{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:30:07Z","timestamp":1794274207635,"version":"4.9.0"},"reference-count":34,"publisher":"IOP Publishing","issue":"17","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2024,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Purpose.<\/jats:italic>\n                    To assess how inter-subject variations in brain vasculature among glioblastoma (GBM) patients affects the calculated dose received by circulating blood cells (CBC) during radiotherapy and its subsequent impact on CBC depletion.\n                    <jats:italic>Methods.<\/jats:italic>\n                    Ten GBM patients treated with either intensity-modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT) were selected. For each patient, 23 cerebrovascular models were developed based on 23 healthy subject MR-angiography data to simulate intra- and inter-subject blood vessel diversity. Based on the corresponding treatment plan of the patient, the dose to CBC was calculated for all the 230 scenarios. The impact of inter-subject variation on fraction of irradiated blood volume (\n                    <jats:italic>\n                      V\n                      <jats:sub>D<\/jats:sub>\n                    <\/jats:italic>\n                    <jats:sub>&gt;0 cGy<\/jats:sub>\n                    ) and lymphocyte kill rates as a function of the clinical target volume (CTV) size and treatment technique were analyzed.\n                    <jats:italic>Results.<\/jats:italic>\n                    The dose fluctuation to CBC was higher in IMRT plans compared to VMAT plans. The uncertainty in the\n                    <jats:italic>\n                      V\n                      <jats:sub>D<\/jats:sub>\n                    <\/jats:italic>\n                    <jats:sub>&gt;0 cGy<\/jats:sub>\n                    was 18.3% for IMRT and 2.0% (CI\n                    <jats:sub>95%<\/jats:sub>\n                    ) for VMAT and the dispersion of the\n                    <jats:italic>D<\/jats:italic>\n                    <jats:sub>2%<\/jats:sub>\n                    index was 6 cGy for IMRT and 1 cGy for VMAT (CI\n                    <jats:sub>95%<\/jats:sub>\n                    ) for one single treatment fraction of 200 cGy. The uncertainty in killed CBC due to inter-subject diversity in brain blood vessel increased with increasing CTV size and was\n                    <jats:italic>\u03c3<\/jats:italic>\n                    = 11.2%.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . VMAT showed greater robustness against inter-subject variation in blood vessels compared to IMRT. We recommend considering the uncertainty in depleting CBC resulting from the use of less patient-specific and generic blood vessel phantoms to improve the radiation-induced lymphopenia assessments.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/ad69f9","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T19:54:30Z","timestamp":1722455670000},"page":"175010","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Inter-subject cerebrovascular variability: a source of uncertainty for dose calculation to circulating blood cells for glioblastoma patients treated with modern radiotherapy techniques"],"prefix":"10.1088","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-1180","authenticated-orcid":true,"given":"Abdelkhalek","family":"Hammi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-2551","authenticated-orcid":true,"given":"Nadya","family":"Shusharina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Djuffouo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"pmbad69f9bib1","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1098\/rstb.2001.0905","article-title":"Generation, description and storage of dendritic morphology data","volume":"356","author":"Ascoli","year":"2001","journal-title":"Phil. 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