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To enhance the investigations on MC calculated beam quality correction factors of thimble ionization chambers from high-energy brachytherapy sources and to develop reliable reference conditions in source and detector setups in water. <jats:italic>Approach<\/jats:italic>. The response of five different ionization chambers from PTW-Freiburg and Standard Imaging was investigated for irradiation by a high dose rate Ir-192 Flexisource in water. For a setup in a Beamscan water phantom, Monte Carlo simulations were performed to calculate correction factors for the chamber readings. After exact positioning of source and detector the absorbed dose rate at the TG-43 reference point at one centimeter nominal distance from the source was measured using these factors and compared to the specification of the calibration certificate. The Monte Carlo calculations were performed using the restricted cema formalism to gain further insight into the chamber response. Calculations were performed for the sensitive volume of the chambers, determined by the methods currently used in investigations of dosimetry in magnetic fields. <jats:italic>Main results<\/jats:italic>. Measured dose rates and values from the calibration certificate agreed within the combined uncertainty (<jats:italic>k<\/jats:italic> = 2) for all chambers except for one case in which the full air cavity was simulated. The chambers showed a distinct directional dependence. With the restricted cema formalism calculations it was possible to examine volume averaging and energy dependence of the perturbation factors contributing to the beam quality correction factor also differential in energy. <jats:italic>Significance<\/jats:italic>. This work determined beam quality correction factors to measure the absorbed dose rate from a brachytherapy source in terms of absorbed dose to water for a variety of ionization chambers. For the accurate dosimetry of brachytherapy sources with ionization chambers it is advisable to use correction factors based on the sensitive volume of the chambers and to take account for the directional dependence of chamber response.<\/jats:p>","DOI":"10.1088\/1361-6560\/ad638b","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T23:01:07Z","timestamp":1721084467000},"page":"165002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigations on the beam quality correction factor for ionization chambers in high-energy brachytherapy dosimetry"],"prefix":"10.1088","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-7769","authenticated-orcid":true,"given":"T","family":"Failing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F W","family":"Hensley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-8330","authenticated-orcid":false,"given":"B","family":"Keil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5785-4101","authenticated-orcid":true,"given":"K","family":"Zink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"pmbad638bbib1","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1118\/1.598691","article-title":"AAPM\u2019s TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams","volume":"26","author":"Almond","year":"1999","journal-title":"Med. 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