{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:50:32Z","timestamp":1788778232710,"version":"build-2803163510"},"reference-count":63,"publisher":"IOP Publishing","issue":"23","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"crossref","award":["17921"],"award-info":[{"award-number":["17921"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016036","name":"Top Sector Life Sciences & Health","doi-asserted-by":"crossref","award":["17921"],"award-info":[{"award-number":["17921"]}],"id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"crossref","award":["17921"],"award-info":[{"award-number":["17921"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2024,12,7]]},"abstract":"Abstract<\/jats:title>\n \n Purpose.<\/jats:italic> Patient-tailored intracavitary\/interstitial (IC\/IS) brachytherapy (BT) applicators may increase dose conformity in cervical cancer patients. Current configuration planning methods in these custom applicators rely on manual specification or a small set of (straight) needles. This work introduces and validates a two-stage approach for establishing channel configurations in the 3D printed patient-tailored ARCHITECT applicator. Methods.<\/jats:italic> For each patient, the patient-tailored applicator shape was based on the first BT application with a commercial applicator and integrated connectors to a commercial (Geneva) intrauterine tube and two lunar ring channels. First, a large candidate set was generated of channels that steer the needle to desired poses in the target region and are contained in the applicator. The channels\u2019 centrelines were represented by B\u00e9zier curves. Channels running between straight target segments and entry points were optimised and refined to ensure (dynamic) feasibility. Second, channel configurations were selected using geometric coverage optimisation. This workflow was applied to establish patient-tailored geometries for twenty-two patients previously treated using the Venezia applicator. Treatment plans were automatically generated using the in-house developed algorithm BiCycle. Plans for the clinically used configuration, \n \n \n \n \n T<\/mml:mtext>\n <\/mml:mrow>\n \n \n \n P<\/mml:mtext>\n <\/mml:mrow>\n \n \n clin<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>, and patient-tailored configuration, \n \n \n \n \n T<\/mml:mtext>\n <\/mml:mrow>\n \n \n \n P<\/mml:mtext>\n <\/mml:mrow>\n \n \n arch<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>, were compared. Results.<\/jats:italic> Channel configurations could be generated in clinically feasible time (median: 2651 s, range 1826\u20133812 s). All \n \n \n \n \n T<\/mml:mtext>\n <\/mml:mrow>\n \n \n \n P<\/mml:mtext>\n <\/mml:mrow>\n \n \n arch<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> and \n \n \n \n \n T<\/mml:mtext>\n <\/mml:mrow>\n \n \n \n P<\/mml:mtext>\n <\/mml:mrow>\n \n \n clin<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> plans were acceptable, but planning aims were more frequently attained with patient-tailored configurations (115\/132 versus 100\/132 instances). Median CTVIR<\/jats:sub>\n \n \n \n \n \n \n D<\/mml:mi>\n \n 98<\/mml:mn>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> and bladder \n \n \n \n \n \n D<\/mml:mi>\n \n 2<\/mml:mn>\n \n c<\/mml:mtext>\n <\/mml:mrow>\n \n \n \n m<\/mml:mtext>\n <\/mml:mrow>\n 3<\/mml:mn>\n <\/mml:msup>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> doses significantly improved (\n \n \n \n p<\/mml:mi>\n \n <<\/mml:mo>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> 0.001 and \n \n \n \n p<\/mml:mi>\n \n <<\/mml:mo>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> 0.01 respectively) in \n \n \n \n \n T<\/mml:mtext>\n <\/mml:mrow>\n \n \n \n P<\/mml:mtext>\n <\/mml:mrow>\n \n \n arch<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> plans in comparison with \n \n \n \n \n T<\/mml:mtext>\n <\/mml:mrow>\n \n \n \n P<\/mml:mtext>\n <\/mml:mrow>\n \n \n clin<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> plans, and in approximately half of the patients dosimetric indices improved. Conclusion.<\/jats:italic> Automated patient-tailored BT channel configuration planning for 3D printed applicators is clinically feasible. A treatment planning study showed that all plans met planning limits for the patient-tailored configurations, and in selected cases improved the plan quality in comparison with commercial applicator configurations.<\/jats:p>","DOI":"10.1088\/1361-6560\/ad8b08","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T22:55:30Z","timestamp":1729810530000},"page":"235007","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Automated planning of curved needle channels in 3D printed patient-tailored applicators for cervical cancer brachytherapy"],"prefix":"10.1088","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-8880","authenticated-orcid":true,"given":"Robin","family":"Straathof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1189-2089","authenticated-orcid":false,"given":"Sharline M","family":"van Vliet-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8452-3198","authenticated-orcid":false,"given":"Inger-Karine K","family":"Kolkman-Deurloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6125-9812","authenticated-orcid":false,"given":"Linda S G L","family":"Wauben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-2982","authenticated-orcid":false,"given":"Remi A","family":"Nout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-0528","authenticated-orcid":true,"given":"Ben J M","family":"Heijmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-2504","authenticated-orcid":true,"given":"Linda","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-2129","authenticated-orcid":false,"given":"Jenny","family":"Dankelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-990X","authenticated-orcid":true,"given":"Nick J","family":"van de Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"pmbad8b08bib1","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1118\/1.4908000","article-title":"Automatic learning-based beam angle selection for thoracic IMRT","volume":"42","author":"Amit","year":"2015","journal-title":"Med. Phys."},{"key":"pmbad8b08bib2","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s00371-010-0416-3","article-title":"A lightweight approach to repairing digitized polygon meshes","volume":"26","author":"Attene","year":"2010","journal-title":"Vis. Comput."},{"key":"pmbad8b08bib3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.5114\/jcb.2016.57535","article-title":"Concomitant cervical and transperineal parametrial high-dose-rate brachytherapy boost for locally advanced cervical cancer","volume":"8","author":"Bailleux","year":"2016","journal-title":"J. Contemp. Brachytherapy"},{"key":"pmbad8b08bib4","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S0360-3016(97)00732-3","article-title":"A conformal index (COIN) to evaluate implant quality and dose specification in brachytherapy","volume":"40","author":"Baltas","year":"1998","journal-title":"Int. J. Radiat Oncol. Biol. Phys."},{"key":"pmbad8b08bib5","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1002\/mp.16874","article-title":"Simultaneous catheter and multicriteria optimization for HDR cervical cancer brachytherapy with a complex intracavity\/interstitial applicator","volume":"51","author":"B\u00e9langer","year":"2024","journal-title":"Med. Phys."},{"key":"pmbad8b08bib6","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.brachy.2020.06.016","article-title":"Evaluating the impact of real-time multicriteria optimizers integrated with interactive plan navigation tools for HDR brachytherapy","volume":"19","author":"B\u00e9langer","year":"2020","journal-title":"Brachytherapy"},{"key":"pmbad8b08bib7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cag.2011.03.025","article-title":"Computation of the minimum distance between two B\u00e9zier curves\/surfaces","volume":"35","author":"Chang","year":"2011","journal-title":"Comput. Graph."},{"key":"pmbad8b08bib8","doi-asserted-by":"publisher","first-page":"6575","DOI":"10.1002\/mp.15878","article-title":"Catheters and dose optimization using a modified CVT algorithm and multi-criteria optimization in prostate HDR brachytherapy","volume":"49","author":"Chatigny","year":"2022","journal-title":"Med. Phys."},{"key":"pmbad8b08bib9","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1080\/0284186X.2023.2246642","article-title":"Clinical outcomes using a 3D printed tandem-needle-template and the EMBRACE-II planning aims for image guided adaptive brachytherapy in locally advanced cervical cancer","volume":"62","author":"Cobussen","year":"2023","journal-title":"Acta Oncol."},{"key":"pmbad8b08bib10","doi-asserted-by":"publisher","first-page":"5889","DOI":"10.1109\/ICRA.2014.6907726","article-title":"Planning locally optimal, curvature-constrained trajectories in 3D using sequential convex optimization","author":"Duan","year":"2014"},{"key":"pmbad8b08bib11","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1109\/LRA.2019.2926221","article-title":"Planning for flexible surgical robots via B\u00e9zier spline translation","volume":"4","author":"Fauser","year":"2019","journal-title":"IEEE Robot. Autom. Lett."},{"key":"pmbad8b08bib12","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.radonc.2016.03.020","article-title":"Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: analysis from the retroEMBRACE study","volume":"120","author":"Fokdal","year":"2016","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib13","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.radonc.2018.05.002","article-title":"Physician assessed and patient reported urinary morbidity after radio-chemotherapy and image guided adaptive brachytherapy for locally advanced cervical cancer","volume":"127","author":"Fokdal","year":"2018","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.radonc.2013.01.010","article-title":"Clinical feasibility of combined intracavitary\/interstitial brachytherapy in locally advanced cervical cancer employing MRI with a tandem\/ring applicator in situ and virtual preplanning of the interstitial component","volume":"107","author":"Fokdal","year":"2013","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib15","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1016\/j.brachy.2016.04.010","article-title":"Image guided brachytherapy in cervical cancer: a comparison between intracavitary and combined intracavitary\/interstitial brachytherapy in regard to doses to HR CTV, OARs and late morbidity\u2014early results from the EMBRACE study in 999 patients","volume":"15","author":"Fortin","year":"2016","journal-title":"Brachytherapy"},{"key":"pmbad8b08bib16","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1109\/ICRA.2018.8462878","article-title":"Online safe trajectory generation for quadrotors using fast marching method and Bernstein basis polynomial","author":"Gao","year":"2018"},{"key":"pmbad8b08bib17","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1109\/CoASE.2013.6654002","article-title":"An algorithm for computing customized 3D printed implants with curvature constrained channels for enhancing intracavitary brachytherapy radiation delivery","author":"Garg","year":"2013"},{"key":"pmbad8b08bib18","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/mp.16804","article-title":"Robust stochastic optimization of needle configurations for robotic HDR prostate brachytherapy","volume":"51","author":"Gerlach","year":"2024","journal-title":"Med. Phys."},{"key":"pmbad8b08bib19","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1088\/0031-9155\/58\/4\/1041","article-title":"Mixed integer programming improves comprehensibility and plan quality in inverse optimization of prostate HDR brachytherapy","volume":"58","author":"Gorissen","year":"2013","journal-title":"Phys. Med. Biol."},{"key":"pmbad8b08bib20","doi-asserted-by":"publisher","first-page":"5956","DOI":"10.1088\/0031-9155\/61\/16\/5956","article-title":"Real-time inverse high-dose-rate brachytherapy planning with catheter optimization by compressed sensing-inspired optimization strategies","volume":"61","author":"Guthier","year":"2016","journal-title":"Phys. Med. Biol."},{"key":"pmbad8b08bib21","doi-asserted-by":"publisher","first-page":"6117","DOI":"10.1002\/mp.12590","article-title":"A fast inverse treatment planning strategy facilitating optimized catheter selection in image-guided high-dose-rate interstitial gynecologic brachytherapy","volume":"44","author":"Guthier","year":"2017","journal-title":"Med. Phys."},{"key":"pmbad8b08bib22","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s10479-013-1448-7","article-title":"Heuristics for integrated optimization of catheter positioning and dwell time distribution in prostate HDR brachytherapy","volume":"236","author":"Holm","year":"2016","journal-title":"Ann. Oper. Res."},{"key":"pmbad8b08bib23","article-title":"gptoolbox: geometry processing toolbox","author":"Jacobson","year":"2023"},{"key":"pmbad8b08bib24","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.3390\/app11062592","article-title":"Feasibility study of robust optimization to reduce dose delivery uncertainty by potential applicator displacements for a cervix brachytherapy","volume":"11","author":"Jo","year":"2021","journal-title":"Appl. Sci."},{"key":"pmbad8b08bib25","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/978-3-642-03474-9_172","article-title":"Optimization of catheter position and dwell time in prostate HDR brachytherapy using HIPO and linear programming","author":"Karabis","year":"2009"},{"key":"pmbad8b08bib26","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.ijrobp.2015.12.363","article-title":"Health-related quality of life in locally advanced cervical cancer patients after definitive chemoradiation therapy including image guided adaptive brachytherapy: an analysis from the EMBRACE study","volume":"94","author":"Kirchheiner","year":"2016","journal-title":"Int. J. Radiat Oncol. Biol. Phys."},{"key":"pmbad8b08bib27","doi-asserted-by":"publisher","DOI":"10.1101\/2021.06.11.21258244","article-title":"A row-generation approach for simultaneous multiple needle trajectory planning in radiofrequency ablation","author":"Kulkarni-Thaker","year":"2021"},{"key":"pmbad8b08bib28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41205-019-0047-x","article-title":"MRI-driven design of customised 3D printed gynaecological brachytherapy applicators with curved needle channels","volume":"5","author":"Laan","year":"2019","journal-title":"3D Print. Med."},{"key":"pmbad8b08bib29","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/itor.12093","article-title":"A fast beam orientation optimization method that enforces geometric constraints in IMRT for total marrow irradiation","volume":"22","author":"Lee","year":"2014","journal-title":"Int. Trans. Oper. Res."},{"key":"pmbad8b08bib30","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1088\/0031-9155\/56\/17\/014","article-title":"A set cover approach to fast beam orientation optimization in intensity modulated radiation therapy for total marrow irradiation","volume":"56","author":"Lee","year":"2011","journal-title":"Phys. Med. Biol."},{"key":"pmbad8b08bib31","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.radonc.2015.12.012","article-title":"Individualised 3D printed vaginal template for MRI guided brachytherapy in locally advanced cervical cancer","volume":"118","author":"Lindegaard","year":"2016","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib32","doi-asserted-by":"publisher","first-page":"128","DOI":"10.5114\/jcb.2019.84741","article-title":"Development and assessment of 3D-printed individual applicators in gynecological MRI-guided brachytherapy","volume":"11","author":"Logar","year":"2019","journal-title":"J. Contemp. Brachytherapy"},{"key":"pmbad8b08bib33","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.brachy.2009.08.014","article-title":"Technical aspects and perspectives of the vaginal mold applicator for brachytherapy of gynecologic malignancies","volume":"9","author":"Magn\u00e9","year":"2010","journal-title":"Brachytherapy"},{"key":"pmbad8b08bib34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.radonc.2019.08.004","article-title":"Vienna-II ring applicator for distal parametrial\/pelvic wall disease in cervical cancer brachytherapy: an experience from two institutions: clinical feasibility and outcome","volume":"141","author":"Mahantshetty","year":"2019","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2514\/6.2015-0598","article-title":"Collision avoidance through path replanning using B\u00e9zier curves","author":"Mehdi","year":"2015"},{"key":"pmbad8b08bib36","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1109\/ICRA.2011.5980409","article-title":"Minimum snap trajectory generation and control for quadrotors","author":"Mellinger","year":"2011"},{"key":"pmbad8b08bib37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21105\/joss.00506","article-title":"GIBBON: the geometry and image-based bioengineering add-On","volume":"3","author":"Moerman","year":"2018","journal-title":"J. Open Source Softw."},{"key":"pmbad8b08bib38","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1002\/mp.14762","article-title":"Optimization in treatment planning of high dose-rate brachytherapy\u2014review and analysis of mathematical models","volume":"48","author":"Mor\u00e9n","year":"2021","journal-title":"Med. Phys."},{"key":"pmbad8b08bib39","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.brachy.2014.10.004","article-title":"A unique approach to high-dose-rate vaginal mold brachytherapy of gynecologic malignancies","volume":"14","author":"Nilsson","year":"2015","journal-title":"Brachytherapy"},{"key":"pmbad8b08bib40","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.radonc.2020.04.017","article-title":"Fast and fully-automated multi-criterial treatment planning for adaptive HDR brachytherapy for locally advanced cervical cancer","volume":"148","author":"Oud","year":"2020","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib41","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1109\/TASE.2015.2475121","article-title":"Planning curvature and torsion constrained ribbons in 3D with application to intracavitary brachytherapy","volume":"12","author":"Patil","year":"2015","journal-title":"IEEE Trans. Autom. Sci. Eng."},{"key":"pmbad8b08bib42","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1515\/raon-2016-0048","article-title":"Virtual modelling of novel applicator prototypes for cervical cancer brachytherapy","volume":"50","author":"Petric","year":"2016","journal-title":"Radiol. Oncol."},{"key":"pmbad8b08bib43","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.radonc.2007.04.012","article-title":"Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer","volume":"83","author":"P\u00f6tter","year":"2007","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib44","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ctro.2018.01.001","article-title":"The EMBRACE II study: the outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies","volume":"9","author":"P\u00f6tter","year":"2018","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"pmbad8b08bib45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1118\/1.4826335","article-title":"Adaptation of the CVT algorithm for catheter optimization in high dose rate brachytherapy","volume":"40","author":"Poulin","year":"2013","journal-title":"Med. Phys."},{"key":"pmbad8b08bib46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1115\/1.4049395","article-title":"Deformation modeling of a flexible instrument using a B\u00e9zier curve","volume":"15","author":"Rajesh","year":"2021","journal-title":"J. Med. Devices"},{"key":"pmbad8b08bib47","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.radonc.2022.02.022","article-title":"Multi-center analysis of machine-learning predicted dose parameters in brachytherapy for cervical cancer","volume":"170","author":"Reijtenbagh","year":"2022","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib48","first-page":"649","article-title":"Polynomial trajectory planning for aggressive quadrotor flight in dense indoor environments","author":"Richter","year":"2016"},{"key":"pmbad8b08bib49","doi-asserted-by":"publisher","first-page":"S215","DOI":"10.1016\/S0167-8140(24)00985-X","article-title":"Clinician Preferred, Fast Autoplanning in Cervical Cancer Brachytherapy Using BiCycle","volume":"194","author":"Rossi","year":"2024","journal-title":"Radiat. Oncol. J."},{"key":"pmbad8b08bib50","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1145\/3071178.3071311","article-title":"Exploring trade-offs between target coverage, healthy tissue sparing, and the placement of catheters in HDR brachytherapy for prostate cancer using a novel multi-objective model-based mixed-integer evolutionary algorithm","author":"Sadowski","year":"2017"},{"key":"pmbad8b08bib51","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.ijrobp.2019.12.019","article-title":"Ring versus ovoids and intracavitary versus intracavitary-interstitial applicators in cervical cancer brachytherapy: results from the EMBRACE I study","volume":"106","author":"Serban","year":"2020","journal-title":"Int. J. Radiat Oncol. Biol. Phys."},{"key":"pmbad8b08bib52","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.brachy.2021.03.019","article-title":"Characterization of combined intracavitary\/interstitial brachytherapy including oblique needles in locally advanced cervix cancer","volume":"20","author":"Serban","year":"2021","journal-title":"Brachytherapy"},{"key":"pmbad8b08bib53","doi-asserted-by":"publisher","first-page":"4339","DOI":"10.1118\/1.4728226","article-title":"NPIP: a skew line needle configuration optimization system for HDR brachytherapy","volume":"39","author":"Siauw","year":"2012","journal-title":"Med. Phys."},{"key":"pmbad8b08bib54","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1002\/mp.16934","article-title":"Multibody dynamic modeling of the behavior of flexible instruments used in cervical cancer brachytherapy","volume":"51","author":"Straathof","year":"2024","journal-title":"Med. Phys."},{"key":"pmbad8b08bib55","doi-asserted-by":"publisher","DOI":"10.1117\/12.2081436","article-title":"Reconstruction of surfaces from planar contours through contour interpolation","volume":"9415","author":"Sunderland","year":"2015"},{"key":"pmbad8b08bib56","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.radonc.2008.06.010","article-title":"Consequences of random and systematic reconstruction uncertainties in 3D image based brachytherapy in cervical cancer","volume":"89","author":"Tanderup","year":"2008","journal-title":"Radiother. Oncol."},{"key":"pmbad8b08bib57","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1145\/3205455.3205505","article-title":"Better and faster catheter position optimization in HDR brachytherapy for prostate cancer using multi-objective real-valued GOMEA","author":"van der Meer","year":"2018"},{"key":"pmbad8b08bib58","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1467-8659.1995.cgf143_0097.x","article-title":"Modeling 3D curves of minimal energy","volume":"14","author":"Veltkamp","year":"1995","journal-title":"Comput. Graph. Forum"},{"key":"pmbad8b08bib59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1088\/1361-6560\/abd00e","article-title":"Simultaneous needle catheter selection and dwell time optimization for preplanning of high-dose-rate brachytherapy of prostate cancer","volume":"66","author":"Wang","year":"2021","journal-title":"Phys. Med. Biol."},{"key":"pmbad8b08bib60","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.brachy.2014.12.006","article-title":"Customized vaginal vault brachytherapy with computed tomography imaging-derived applicator prototyping","volume":"14","author":"Wiebe","year":"2015","journal-title":"Brachytherapy"},{"key":"pmbad8b08bib61","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.brachy.2020.04.008","article-title":"A knowledge-based organ dose prediction tool for brachytherapy treatment planning of patients with cervical cancer","volume":"19","author":"Yusufaly","year":"2020","journal-title":"Brachytherapy"},{"key":"pmbad8b08bib62","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.4103\/jcrt.JCRT_292_19","article-title":"Individualized and inverse optimized needle configuration for combined intracavitary-interstitial brachytherapy in locally advanced cervical cancer","volume":"15","author":"Zhang","year":"2019","journal-title":"J. Cancer Res. Ther."},{"key":"pmbad8b08bib63","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1109\/TASE.2018.2864773","article-title":"Energy-optimal collision-free motion planning for multiaxis motion systems: an alternating quadratic programming approach","volume":"16","author":"Zhao","year":"2019","journal-title":"IEEE Trans. Autom. Sci. Eng."}],"container-title":["Physics in Medicine & Biology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T08:57:40Z","timestamp":1732525060000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ad8b08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":63,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,11,25]]},"published-print":{"date-parts":[[2024,12,7]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/ad8b08","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"Automated planning of curved needle channels in 3D printed patient-tailored applicators for cervical cancer brachytherapy","name":"article_title","label":"Article Title"},{"value":"Physics in Medicine & Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2024 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2024-04-17","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-10-24","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-11-25","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}