmbad40f5bib15","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1364\/OL.381420","type":"journal-article","article-title":"Single-shot, omni-directional x-ray scattering imaging with a laboratory source and single-photon localization","volume":"45","author":"Dreier","year":"2020","journal-title":"Opt. Lett."},{"key":"pmbad40f5bib16","doi-asserted-by":"publisher","first-page":"8833","DOI":"10.1038\/s41598-020-65729-z","type":"journal-article","article-title":"Toward personalized synchrotron microbeam radiation therapy","volume":"10","author":"Engels","year":"2020","journal-title":"Sci. Rep."},{"key":"pmbad40f5bib17","doi-asserted-by":"publisher","first-page":"10983","DOI":"10.1038\/s41598-019-47465-1","type":"journal-article","article-title":"Particle coating alters mucociliary transit in excised rat trachea: a synchrotron X-ray imaging study","volume":"9","author":"Gardner","year":"2019","journal-title":"Sci. Rep."},{"key":"pmbad40f5bib18","doi-asserted-by":"publisher","first-page":"145012","DOI":"10.1088\/1361-6560\/ab7509","type":"journal-article","article-title":"Towards automated in vivo tracheal mucociliary transport measurement: detecting and tracking particle movement in synchrotron phase-contrast x-ray images","volume":"65","author":"Gardner","year":"2020","journal-title":"Phys. Med. Biol."},{"key":"pmbad40f5bib19","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1109\/TMI.2018.2868999","type":"journal-article","article-title":"Dynamic in vivo chest x-ray dark-field imaging in mice","volume":"38","author":"Gradl","year":"2019","journal-title":"IEEE Trans. Med. Imaging"},{"key":"pmbad40f5bib20","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1364\/OPTICA.441004","type":"journal-article","article-title":"High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators","volume":"8","author":"Gustschin","year":"2021","journal-title":"Optica"},{"key":"pmbad40f5bib21","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1021\/mp3001155","type":"journal-article","article-title":"Analysis of trajectories for targeting of magnetic nanoparticles in blood vessels","volume":"9","author":"Heidsieck","year":"2012","journal-title":"Mol. Pharmaceutics"},{"key":"pmbad40f5bib22","doi-asserted-by":"publisher","first-page":"10899","DOI":"10.1364\/OE.451834","type":"journal-article","article-title":"Quantifying the x-ray dark-field signal in single-grid imaging","volume":"30","author":"How","year":"2022","journal-title":"Opt. Express"},{"key":"pmbad40f5bib23","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1088\/0031-9155\/55\/12\/004","type":"journal-article","article-title":"Directional x-ray dark-field imaging","volume":"55","author":"Jensen","year":"2010","journal-title":"Phys. Med. Biol."},{"key":"pmbad40f5bib24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1103\/PhysRevLett.116.093902","type":"journal-article","article-title":"2D-Omnidirectional hard-x-ray scattering sensitivity in a single shot","volume":"116","author":"Kagias","year":"2016","journal-title":"Phys. Rev. Lett."},{"key":"pmbad40f5bib25","doi-asserted-by":"publisher","first-page":"23046","DOI":"10.1038\/s41598-021-02467-w","type":"journal-article","article-title":"Fast acquisition protocol for x-ray scattering tensor tomography","volume":"11","author":"Kim","year":"2021","journal-title":"Sci. Rep."},{"key":"pmbad40f5bib26","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1186\/s12967-021-03099-4","type":"journal-article","article-title":"Gene therapy for cystic fibrosis: new tools for precision medicine","volume":"19","author":"Lee","year":"2021","journal-title":"Journal of Translational Medicine"},{"key":"pmbad40f5bib27","doi-asserted-by":"publisher","first-page":"215503","DOI":"10.1103\/PhysRevLett.127.215503","type":"journal-article","article-title":"Dynamic multicontrast x-ray imaging method applied to additive manufacturing","volume":"127","author":"Massimi","year":"2021","journal-title":"Phys. Rev. Lett."},{"key":"pmbad40f5bib28","doi-asserted-by":"publisher","first-page":"12136","DOI":"10.1038\/s41598-022-15501-2","type":"journal-article","article-title":"Time resolved in situ multi-contrast x-ray imaging of melting in metals","volume":"12","author":"Massimi","year":"2022","journal-title":"Sci. Rep."},{"key":"pmbad40f5bib29","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1056\/NEJMoa1908639","type":"journal-article","article-title":"Elexacaftor-tezacaftor-ivacaftor for cystic fibrosis with a single Phe508del allele","volume":"381","author":"Middleton","year":"2019","journal-title":"New Engl. J. Med."},{"key":"pmbad40f5bib30","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.1364\/OL.38.004605","type":"journal-article","article-title":"A sensitive x-ray phase contrast technique for rapid imaging using a single phase grid analyzer","volume":"38","author":"Morgan","year":"2013","journal-title":"Opt. Lett."},{"key":"pmbad40f5bib31","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1107\/S1600577519014863","type":"journal-article","article-title":"Methods for dynamic synchrotron x-ray respiratory imaging in live animals Morgan Kaye Susannah","volume":"27","author":"Morgan","year":"2020","journal-title":"J. Synchrotron Radiat."},{"key":"pmbad40f5bib32","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nmat2096","type":"journal-article","article-title":"Hard-x-ray dark-field imaging using a grating interferometer","volume":"7","author":"Pfeiffer","year":"2008","journal-title":"Nat. Mater."},{"key":"pmbad40f5bib33","doi-asserted-by":"publisher","first-page":"p 21","DOI":"10.1117\/12.2594506","type":"conference-proceedings","article-title":"High-resolution quantitative phase-contrast x-ray imaging for biomedical samples at PETRA III","author":"Riedel","year":"2021"},{"key":"pmbad40f5bib34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mee.2012.08.025","type":"journal-article","article-title":"Fabrication of two-dimensional hard x-ray diffraction gratings","volume":"101","author":"Rutishauser","year":"2013","journal-title":"Microelectron. Eng."},{"key":"pmbad40f5bib35","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1364\/BOE.502664","type":"journal-article","article-title":"Multi-resolution x-ray phase-contrast and dark-field tomography of human cerebellum with near-field speckles","volume":"15","author":"Savatovi\u0107","year":"2024","journal-title":"Biomed. Opt. Express"},{"key":"pmbad40f5bib36","doi-asserted-by":"publisher","first-page":"17880","DOI":"10.1073\/pnas.1206684109","type":"journal-article","article-title":"Emphysema diagnosis using x-ray dark-field imaging at a laser-driven compact synchrotron light source","volume":"109","author":"Schleede","year":"2012","journal-title":"PNAS"},{"key":"pmbad40f5bib37","doi-asserted-by":"publisher","author":"Smith","unstructured":"Smith R 2022 optimato\/UMPA_directional_dark_field: Initial Release 10.5281\/zenodo.6981376","DOI":"10.5281\/zenodo.6981376","type":"software"},{"key":"pmbad40f5bib38","doi-asserted-by":"publisher","DOI":"10.1063\/5.0168156","type":"conference-proceedings","article-title":"Speckle-based directional dark-field x-ray imaging with a liquid-metal-jet source","author":"Smith","year":"2023"},{"key":"pmbad40f5bib39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0273315","type":"journal-article","article-title":"X-ray directional dark-field imaging using unified modulated pattern analysis","volume":"17","author":"Smith","year":"2022","journal-title":"PLoS One"},{"key":"pmbad40f5bib40","article-title":"Directional Dark-Field X-ray Imaging of Composite Materials","author":"Smith","year":"2023","type":"other"},{"key":"pmbad40f5bib41","doi-asserted-by":"publisher","DOI":"10.25909\/24085896.v1","type":"dataset","article-title":"Directional Dark-Field Imaging Data of Magnet Assisted Airway Treatment Delivery","author":"Smith","year":"2024","unstructured":"Smith R McCarron A Morgan K Reyne N Cmielewski P Parsons D Donnelley M 2024 Directional Dark-Field Imaging Data of Magnet Assisted Airway Treatment Delivery University of Adelaide Repository 10.25909\/24085896.v1"},{"key":"pmbad40f5bib42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/magnetochemistry6020025","type":"journal-article","article-title":"Successes and challenges: inhaled treatment approaches using magnetic nanoparticles in cystic fibrosis","volume":"6","author":"Tan","year":"2020","journal-title":"Magnetochemistry"},{"key":"pmbad40f5bib43","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2147\/AGG.S53768","type":"journal-article","article-title":"Cystic fibrosis gene mutations: evaluation and assessment of disease severity","volume":"161","author":"Vallieres","year":"2014","journal-title":"Adv. Genomics Genetics"},{"key":"pmbad40f5bib44","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1073\/pnas.2118799119","type":"journal-article","article-title":"Dark-field computed tomography reaches the human scale","volume":"119","author":"Viermetz","year":"2022","journal-title":"PNAS"},{"key":"pmbad40f5bib45","doi-asserted-by":"publisher","DOI":"10.1063\/1.4922189","type":"journal-article","article-title":"Beam tracking approach for single-shot retrieval of absorption, refraction, and dark-field signals with laboratory x-ray sources","author":"Vittoria","year":"2015","journal-title":"Appl. Phys. Lett."},{"key":"pmbad40f5bib46","doi-asserted-by":"publisher","first-page":"e733","DOI":"10.1016\/S2589-7500(21)00146-1","type":"journal-article","article-title":"X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study","volume":"3","author":"Willer","year":"2021","journal-title":"Lancet. Digit. Health"},{"key":"pmbad40f5bib47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1103\/PhysRevLett.112.253903","type":"journal-article","article-title":"Speckle-based x-ray phase-contrast and dark-field imaging with a laboratory source","volume":"112","author":"Zanette","year":"2014","journal-title":"Phys. Rev. Lett."},{"key":"pmbad40f5bib48","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.118.203903","type":"journal-article","article-title":"X-ray phase-contrast imaging and metrology through unified modulated pattern analysis","volume":"118","author":"Zdora","year":"2017","journal-title":"Phys. Rev. Lett."},{"key":"pmbad40f5bib49","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1364\/AO.384531","type":"journal-article","article-title":"X-ray phase imaging with the unified modulated pattern analysis of near-field speckles at a laboratory source","volume":"59","author":"Zdora","year":"2020","journal-title":"Appl. Opt."},{"key":"pmbad40f5bib50","doi-asserted-by":"publisher","DOI":"10.1063\/1.5047400","type":"journal-article","article-title":"Single-shot x-ray dark-field imaging with omnidirectional sensitivity using random-pattern wavefront modulator","volume":"113","author":"Zhou","year":"2018","journal-title":"Appl. Phys. Lett."}],"container-title":["Physics in Medicine &amp; Biology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:35:56Z","timestamp":1778776556000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad40f5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5,9]]},"published-print":{"date-parts":[[2024,5,21]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/ad40f5","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"assertion":[{"value":"Ultra-fast\n                      in vivo\n                      directional dark-field x-ray imaging for visualising magnetic control of particles for airway gene delivery","name":"article_title","label":"Article Title"},{"value":"Physics in Medicine & Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2024 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2024-02-09","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-04-19","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-05-09","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}